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A single-center population-based consecutive series of 1500 cytogenetically investigated adult hematological malignancies: karyotypic features in relation to morphology, age and gender

Mauritzson, Nils LU ; Johansson, Bengt LU ; Albin, Maria LU ; Billstrom, R; Ahlgren, T; Mikoczy, Zoli LU ; Nilsson, Per-Gunnar LU ; Hagmar, Lars and Mitelman, Felix LU (1999) In European Journal of Haematology 62(2). p.95-102
Abstract
During the 18-yr period 1976-93, a population-based series of 1586 adults with suspected or confirmed hematological malignancies were successfully cytogenetically investigated at a single center. Eighty-six cases were excluded due to unretrievable medical records or if analyzed only in remission or at relapse. The remaining 1500 medical records were reviewed regarding morphology and clinical parameters in order to investigate possible associations between karyotypic pattern (normal, 1, 2 or complex anomalies; specific abnormalities) and gender, age and morphological subgroups. The impact of time-period, i.e. 1976-87 vs. 1988-93, and referring center on cytogenetic findings was also studied. A total of 372 acute myeloid leukemias (AML), 389... (More)
During the 18-yr period 1976-93, a population-based series of 1586 adults with suspected or confirmed hematological malignancies were successfully cytogenetically investigated at a single center. Eighty-six cases were excluded due to unretrievable medical records or if analyzed only in remission or at relapse. The remaining 1500 medical records were reviewed regarding morphology and clinical parameters in order to investigate possible associations between karyotypic pattern (normal, 1, 2 or complex anomalies; specific abnormalities) and gender, age and morphological subgroups. The impact of time-period, i.e. 1976-87 vs. 1988-93, and referring center on cytogenetic findings was also studied. A total of 372 acute myeloid leukemias (AML), 389 myelodysplastic syndromes (MDS), 64 acute lymphoblastic leukemias (ALL) and 262 chronic myeloid leukemias (CML) were identified, altogether 1087 cases. Patients with other (n=261) or no hematological malignancies (n = 152) were excluded from the present analysis. Cytogenetic abnormalities were detected in 52% AML, 51 % MDS, 68% ALL and 97% CML, frequencies that did not differ significantly between the 2 time periods or referring centers. No significant age- or gender-related differences in karyotypic patterns were discerned in AML, MDS, ALL or CML, whereas the karyotypic patterns varied among the FAB groups in both AML (p= 0.001) and MDS (p < 0.001). The specific abnormalities t(8;21), t(15;17) and inv(16) were more common (p < 0.001) in younger AML patients and 5q- was more frequent in females with MDS (p<0.001). These findings indicate, in contrast to previous series, that neoplasia-associated karyotypic aberrations are not more common among older patients or in males. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
European Journal of Haematology
volume
62
issue
2
pages
95 - 102
publisher
Wiley-Blackwell
external identifiers
  • pmid:10052712
  • scopus:0032939412
ISSN
1600-0609
language
English
LU publication?
yes
id
10c8051d-2997-4c2c-956b-aaaea0a30203 (old id 1114699)
date added to LUP
2008-07-04 15:25:54
date last changed
2017-01-01 05:15:10
@article{10c8051d-2997-4c2c-956b-aaaea0a30203,
  abstract     = {During the 18-yr period 1976-93, a population-based series of 1586 adults with suspected or confirmed hematological malignancies were successfully cytogenetically investigated at a single center. Eighty-six cases were excluded due to unretrievable medical records or if analyzed only in remission or at relapse. The remaining 1500 medical records were reviewed regarding morphology and clinical parameters in order to investigate possible associations between karyotypic pattern (normal, 1, 2 or complex anomalies; specific abnormalities) and gender, age and morphological subgroups. The impact of time-period, i.e. 1976-87 vs. 1988-93, and referring center on cytogenetic findings was also studied. A total of 372 acute myeloid leukemias (AML), 389 myelodysplastic syndromes (MDS), 64 acute lymphoblastic leukemias (ALL) and 262 chronic myeloid leukemias (CML) were identified, altogether 1087 cases. Patients with other (n=261) or no hematological malignancies (n = 152) were excluded from the present analysis. Cytogenetic abnormalities were detected in 52% AML, 51 % MDS, 68% ALL and 97% CML, frequencies that did not differ significantly between the 2 time periods or referring centers. No significant age- or gender-related differences in karyotypic patterns were discerned in AML, MDS, ALL or CML, whereas the karyotypic patterns varied among the FAB groups in both AML (p= 0.001) and MDS (p &lt; 0.001). The specific abnormalities t(8;21), t(15;17) and inv(16) were more common (p &lt; 0.001) in younger AML patients and 5q- was more frequent in females with MDS (p&lt;0.001). These findings indicate, in contrast to previous series, that neoplasia-associated karyotypic aberrations are not more common among older patients or in males.},
  author       = {Mauritzson, Nils and Johansson, Bengt and Albin, Maria and Billstrom, R and Ahlgren, T and Mikoczy, Zoli and Nilsson, Per-Gunnar and Hagmar, Lars and Mitelman, Felix},
  issn         = {1600-0609},
  language     = {eng},
  number       = {2},
  pages        = {95--102},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology},
  title        = {A single-center population-based consecutive series of 1500 cytogenetically investigated adult hematological malignancies: karyotypic features in relation to morphology, age and gender},
  volume       = {62},
  year         = {1999},
}