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Effect of nedocromil sodium on non-adrenergic, non-cholinergic neural responses in guinea pig bronchi in vitro

Linden, A; Bergendal, A; Lotvall, J; Skoogh, B E and Löfdahl, Claes-Göran LU (1999) In Regulatory Peptides 81(1-3). p.49-53
Abstract
OBJECTIVE: Nedocromil sodium (nedocromil) improves the clinical condition of asthmatic subjects but its mechanism of action is not fully understood. This study aimed to determine whether nedocromil alters the ability of contractile and relaxant non-adrenergic, non-cholinergic neural (NANC) responses to stabilise tone by inhibiting or potentiating these responses in bronchial smooth muscle and, if so, whether the action is on a pre- or postjunctional level. RESULTS: Nedocromil attenuated contractile but not relaxant NANC responses (elicited by electric field stimulation) significantly (P < 0.05) in guinea pig main bronchi in vitro. However, the ability of NANC responses to stabilise tone (convergence effect) was not significantly... (More)
OBJECTIVE: Nedocromil sodium (nedocromil) improves the clinical condition of asthmatic subjects but its mechanism of action is not fully understood. This study aimed to determine whether nedocromil alters the ability of contractile and relaxant non-adrenergic, non-cholinergic neural (NANC) responses to stabilise tone by inhibiting or potentiating these responses in bronchial smooth muscle and, if so, whether the action is on a pre- or postjunctional level. RESULTS: Nedocromil attenuated contractile but not relaxant NANC responses (elicited by electric field stimulation) significantly (P < 0.05) in guinea pig main bronchi in vitro. However, the ability of NANC responses to stabilise tone (convergence effect) was not significantly impaired by nedocromil. Furthermore, nedocromil did not significantly shift the concentration response curve (-log EC50) to neurokinin A (NKA), the dominating contractile NANC transmitter, or alter the maximum response to NKA (P > 0.05). Submaximum or maximum contractile responses to histamine were not markedly affected by nedocromil (P > 0.05). CONCLUSIONS: Nedocromil exerts selective neural inhibition of the contractile but not of the relaxant NANC responses on a pre-junctional level in bronchial smooth muscle. Nedocromil does not, however, markedly impair the ability of NANC response to stabilise bronchial smooth muscle tone. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Airway, Bronchoconstriction, Neurokinin A, Sensory nerves, Tachykinins
in
Regulatory Peptides
volume
81
issue
1-3
pages
49 - 53
publisher
Elsevier
external identifiers
  • pmid:10395407
  • scopus:0033039135
ISSN
1873-1686
DOI
10.1016/S0167-0115(99)00018-X
language
English
LU publication?
no
id
97751fcb-5c04-4869-b857-c7f52a898236 (old id 1115380)
date added to LUP
2008-07-08 08:55:25
date last changed
2017-01-01 04:32:45
@article{97751fcb-5c04-4869-b857-c7f52a898236,
  abstract     = {OBJECTIVE: Nedocromil sodium (nedocromil) improves the clinical condition of asthmatic subjects but its mechanism of action is not fully understood. This study aimed to determine whether nedocromil alters the ability of contractile and relaxant non-adrenergic, non-cholinergic neural (NANC) responses to stabilise tone by inhibiting or potentiating these responses in bronchial smooth muscle and, if so, whether the action is on a pre- or postjunctional level. RESULTS: Nedocromil attenuated contractile but not relaxant NANC responses (elicited by electric field stimulation) significantly (P &lt; 0.05) in guinea pig main bronchi in vitro. However, the ability of NANC responses to stabilise tone (convergence effect) was not significantly impaired by nedocromil. Furthermore, nedocromil did not significantly shift the concentration response curve (-log EC50) to neurokinin A (NKA), the dominating contractile NANC transmitter, or alter the maximum response to NKA (P &gt; 0.05). Submaximum or maximum contractile responses to histamine were not markedly affected by nedocromil (P &gt; 0.05). CONCLUSIONS: Nedocromil exerts selective neural inhibition of the contractile but not of the relaxant NANC responses on a pre-junctional level in bronchial smooth muscle. Nedocromil does not, however, markedly impair the ability of NANC response to stabilise bronchial smooth muscle tone.},
  author       = {Linden, A and Bergendal, A and Lotvall, J and Skoogh, B E and Löfdahl, Claes-Göran},
  issn         = {1873-1686},
  keyword      = {Airway,Bronchoconstriction,Neurokinin A,Sensory nerves,Tachykinins},
  language     = {eng},
  number       = {1-3},
  pages        = {49--53},
  publisher    = {Elsevier},
  series       = {Regulatory Peptides},
  title        = {Effect of nedocromil sodium on non-adrenergic, non-cholinergic neural responses in guinea pig bronchi in vitro},
  url          = {http://dx.doi.org/10.1016/S0167-0115(99)00018-X},
  volume       = {81},
  year         = {1999},
}