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DNA levels in circulating immune complexes decrease at severe SLE flares-correlation with complement component C1q

Bengtsson, Anders LU ; Nezlin, R; Shoenfeld, Y and Sturfelt, G (1999) In Journal of Autoimmunity 13(1). p.111-119
Abstract
The objective of this study was to investigate the relationship of DNA content in circulating immune complexes with disease course and activity in SLE. The DNA content in circulating immune complexes containing anti-DNA antibodies of IgG class was determined in serial samples from 28 patients with SLE by a quantitative immunochemical assay. The patients presented various active disease manifestations over 5-55 months. Disease activity (SLEDAI-score), drug treatment and ACR-criteria were recorded. Levels of anti-dsDNA, CRP, leukocytes, complement components C3, C4 and C1q were measured. Patients with severe flares and high SLEDAI scores had low Clq levels at onset of active disease manifestations. The patients with low C1q serum levels... (More)
The objective of this study was to investigate the relationship of DNA content in circulating immune complexes with disease course and activity in SLE. The DNA content in circulating immune complexes containing anti-DNA antibodies of IgG class was determined in serial samples from 28 patients with SLE by a quantitative immunochemical assay. The patients presented various active disease manifestations over 5-55 months. Disease activity (SLEDAI-score), drug treatment and ACR-criteria were recorded. Levels of anti-dsDNA, CRP, leukocytes, complement components C3, C4 and C1q were measured. Patients with severe flares and high SLEDAI scores had low Clq levels at onset of active disease manifestations. The patients with low C1q serum levels during flare (n=13) had significantly lower amounts of DNA in immune complexes than patients with normal Clq (P=0.001). Levels of DNA in immune complexes correlated with Clq at flares (r=0.62, P<0.0001) and correlated inversely with SLEDAI scores (r=-0.47, P=0.012). In conclusion, the low levels of DNA in circulating immune complexes found in severely ill SLE patients with concomitantly low serum concentrations of Clq prior to flares might be related to tissue deposition of immune complexes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
anti-DNA, C1q, DNA, immune complex, SLE
in
Journal of Autoimmunity
volume
13
issue
1
pages
111 - 119
publisher
Elsevier
external identifiers
  • pmid:10441175
  • scopus:0032793635
ISSN
0896-8411
DOI
10.1006/jaut.1999.0300
language
English
LU publication?
yes
id
06914467-07f8-492b-9585-5eca760f8409 (old id 1114930)
date added to LUP
2008-07-07 11:09:47
date last changed
2017-01-01 04:29:04
@article{06914467-07f8-492b-9585-5eca760f8409,
  abstract     = {The objective of this study was to investigate the relationship of DNA content in circulating immune complexes with disease course and activity in SLE. The DNA content in circulating immune complexes containing anti-DNA antibodies of IgG class was determined in serial samples from 28 patients with SLE by a quantitative immunochemical assay. The patients presented various active disease manifestations over 5-55 months. Disease activity (SLEDAI-score), drug treatment and ACR-criteria were recorded. Levels of anti-dsDNA, CRP, leukocytes, complement components C3, C4 and C1q were measured. Patients with severe flares and high SLEDAI scores had low Clq levels at onset of active disease manifestations. The patients with low C1q serum levels during flare (n=13) had significantly lower amounts of DNA in immune complexes than patients with normal Clq (P=0.001). Levels of DNA in immune complexes correlated with Clq at flares (r=0.62, P&lt;0.0001) and correlated inversely with SLEDAI scores (r=-0.47, P=0.012). In conclusion, the low levels of DNA in circulating immune complexes found in severely ill SLE patients with concomitantly low serum concentrations of Clq prior to flares might be related to tissue deposition of immune complexes.},
  author       = {Bengtsson, Anders and Nezlin, R and Shoenfeld, Y and Sturfelt, G},
  issn         = {0896-8411},
  keyword      = {anti-DNA,C1q,DNA,immune complex,SLE},
  language     = {eng},
  number       = {1},
  pages        = {111--119},
  publisher    = {Elsevier},
  series       = {Journal of Autoimmunity},
  title        = {DNA levels in circulating immune complexes decrease at severe SLE flares-correlation with complement component C1q},
  url          = {http://dx.doi.org/10.1006/jaut.1999.0300},
  volume       = {13},
  year         = {1999},
}