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Effects of propofol on isolated human pial arteries

Wallerstedt, S M; Reinstrup, Peter LU ; Uski, Tore LU and Bodelsson, Mikael LU (1999) In Acta Anaesthesiologica Scandinavica 43(10). p.1065-1068
Abstract
BACKGROUND: The intravenous anaesthetic propofol has been reported to increase cerebral vascular resistance in vivo. The underlying mechanisms are not fully understood, but may include effects on metabolism and direct effects on the vascular smooth muscle. The present study was designed to evaluate the direct effects of propofol on human pial arteries. METHODS: We investigated the direct effect of propofol (10(-6)-10(-4) M) on isolated human pial arteries at basal tension as well as the influence on contractions induced by 5-hydroxytryptamine, prostaglandin F2alpha, noradrenaline and potassium chloride. RESULTS: Propofol did not change the basal tension. Propofol at 10(-6) and 10(-5) M did not affect the concentration-response curves of... (More)
BACKGROUND: The intravenous anaesthetic propofol has been reported to increase cerebral vascular resistance in vivo. The underlying mechanisms are not fully understood, but may include effects on metabolism and direct effects on the vascular smooth muscle. The present study was designed to evaluate the direct effects of propofol on human pial arteries. METHODS: We investigated the direct effect of propofol (10(-6)-10(-4) M) on isolated human pial arteries at basal tension as well as the influence on contractions induced by 5-hydroxytryptamine, prostaglandin F2alpha, noradrenaline and potassium chloride. RESULTS: Propofol did not change the basal tension. Propofol at 10(-6) and 10(-5) M did not affect the concentration-response curves of any of the contractile agents tested. Propofol at the supraclinical concentration 10(-4) M reduced the contractions induced by all contractile agents. CONCLUSION: Propofol reduces the tone of human pial arteries in vitro at supraclinical concentrations, but has no effect on the tone at clinically relevant concentrations. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anesthetic, intravenous, propofol, human, cerebral arteries
in
Acta Anaesthesiologica Scandinavica
volume
43
issue
10
pages
1065 - 1068
publisher
Wiley-Blackwell
external identifiers
  • pmid:10593473
  • scopus:0032723587
ISSN
0001-5172
DOI
10.1034/j.1399-6576.1999.431017.x
language
English
LU publication?
yes
id
aab63215-46e0-46f4-b33c-79902e4fef98 (old id 1114905)
alternative location
http://www3.interscience.wiley.com/cgi-bin/fulltext/119055116/PDFSTART
date added to LUP
2008-07-07 10:46:52
date last changed
2017-01-01 04:22:25
@article{aab63215-46e0-46f4-b33c-79902e4fef98,
  abstract     = {BACKGROUND: The intravenous anaesthetic propofol has been reported to increase cerebral vascular resistance in vivo. The underlying mechanisms are not fully understood, but may include effects on metabolism and direct effects on the vascular smooth muscle. The present study was designed to evaluate the direct effects of propofol on human pial arteries. METHODS: We investigated the direct effect of propofol (10(-6)-10(-4) M) on isolated human pial arteries at basal tension as well as the influence on contractions induced by 5-hydroxytryptamine, prostaglandin F2alpha, noradrenaline and potassium chloride. RESULTS: Propofol did not change the basal tension. Propofol at 10(-6) and 10(-5) M did not affect the concentration-response curves of any of the contractile agents tested. Propofol at the supraclinical concentration 10(-4) M reduced the contractions induced by all contractile agents. CONCLUSION: Propofol reduces the tone of human pial arteries in vitro at supraclinical concentrations, but has no effect on the tone at clinically relevant concentrations.},
  author       = {Wallerstedt, S M and Reinstrup, Peter and Uski, Tore and Bodelsson, Mikael},
  issn         = {0001-5172},
  keyword      = {Anesthetic,intravenous,propofol,human,cerebral arteries},
  language     = {eng},
  number       = {10},
  pages        = {1065--1068},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Effects of propofol on isolated human pial arteries},
  url          = {http://dx.doi.org/10.1034/j.1399-6576.1999.431017.x},
  volume       = {43},
  year         = {1999},
}