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Additional colloids have only a minor haemodilutive effect after surgery for aneurysmal subarachnoid haemorrhage

Ekelund, A; Säveland, Hans LU ; Reinstrup, Peter LU and Brandt, Lennart LU (1999) In British Journal of Neurosurgery 13(4). p.399-404
Abstract
Haemodilution is commonly used as prophylaxis, as well as treatment for cerebral ischaemia after aneurysmal subarachnoid haemorrhage (SAH). Thirty-six patients operated for aneurysmal SAH were evaluated retrospectively; 24 received haemodilutive therapy and 12 patients, as a control group, received no additional therapy. There was a 'spontaneous' drop in haematocrit by 22% in both groups, and a corresponding drop in haemoglobin by 23% in the treatment group and 19% in the non-haemodiluted group, during the first 4 days after the SAH. After the initial decrease the haematocrit remained stable between 0.28 and 0.33 until day 14 in both groups. The haemodilutive group had only a minor lower haematocrit level during days 8-12 as the additional... (More)
Haemodilution is commonly used as prophylaxis, as well as treatment for cerebral ischaemia after aneurysmal subarachnoid haemorrhage (SAH). Thirty-six patients operated for aneurysmal SAH were evaluated retrospectively; 24 received haemodilutive therapy and 12 patients, as a control group, received no additional therapy. There was a 'spontaneous' drop in haematocrit by 22% in both groups, and a corresponding drop in haemoglobin by 23% in the treatment group and 19% in the non-haemodiluted group, during the first 4 days after the SAH. After the initial decrease the haematocrit remained stable between 0.28 and 0.33 until day 14 in both groups. The haemodilutive group had only a minor lower haematocrit level during days 8-12 as the additional fluid resulted in increased renal excretion. This minor difference was, however, significant (p < 0.02). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Colloids, Haemodilution, Haematocrit, Subarachnoid Haemorrhage
in
British Journal of Neurosurgery
volume
13
issue
4
pages
399 - 404
publisher
Taylor & Francis
external identifiers
  • pmid:10616568
  • scopus:0032803570
ISSN
0268-8697
DOI
10.1080/02688699943529
language
English
LU publication?
yes
id
5e063ffc-5e44-4ced-8fe2-ecddc4597f55 (old id 1114908)
date added to LUP
2008-07-07 10:50:47
date last changed
2017-01-01 04:44:29
@article{5e063ffc-5e44-4ced-8fe2-ecddc4597f55,
  abstract     = {Haemodilution is commonly used as prophylaxis, as well as treatment for cerebral ischaemia after aneurysmal subarachnoid haemorrhage (SAH). Thirty-six patients operated for aneurysmal SAH were evaluated retrospectively; 24 received haemodilutive therapy and 12 patients, as a control group, received no additional therapy. There was a 'spontaneous' drop in haematocrit by 22% in both groups, and a corresponding drop in haemoglobin by 23% in the treatment group and 19% in the non-haemodiluted group, during the first 4 days after the SAH. After the initial decrease the haematocrit remained stable between 0.28 and 0.33 until day 14 in both groups. The haemodilutive group had only a minor lower haematocrit level during days 8-12 as the additional fluid resulted in increased renal excretion. This minor difference was, however, significant (p &lt; 0.02).},
  author       = {Ekelund, A and Säveland, Hans and Reinstrup, Peter and Brandt, Lennart},
  issn         = {0268-8697},
  keyword      = {Colloids,Haemodilution,Haematocrit,Subarachnoid Haemorrhage},
  language     = {eng},
  number       = {4},
  pages        = {399--404},
  publisher    = {Taylor & Francis},
  series       = {British Journal of Neurosurgery},
  title        = {Additional colloids have only a minor haemodilutive effect after surgery for aneurysmal subarachnoid haemorrhage},
  url          = {http://dx.doi.org/10.1080/02688699943529},
  volume       = {13},
  year         = {1999},
}