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Contractile properties of ureters from rats with infravesical urinary outlet obstruction

Hjortswang, Henrik; Malmqvist, Ulf LU ; Uvelius, Bengt LU and Arner, Anders (1998) In Urological Research 26(5). p.337-342
Abstract
Mechanical properties of ureters from rats with infravesical urinary outflow obstruction were studied in vitro. Urinary outflow obstruction was created by partial ligation of the urethra in female rats. After 10 days a marked hypertrophy of the urinary bladder and a dilatation of the ureters were observed. Proximal and distal segments of the ureters from these animals were isolated and mounted in a wire myograph for force registration. Comparisons were made with ureters from control rats. The ureters from the rats with urinary outflow obstruction exhibited a large increase in lumen diameter and an unchanged thickness of the muscle layer. These data suggest that the dilatation of the ureters is associated with growth of the smooth muscle in... (More)
Mechanical properties of ureters from rats with infravesical urinary outflow obstruction were studied in vitro. Urinary outflow obstruction was created by partial ligation of the urethra in female rats. After 10 days a marked hypertrophy of the urinary bladder and a dilatation of the ureters were observed. Proximal and distal segments of the ureters from these animals were isolated and mounted in a wire myograph for force registration. Comparisons were made with ureters from control rats. The ureters from the rats with urinary outflow obstruction exhibited a large increase in lumen diameter and an unchanged thickness of the muscle layer. These data suggest that the dilatation of the ureters is associated with growth of the smooth muscle in the wall. All ureter preparations were relaxed in normal physiological salt solution. When the extracellular K+ concentration was increased to 20 mM the dilated ureters became spontaneously active. At [K+] in the range 20-40 mM in the presence of noradrenaline (10(-5) M) all ureters exhibited high-frequency spontaneous contractions. The dilated ureters had a lower frequency of spontaneous contractions and a higher force. The results show a pronounced remodelling of the ureter wall following infravesical outlet obstruction. The structural changes were associated with alterations in the contraction pattern of the preparations, most probably reflecting changes in the excitation-contraction coupling of the growing cells. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ureter, Urinary bladder, Smooth muscle, Hypertrophy, Rats
in
Urological Research
volume
26
issue
5
pages
337 - 342
publisher
Springer
external identifiers
  • pmid:9840343
  • scopus:0031770254
ISSN
0300-5623
DOI
10.1007/s002400050066
language
English
LU publication?
yes
id
51632ac8-5253-491c-92e6-ca01140463ba (old id 1113743)
date added to LUP
2008-07-16 10:47:16
date last changed
2017-02-22 11:44:10
@article{51632ac8-5253-491c-92e6-ca01140463ba,
  abstract     = {Mechanical properties of ureters from rats with infravesical urinary outflow obstruction were studied in vitro. Urinary outflow obstruction was created by partial ligation of the urethra in female rats. After 10 days a marked hypertrophy of the urinary bladder and a dilatation of the ureters were observed. Proximal and distal segments of the ureters from these animals were isolated and mounted in a wire myograph for force registration. Comparisons were made with ureters from control rats. The ureters from the rats with urinary outflow obstruction exhibited a large increase in lumen diameter and an unchanged thickness of the muscle layer. These data suggest that the dilatation of the ureters is associated with growth of the smooth muscle in the wall. All ureter preparations were relaxed in normal physiological salt solution. When the extracellular K+ concentration was increased to 20 mM the dilated ureters became spontaneously active. At [K+] in the range 20-40 mM in the presence of noradrenaline (10(-5) M) all ureters exhibited high-frequency spontaneous contractions. The dilated ureters had a lower frequency of spontaneous contractions and a higher force. The results show a pronounced remodelling of the ureter wall following infravesical outlet obstruction. The structural changes were associated with alterations in the contraction pattern of the preparations, most probably reflecting changes in the excitation-contraction coupling of the growing cells.},
  author       = {Hjortswang, Henrik and Malmqvist, Ulf and Uvelius, Bengt and Arner, Anders},
  issn         = {0300-5623},
  keyword      = {Ureter,Urinary bladder,Smooth muscle,Hypertrophy,Rats},
  language     = {eng},
  number       = {5},
  pages        = {337--342},
  publisher    = {Springer},
  series       = {Urological Research},
  title        = {Contractile properties of ureters from rats with infravesical urinary outlet obstruction},
  url          = {http://dx.doi.org/10.1007/s002400050066},
  volume       = {26},
  year         = {1998},
}