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Generation of clusters of free eosinophil granules (Cfegs) in seasonal allergic rhinitis

Greiff, Lennart LU ; Erjefält, Jonas LU ; Andersson, M; Svensson, Christer LU and Persson, Carl LU (1998) In Allergy 53(2). p.200-203
Abstract
Generation of clusters of free eosinophil granules (Cfegs), through lysis of eosinophils, has recently been proposed as a major paradigm for ultimate activation of airway mucosal eosinophils. In the present study involving patients with seasonal allergic rhinitis, we have investigated whether generation of Cfegs in the nasal mucosa is a feature of allergic rhinitis. Nasal mucosal biopsies were obtained before and late in a birch-pollen season, and were subjected to histochemical staining of eosinophil peroxidase. In biopsies obtained before the pollen season, a few, intact eosinophils were observed, and Cfegs were scarce. In biopsies taken during the pollen season, the numbers of eosinophils were increased about 10-fold (P < 0.05) and... (More)
Generation of clusters of free eosinophil granules (Cfegs), through lysis of eosinophils, has recently been proposed as a major paradigm for ultimate activation of airway mucosal eosinophils. In the present study involving patients with seasonal allergic rhinitis, we have investigated whether generation of Cfegs in the nasal mucosa is a feature of allergic rhinitis. Nasal mucosal biopsies were obtained before and late in a birch-pollen season, and were subjected to histochemical staining of eosinophil peroxidase. In biopsies obtained before the pollen season, a few, intact eosinophils were observed, and Cfegs were scarce. In biopsies taken during the pollen season, the numbers of eosinophils were increased about 10-fold (P < 0.05) and the Cfegs about 25-fold (P < 0.05). We conclude that generation of Cfegs is a significant feature of seasonal allergic rhinitis and that this process represents the ultimate activation of mucosal eosinophils in this disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Allergy
volume
53
issue
2
pages
200 - 203
publisher
Wiley-Blackwell
external identifiers
  • pmid:9534921
  • scopus:0031851406
ISSN
1398-9995
language
English
LU publication?
yes
id
ef87c0f5-0ff2-4046-a17a-d9161bc9d5aa (old id 1113978)
date added to LUP
2008-07-16 14:32:42
date last changed
2017-01-22 04:03:44
@article{ef87c0f5-0ff2-4046-a17a-d9161bc9d5aa,
  abstract     = {Generation of clusters of free eosinophil granules (Cfegs), through lysis of eosinophils, has recently been proposed as a major paradigm for ultimate activation of airway mucosal eosinophils. In the present study involving patients with seasonal allergic rhinitis, we have investigated whether generation of Cfegs in the nasal mucosa is a feature of allergic rhinitis. Nasal mucosal biopsies were obtained before and late in a birch-pollen season, and were subjected to histochemical staining of eosinophil peroxidase. In biopsies obtained before the pollen season, a few, intact eosinophils were observed, and Cfegs were scarce. In biopsies taken during the pollen season, the numbers of eosinophils were increased about 10-fold (P &lt; 0.05) and the Cfegs about 25-fold (P &lt; 0.05). We conclude that generation of Cfegs is a significant feature of seasonal allergic rhinitis and that this process represents the ultimate activation of mucosal eosinophils in this disease.},
  author       = {Greiff, Lennart and Erjefält, Jonas and Andersson, M and Svensson, Christer and Persson, Carl},
  issn         = {1398-9995},
  language     = {eng},
  number       = {2},
  pages        = {200--203},
  publisher    = {Wiley-Blackwell},
  series       = {Allergy},
  title        = {Generation of clusters of free eosinophil granules (Cfegs) in seasonal allergic rhinitis},
  volume       = {53},
  year         = {1998},
}