Epidemiologic and molecular investigation of outbreaks of hepatitis C virus infection on a pediatric oncology service
Widell, Anders LU ; Christensson, Bertil LU ; Wiebe, Thomas LU ; Schalén, Claës LU
; Hansson, Hans Bertil
; Allander, T
and Persson, M A
(1999)
In Annals of Internal Medicine
130(2).
p.130-134
- Abstract
- BACKGROUND: Despite screening of blood donors, hepatitis C virus (HCV) infection can occur in patients who receive multiple transfusions. OBJECTIVE: To clarify mechanisms of nosocomial transmission of HCV. DESIGN: Epidemiologic and molecular analyses of hepatitis C outbreaks. SETTING: Pediatric oncology ward. PATIENTS: Children with cancer. MEASUREMENTS: Epidemiologic analysis, HCV RNA detection, genotyping, and hypervariable region 1 (HVR1) sequencing. RESULTS: Ten cases of infection with acute HCV genotype 3a occurred between 1990 and 1993. Sequencing of HVR1 revealed three related strains. Despite an overhaul of hygiene procedures, a patient infected with genotype 1b generated nine subsequent infected patients in 1994. Several patients... (More)
- BACKGROUND: Despite screening of blood donors, hepatitis C virus (HCV) infection can occur in patients who receive multiple transfusions. OBJECTIVE: To clarify mechanisms of nosocomial transmission of HCV. DESIGN: Epidemiologic and molecular analyses of hepatitis C outbreaks. SETTING: Pediatric oncology ward. PATIENTS: Children with cancer. MEASUREMENTS: Epidemiologic analysis, HCV RNA detection, genotyping, and hypervariable region 1 (HVR1) sequencing. RESULTS: Ten cases of infection with acute HCV genotype 3a occurred between 1990 and 1993. Sequencing of HVR1 revealed three related strains. Despite an overhaul of hygiene procedures, a patient infected with genotype 1b generated nine subsequent infected patients in 1994. Several patients had high virus titers and strongly delayed anti-HCV antibody responses. All had permanent intravenous catheters. Multidose vials used for flushing or treatment had probably been contaminated during periods of overlapping treatment. CONCLUSIONS: Contamination of multidose vials was the most likely mode of HCV transmission; therefore, use of such vials should be restricted. Rigorous adherence to hygiene routines remains essential to preventing transmission of bloodborne infections. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1115418
- author
- Widell, Anders
LU
; Christensson, Bertil
LU
; Wiebe, Thomas
LU
; Schalén, Claës
LU
; Hansson, Hans Bertil
; Allander, T
and Persson, M A
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of Internal Medicine
- volume
- 130
- issue
- 2
- pages
- 130 - 134
- publisher
- American College of Physicians
- external identifiers
-
- pmid:10068359
- scopus:0033582180
- ISSN
- 0003-4819
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (SUS) (013008000), Clinical Microbiology, Malmö (013011000), Paediatrics (Lund) (013002000), Division of Medical Microbiology (013250400)
- id
- 359398e5-1068-4060-bbfb-154be9fdab85 (old id 1115418)
- alternative location
- http://annals.highwire.org/cgi/reprint/130/2/130
- date added to LUP
- 2016-04-01 12:20:25
- date last changed
- 2023-01-03 07:09:41
@article{359398e5-1068-4060-bbfb-154be9fdab85,
abstract = {{BACKGROUND: Despite screening of blood donors, hepatitis C virus (HCV) infection can occur in patients who receive multiple transfusions. OBJECTIVE: To clarify mechanisms of nosocomial transmission of HCV. DESIGN: Epidemiologic and molecular analyses of hepatitis C outbreaks. SETTING: Pediatric oncology ward. PATIENTS: Children with cancer. MEASUREMENTS: Epidemiologic analysis, HCV RNA detection, genotyping, and hypervariable region 1 (HVR1) sequencing. RESULTS: Ten cases of infection with acute HCV genotype 3a occurred between 1990 and 1993. Sequencing of HVR1 revealed three related strains. Despite an overhaul of hygiene procedures, a patient infected with genotype 1b generated nine subsequent infected patients in 1994. Several patients had high virus titers and strongly delayed anti-HCV antibody responses. All had permanent intravenous catheters. Multidose vials used for flushing or treatment had probably been contaminated during periods of overlapping treatment. CONCLUSIONS: Contamination of multidose vials was the most likely mode of HCV transmission; therefore, use of such vials should be restricted. Rigorous adherence to hygiene routines remains essential to preventing transmission of bloodborne infections.}},
author = {{Widell, Anders and Christensson, Bertil and Wiebe, Thomas and Schalén, Claës and Hansson, Hans Bertil and Allander, T and Persson, M A}},
issn = {{0003-4819}},
language = {{eng}},
number = {{2}},
pages = {{130--134}},
publisher = {{American College of Physicians}},
series = {{Annals of Internal Medicine}},
title = {{Epidemiologic and molecular investigation of outbreaks of hepatitis C virus infection on a pediatric oncology service}},
url = {{http://annals.highwire.org/cgi/reprint/130/2/130}},
volume = {{130}},
year = {{1999}},
}