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Humoral immune response to conserved epitopes of Chlamydia trachomatis and human 60-kDa heat-shock protein in women with pelvic inflammatory disease

Domeika, M; Domeika, K; Paavonen, J; Mårdh, Per-Anders LU and Witkin, S S (1998) In Journal of Infectious Diseases 177(3). p.714-719
Abstract
The association between humoral immunity to unique and conserved epitopes of the Chlamydia trachomatis 60-kDa heat-shock protein (hsp60) and immunity to human hsp60 was examined in 129 women with laparoscopically verified pelvic inflammatory disease. An ELISA was used to detect antichlamydial IgG and IgA antibodies, IgG antibodies to recombinant human hsp60, and antibodies to two synthetic peptides of chlamydial hsp60. Half of the patients had antibodies to human hsp60, which correlated with the presence of antibodies to the chlamydial hsp60 peptide 260-271 homologous to the human hsp60 (P = .01). Antibodies to peptide 260-271 were associated with antichlamydial IgG (P < .0001) and IgA (P < .0001). The results suggest that the... (More)
The association between humoral immunity to unique and conserved epitopes of the Chlamydia trachomatis 60-kDa heat-shock protein (hsp60) and immunity to human hsp60 was examined in 129 women with laparoscopically verified pelvic inflammatory disease. An ELISA was used to detect antichlamydial IgG and IgA antibodies, IgG antibodies to recombinant human hsp60, and antibodies to two synthetic peptides of chlamydial hsp60. Half of the patients had antibodies to human hsp60, which correlated with the presence of antibodies to the chlamydial hsp60 peptide 260-271 homologous to the human hsp60 (P = .01). Antibodies to peptide 260-271 were associated with antichlamydial IgG (P < .0001) and IgA (P < .0001). The results suggest that the autoimmune response to human hsp60 can develop following C. trachomatis upper genital tract infection in women, probably as a consequence of an immune response to an epitope of chlamydial hsp60 cross-reactive with the human hsp60. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
177
issue
3
pages
714 - 719
publisher
Oxford University Press
external identifiers
  • pmid:9498452
  • scopus:0031887517
ISSN
1537-6613
language
English
LU publication?
no
id
5432749d-bdc7-48b1-ad0f-54497fc72df9 (old id 1113802)
alternative location
http://www.journals.uchicago.edu/doi/pdf/10.1086/514218
date added to LUP
2008-07-16 11:46:17
date last changed
2017-08-06 04:41:45
@article{5432749d-bdc7-48b1-ad0f-54497fc72df9,
  abstract     = {The association between humoral immunity to unique and conserved epitopes of the Chlamydia trachomatis 60-kDa heat-shock protein (hsp60) and immunity to human hsp60 was examined in 129 women with laparoscopically verified pelvic inflammatory disease. An ELISA was used to detect antichlamydial IgG and IgA antibodies, IgG antibodies to recombinant human hsp60, and antibodies to two synthetic peptides of chlamydial hsp60. Half of the patients had antibodies to human hsp60, which correlated with the presence of antibodies to the chlamydial hsp60 peptide 260-271 homologous to the human hsp60 (P = .01). Antibodies to peptide 260-271 were associated with antichlamydial IgG (P &lt; .0001) and IgA (P &lt; .0001). The results suggest that the autoimmune response to human hsp60 can develop following C. trachomatis upper genital tract infection in women, probably as a consequence of an immune response to an epitope of chlamydial hsp60 cross-reactive with the human hsp60.},
  author       = {Domeika, M and Domeika, K and Paavonen, J and Mårdh, Per-Anders and Witkin, S S},
  issn         = {1537-6613},
  language     = {eng},
  number       = {3},
  pages        = {714--719},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Humoral immune response to conserved epitopes of Chlamydia trachomatis and human 60-kDa heat-shock protein in women with pelvic inflammatory disease},
  volume       = {177},
  year         = {1998},
}