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Is there a relationship between abdominal aortic aneurysms and alpha1-antitrypsin deficiency (PiZ)?

Elzouki, A N; Rydén Ahlgren, Åsa LU ; Länne, T; Sonesson, Björn LU and Eriksson, S (1999) In European Journal of Vascular and Endovascular Surgery 17(2). p.149-154
Abstract
OBJECTIVE: To determine if the frequency of alpha 1AT deficiency (PiZ) is increased in patients with abdominal aortic aneurysm (AAA), and, to investigate whether aneurysmal stiffness and other clinical characteristics differ in AAA patients with and without alpha 1AT deficiency. METHODS: We identified alpha 1AT-deficient individuals by a monoclonal-antibody ELISA technique, in 102 consecutive patients with AAA. Positive ELISA samples were further phenotyped by isoelectric focusing to differentiate between the heterozygosity (PiZ) and homozygosity (PiZZ) state. Aneurysmal diameter and stiffness was measured using echotracking sonography and blood pressure measurements. RESULTS: The frequency of heterozygous alpha 1AT deficiency (PiZ) in... (More)
OBJECTIVE: To determine if the frequency of alpha 1AT deficiency (PiZ) is increased in patients with abdominal aortic aneurysm (AAA), and, to investigate whether aneurysmal stiffness and other clinical characteristics differ in AAA patients with and without alpha 1AT deficiency. METHODS: We identified alpha 1AT-deficient individuals by a monoclonal-antibody ELISA technique, in 102 consecutive patients with AAA. Positive ELISA samples were further phenotyped by isoelectric focusing to differentiate between the heterozygosity (PiZ) and homozygosity (PiZZ) state. Aneurysmal diameter and stiffness was measured using echotracking sonography and blood pressure measurements. RESULTS: The frequency of heterozygous alpha 1AT deficiency (PiZ) in patients with AAA was similar to that in the general population (6.8% and 4.7%, respectively, p > 0.3). The frequency of popliteal and femoral aneurysm was similar in male PiZ-carriers and non-carriers with AAA, as were age at diagnosis of AAA, aneurysmal diameter, aneurysmal stiffness, and presence of factors that may be associated with AAA (i.e. smoking, hypertension, diabetes mellitus, and family history of AAA). Occurrence of ischaemic heart disease was more frequent in male non-PiZ-carriers than in male PiZ-carriers with AAA (p = 0.03). CONCLUSIONS: The frequency of alpha 1AT deficiency (PiZ) was not increased in our series of patients with AAA and patients in whom the two disorders coexisted did not appear to have different clinical characteristics except for the lower occurrence of ischaemic heart disease among the PiZ-carriers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alpha 1-antitrypsin deficiency, Aortic aneurysms
in
European Journal of Vascular and Endovascular Surgery
volume
17
issue
2
pages
149 - 154
publisher
Elsevier
external identifiers
  • pmid:10063411
  • scopus:0033082840
ISSN
1532-2165
DOI
10.1053/ejvs.1998.0740
language
English
LU publication?
yes
id
70a09251-8868-4e22-aeb9-b627fb33ad08 (old id 1115310)
date added to LUP
2008-07-07 17:04:01
date last changed
2017-04-23 04:32:06
@article{70a09251-8868-4e22-aeb9-b627fb33ad08,
  abstract     = {OBJECTIVE: To determine if the frequency of alpha 1AT deficiency (PiZ) is increased in patients with abdominal aortic aneurysm (AAA), and, to investigate whether aneurysmal stiffness and other clinical characteristics differ in AAA patients with and without alpha 1AT deficiency. METHODS: We identified alpha 1AT-deficient individuals by a monoclonal-antibody ELISA technique, in 102 consecutive patients with AAA. Positive ELISA samples were further phenotyped by isoelectric focusing to differentiate between the heterozygosity (PiZ) and homozygosity (PiZZ) state. Aneurysmal diameter and stiffness was measured using echotracking sonography and blood pressure measurements. RESULTS: The frequency of heterozygous alpha 1AT deficiency (PiZ) in patients with AAA was similar to that in the general population (6.8% and 4.7%, respectively, p > 0.3). The frequency of popliteal and femoral aneurysm was similar in male PiZ-carriers and non-carriers with AAA, as were age at diagnosis of AAA, aneurysmal diameter, aneurysmal stiffness, and presence of factors that may be associated with AAA (i.e. smoking, hypertension, diabetes mellitus, and family history of AAA). Occurrence of ischaemic heart disease was more frequent in male non-PiZ-carriers than in male PiZ-carriers with AAA (p = 0.03). CONCLUSIONS: The frequency of alpha 1AT deficiency (PiZ) was not increased in our series of patients with AAA and patients in whom the two disorders coexisted did not appear to have different clinical characteristics except for the lower occurrence of ischaemic heart disease among the PiZ-carriers.},
  author       = {Elzouki, A N and Rydén Ahlgren, Åsa and Länne, T and Sonesson, Björn and Eriksson, S},
  issn         = {1532-2165},
  keyword      = {Alpha 1-antitrypsin deficiency,Aortic aneurysms},
  language     = {eng},
  number       = {2},
  pages        = {149--154},
  publisher    = {Elsevier},
  series       = {European Journal of Vascular and Endovascular Surgery},
  title        = {Is there a relationship between abdominal aortic aneurysms and alpha1-antitrypsin deficiency (PiZ)?},
  url          = {http://dx.doi.org/10.1053/ejvs.1998.0740},
  volume       = {17},
  year         = {1999},
}