Perivascular cell protection in vivo and increased cell survival in vitro by the antihypertensive agent carvedilol following radiation
(1999) In European Journal of Cancer 35(8). p.1268-1273- Abstract
- Carvedilol, an antihypertensive drug with activity on adrenoceptors as well as on calcium channel activity, has recently been introduced. In the present study we investigated whether carvedilol interacts with the cytotoxicity induced by irradiation in vitro as well as in vivo. A daily injection of carvedilol in clinically relevant concentrations (3 mg/kg subcutaneously), 4 days before and 3 days after a single radiation dose of 20 Gy significantly decreased the inflammatory reaction in the rat lung, evaluated as number of inflammatory cells in the perivascular area. The density of mast cells was also slightly reduced. In vitro studies revealed that carvedilol caused different radio-protective effects, dependent on dose (1-7 Gy) used and... (More)
- Carvedilol, an antihypertensive drug with activity on adrenoceptors as well as on calcium channel activity, has recently been introduced. In the present study we investigated whether carvedilol interacts with the cytotoxicity induced by irradiation in vitro as well as in vivo. A daily injection of carvedilol in clinically relevant concentrations (3 mg/kg subcutaneously), 4 days before and 3 days after a single radiation dose of 20 Gy significantly decreased the inflammatory reaction in the rat lung, evaluated as number of inflammatory cells in the perivascular area. The density of mast cells was also slightly reduced. In vitro studies revealed that carvedilol caused different radio-protective effects, dependent on dose (1-7 Gy) used and cell line studied. The effects were especially pronounced in a malignant mesothelioma cell line (P-31), and somewhat less evident in a prostatic carcinoma cell line (PC-3). No significant effect was seen in a highly radiosensitive small cell lung cancer cell line (U-1690). Thus, carvedilol may under some circumstances interact with radiation-induced tissue reactions, most probably by a direct interaction at the cellular level. The specific explanation to the differences in sensitivity to carvedilol remains to be evaluated, but the known antioxidative properties and/or scavenging of free radicals of carvedilol may be a plausible mechanism of action. Secondary induced alterations in inflammatory response may also be considered. It is suggested that a potential interaction between drugs such as carvedilol and irradiation should be considered for clinical practice. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1114366
- author
- Jonsson, O E ; Bjermer, Leif LU ; Denekamp, J ; Grankvist, K and Henriksson, R
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- irradiation, vasoactive drugs, pneumonitis, rat, cytotoxicity, carvedilol
- in
- European Journal of Cancer
- volume
- 35
- issue
- 8
- pages
- 1268 - 1273
- publisher
- Elsevier
- external identifiers
-
- pmid:10615240
- scopus:0345086407
- ISSN
- 1879-0852
- DOI
- 10.1016/S0959-8049(99)00119-7
- language
- English
- LU publication?
- yes
- id
- 4d472a68-45cf-4e29-8683-5682df69a46e (old id 1114366)
- date added to LUP
- 2016-04-01 11:53:18
- date last changed
- 2022-01-26 19:42:47
@article{4d472a68-45cf-4e29-8683-5682df69a46e,
abstract = {{Carvedilol, an antihypertensive drug with activity on adrenoceptors as well as on calcium channel activity, has recently been introduced. In the present study we investigated whether carvedilol interacts with the cytotoxicity induced by irradiation in vitro as well as in vivo. A daily injection of carvedilol in clinically relevant concentrations (3 mg/kg subcutaneously), 4 days before and 3 days after a single radiation dose of 20 Gy significantly decreased the inflammatory reaction in the rat lung, evaluated as number of inflammatory cells in the perivascular area. The density of mast cells was also slightly reduced. In vitro studies revealed that carvedilol caused different radio-protective effects, dependent on dose (1-7 Gy) used and cell line studied. The effects were especially pronounced in a malignant mesothelioma cell line (P-31), and somewhat less evident in a prostatic carcinoma cell line (PC-3). No significant effect was seen in a highly radiosensitive small cell lung cancer cell line (U-1690). Thus, carvedilol may under some circumstances interact with radiation-induced tissue reactions, most probably by a direct interaction at the cellular level. The specific explanation to the differences in sensitivity to carvedilol remains to be evaluated, but the known antioxidative properties and/or scavenging of free radicals of carvedilol may be a plausible mechanism of action. Secondary induced alterations in inflammatory response may also be considered. It is suggested that a potential interaction between drugs such as carvedilol and irradiation should be considered for clinical practice.}},
author = {{Jonsson, O E and Bjermer, Leif and Denekamp, J and Grankvist, K and Henriksson, R}},
issn = {{1879-0852}},
keywords = {{irradiation; vasoactive drugs; pneumonitis; rat; cytotoxicity; carvedilol}},
language = {{eng}},
number = {{8}},
pages = {{1268--1273}},
publisher = {{Elsevier}},
series = {{European Journal of Cancer}},
title = {{Perivascular cell protection in vivo and increased cell survival in vitro by the antihypertensive agent carvedilol following radiation}},
url = {{http://dx.doi.org/10.1016/S0959-8049(99)00119-7}},
doi = {{10.1016/S0959-8049(99)00119-7}},
volume = {{35}},
year = {{1999}},
}