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Neuronal loss in the brainstem and cerebellum--part of the normal aging process? A morphometric study of the vermis cerebelli and inferior olivary nucleus

Sjöbeck, Martin LU ; Dahlen, S and Englund, Elisabet LU (1999) In Journals of Gerontology. Series A: Biological Sciences & Medical Sciences 54(9). p.363-368
Abstract
Based on the known age-related loss of Purkinje cells (PC) in the cerebellum, this study focuses on whether a marked loss of PC occurs in individuals of very high age. The inferior olive, which is intimately connected with the cerebellum anatomically as well as functionally, was also studied. The study group included 15 nondemented and basically healthy cases aged 32-104 years. Linear neuronal density was expressed as number of PC per millimeter tissue measured in the vermis and as neuronal numbers per square millimeter tissue in the inferior olive. The linear PC density clearly decreased with increasing age, R2 = 0.82 and p < .001. The inferior olive showed a small but insignificant age-related neuronal loss. We conclude that aging... (More)
Based on the known age-related loss of Purkinje cells (PC) in the cerebellum, this study focuses on whether a marked loss of PC occurs in individuals of very high age. The inferior olive, which is intimately connected with the cerebellum anatomically as well as functionally, was also studied. The study group included 15 nondemented and basically healthy cases aged 32-104 years. Linear neuronal density was expressed as number of PC per millimeter tissue measured in the vermis and as neuronal numbers per square millimeter tissue in the inferior olive. The linear PC density clearly decreased with increasing age, R2 = 0.82 and p < .001. The inferior olive showed a small but insignificant age-related neuronal loss. We conclude that aging results in reduced PC density in the vermis cerebelli, further accentuated in the very late stages of life. (Less)
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published
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in
Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
volume
54
issue
9
pages
363 - 368
publisher
Oxford University Press
external identifiers
  • pmid:10536640
  • scopus:4243408671
ISSN
1758-535X
language
English
LU publication?
yes
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The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Pathology, (Lund) (013030000)
id
effca0c2-ad29-4a8f-820e-8a0fa669c0ea (old id 1115172)
date added to LUP
2016-04-01 17:13:37
date last changed
2020-03-03 03:44:09
@article{effca0c2-ad29-4a8f-820e-8a0fa669c0ea,
  abstract     = {Based on the known age-related loss of Purkinje cells (PC) in the cerebellum, this study focuses on whether a marked loss of PC occurs in individuals of very high age. The inferior olive, which is intimately connected with the cerebellum anatomically as well as functionally, was also studied. The study group included 15 nondemented and basically healthy cases aged 32-104 years. Linear neuronal density was expressed as number of PC per millimeter tissue measured in the vermis and as neuronal numbers per square millimeter tissue in the inferior olive. The linear PC density clearly decreased with increasing age, R2 = 0.82 and p &lt; .001. The inferior olive showed a small but insignificant age-related neuronal loss. We conclude that aging results in reduced PC density in the vermis cerebelli, further accentuated in the very late stages of life.},
  author       = {Sjöbeck, Martin and Dahlen, S and Englund, Elisabet},
  issn         = {1758-535X},
  language     = {eng},
  number       = {9},
  pages        = {363--368},
  publisher    = {Oxford University Press},
  series       = {Journals of Gerontology. Series A: Biological Sciences & Medical Sciences},
  title        = {Neuronal loss in the brainstem and cerebellum--part of the normal aging process? A morphometric study of the vermis cerebelli and inferior olivary nucleus},
  volume       = {54},
  year         = {1999},
}