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D-arabinitol--a marker for invasive candidiasis

Christensson, Bertil LU ; Sigmundsdottir, Gudrun LU and Larsson, Lennart LU (1999) In Medical Mycology 37(6). p.391-396
Abstract
The five-carbon sugar alcohol D-arabinitol (DA) is a metabolite of most pathogenic Candida species, in vitro as well as in vivo, and can be determined by gas chromatography or enzymatic analysis. Endogenous DA and L-arabinitol (LA) are present in human body fluids, and serum DA and LA increase in renal dysfunction. In prospective clinical studies, elevated DA/LA or DA/creatine ratios in serum or urine have been found in immunocompromised, usually neutropenic, patients with invasive candidiasis. In addition, positive DA results have been obtained several days to weeks before positive blood cultures, and the normalization of DA levels has been correlated with therapeutic response in both humans and animals. However, to date, only a few... (More)
The five-carbon sugar alcohol D-arabinitol (DA) is a metabolite of most pathogenic Candida species, in vitro as well as in vivo, and can be determined by gas chromatography or enzymatic analysis. Endogenous DA and L-arabinitol (LA) are present in human body fluids, and serum DA and LA increase in renal dysfunction. In prospective clinical studies, elevated DA/LA or DA/creatine ratios in serum or urine have been found in immunocompromised, usually neutropenic, patients with invasive candidiasis. In addition, positive DA results have been obtained several days to weeks before positive blood cultures, and the normalization of DA levels has been correlated with therapeutic response in both humans and animals. However, to date, only a few prospective studies have been conducted in which adequate analytical methods were used. Thus, further investigation of various patient groups is needed to establish the applicability of the 'arabinitol method' in the diagnostic battery for invasive Candida infections. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Medical Mycology
volume
37
issue
6
pages
391 - 396
publisher
Informa Healthcare
external identifiers
  • pmid:10647119
  • scopus:0033405446
ISSN
1460-2709
DOI
10.1080/136937899100310325
language
English
LU publication?
yes
id
8aeb354d-71b3-42ec-a016-8e20e3723fc6 (old id 1114935)
date added to LUP
2008-07-07 11:14:11
date last changed
2017-01-01 04:24:41
@article{8aeb354d-71b3-42ec-a016-8e20e3723fc6,
  abstract     = {The five-carbon sugar alcohol D-arabinitol (DA) is a metabolite of most pathogenic Candida species, in vitro as well as in vivo, and can be determined by gas chromatography or enzymatic analysis. Endogenous DA and L-arabinitol (LA) are present in human body fluids, and serum DA and LA increase in renal dysfunction. In prospective clinical studies, elevated DA/LA or DA/creatine ratios in serum or urine have been found in immunocompromised, usually neutropenic, patients with invasive candidiasis. In addition, positive DA results have been obtained several days to weeks before positive blood cultures, and the normalization of DA levels has been correlated with therapeutic response in both humans and animals. However, to date, only a few prospective studies have been conducted in which adequate analytical methods were used. Thus, further investigation of various patient groups is needed to establish the applicability of the 'arabinitol method' in the diagnostic battery for invasive Candida infections.},
  author       = {Christensson, Bertil and Sigmundsdottir, Gudrun and Larsson, Lennart},
  issn         = {1460-2709},
  language     = {eng},
  number       = {6},
  pages        = {391--396},
  publisher    = {Informa Healthcare},
  series       = {Medical Mycology},
  title        = {D-arabinitol--a marker for invasive candidiasis},
  url          = {http://dx.doi.org/10.1080/136937899100310325},
  volume       = {37},
  year         = {1999},
}