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A study of Tamm-Horsfall protein excretion in hypertensive patients and type 1 diabetic patients

Torffvit, Ole LU ; Agardh, Carl-David LU and Thulin, Thomas (1999) In Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00 33(3). p.187-191
Abstract
OBJECTIVE: The study was performed in order to evaluate to what extent hypertension or diabetes mellitus may affect the urinary excretion rate of Tamm-Horsfall protein. MATERIALS AND METHOD: The urinary excretion rates of albumin and Tamm-Horsfall protein, a measure of glomerular and distal tubular function, respectively were measured in patients with essential hypertension (n = 17) and in type 1 diabetes with (n = 20) or without nephropathy (n = 8) and in apparently healthy subjects (n = 10). RESULTS: Mean 24-h ambulatory blood pressure measurements showed higher blood pressure levels in the hypertensive (167/ 106 mmHg, p < 0.001) than in the diabetic patients with (136/84 mmHg) and without nephropathy (121/74 mmHg) and in healthy... (More)
OBJECTIVE: The study was performed in order to evaluate to what extent hypertension or diabetes mellitus may affect the urinary excretion rate of Tamm-Horsfall protein. MATERIALS AND METHOD: The urinary excretion rates of albumin and Tamm-Horsfall protein, a measure of glomerular and distal tubular function, respectively were measured in patients with essential hypertension (n = 17) and in type 1 diabetes with (n = 20) or without nephropathy (n = 8) and in apparently healthy subjects (n = 10). RESULTS: Mean 24-h ambulatory blood pressure measurements showed higher blood pressure levels in the hypertensive (167/ 106 mmHg, p < 0.001) than in the diabetic patients with (136/84 mmHg) and without nephropathy (121/74 mmHg) and in healthy subjects (122/76 mmHg). Day and night ratios of systolic and diastolic blood pressure levels were not different among the four groups. Urinary albumin excretion rate was increased in patients with hypertension (30.8 x/ 3.4 microg/min; geometric mean x/tolerance factor; p < 0.001) and diabetes with nephropathy (462 x/ 3.5 microg/min; p < 0.001) compared with diabetic patients without nephropathy and healthy subjects (4.6 x/ 1.9 and 3.7 x/ 1.5 microg/min, respectively). The Tamm-Horsfall protein excretion rate was decreased in patients with diabetic nephropathy (11.6 x/ 3.5 microg/min) compared to patients with hypertension (36.3 x/2.1 1g/min; p < 0.01), diabetes without nephropathy (39.2 x/ 2.0 microg/min; p < 0.05) and healthy subjects (63.0 x/ 1.4 microg/min; p < 0.001), whereas no differences were found among the latter three groups. CONCLUSION: These data indicate that high blood pressure may be associated with albuminuria, while a decrease in excretion rate of Tamm-Horsfall protein may be associated with diabetic nephropathy. These associations need to be studied in a larger population. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hypertension, tubular function, urinary albumin, diabetic nephropathy, Tamm-Horsfall protein, type 1 diabetes
in
Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00
volume
33
issue
3
pages
187 - 191
publisher
Taylor & Francis
external identifiers
  • pmid:10452295
  • scopus:0032790691
ISSN
0036-5599
DOI
10.1080/003655999750015970
language
English
LU publication?
yes
id
e92f9b68-3cbd-47f8-9831-8da8bed0d414 (old id 1114153)
date added to LUP
2008-07-03 14:07:57
date last changed
2017-02-19 04:17:07
@article{e92f9b68-3cbd-47f8-9831-8da8bed0d414,
  abstract     = {OBJECTIVE: The study was performed in order to evaluate to what extent hypertension or diabetes mellitus may affect the urinary excretion rate of Tamm-Horsfall protein. MATERIALS AND METHOD: The urinary excretion rates of albumin and Tamm-Horsfall protein, a measure of glomerular and distal tubular function, respectively were measured in patients with essential hypertension (n = 17) and in type 1 diabetes with (n = 20) or without nephropathy (n = 8) and in apparently healthy subjects (n = 10). RESULTS: Mean 24-h ambulatory blood pressure measurements showed higher blood pressure levels in the hypertensive (167/ 106 mmHg, p &lt; 0.001) than in the diabetic patients with (136/84 mmHg) and without nephropathy (121/74 mmHg) and in healthy subjects (122/76 mmHg). Day and night ratios of systolic and diastolic blood pressure levels were not different among the four groups. Urinary albumin excretion rate was increased in patients with hypertension (30.8 x/ 3.4 microg/min; geometric mean x/tolerance factor; p &lt; 0.001) and diabetes with nephropathy (462 x/ 3.5 microg/min; p &lt; 0.001) compared with diabetic patients without nephropathy and healthy subjects (4.6 x/ 1.9 and 3.7 x/ 1.5 microg/min, respectively). The Tamm-Horsfall protein excretion rate was decreased in patients with diabetic nephropathy (11.6 x/ 3.5 microg/min) compared to patients with hypertension (36.3 x/2.1 1g/min; p &lt; 0.01), diabetes without nephropathy (39.2 x/ 2.0 microg/min; p &lt; 0.05) and healthy subjects (63.0 x/ 1.4 microg/min; p &lt; 0.001), whereas no differences were found among the latter three groups. CONCLUSION: These data indicate that high blood pressure may be associated with albuminuria, while a decrease in excretion rate of Tamm-Horsfall protein may be associated with diabetic nephropathy. These associations need to be studied in a larger population.},
  author       = {Torffvit, Ole and Agardh, Carl-David and Thulin, Thomas},
  issn         = {0036-5599},
  keyword      = {hypertension,tubular function,urinary albumin,diabetic nephropathy,Tamm-Horsfall protein,type 1 diabetes},
  language     = {eng},
  number       = {3},
  pages        = {187--191},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00},
  title        = {A study of Tamm-Horsfall protein excretion in hypertensive patients and type 1 diabetic patients},
  url          = {http://dx.doi.org/10.1080/003655999750015970},
  volume       = {33},
  year         = {1999},
}