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Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults

Vinge, Ellen LU ; Lindergård, Birger LU ; Nilsson-Ehle, Peter LU and Grubb, Anders LU (1999) In Scandinavian Journal of Clinical & Laboratory Investigation 59(8). p.587-592
Abstract
In an effort to increase our knowledge of the optimal use of serum cystatin C and creatinine as glomerular filtration rate (GFR) markers, these variables, as well as lean tissue mass and GFR, were determined in a population of 42 healthy young adults (men and women with normal GFR). Dual-energy X-ray absorptiometry and measurement of the plasma clearance of iohexol were used to measure lean tissue mass and GFR, respectively. Serum creatinine was significantly correlated to lean tissue mass (r=0.65; p < 0.0001) but not to GFR (1/creatinine vs. GFR: r=0.11; p=0.106). In contrast, serum cystatin C correlated with GFR (1/cystatin C vs. GFR: r=0.32; p=0.0387), especially in men (1/cystatin C vs. GFR: r=0.64; p=0.0055), but not to lean tissue... (More)
In an effort to increase our knowledge of the optimal use of serum cystatin C and creatinine as glomerular filtration rate (GFR) markers, these variables, as well as lean tissue mass and GFR, were determined in a population of 42 healthy young adults (men and women with normal GFR). Dual-energy X-ray absorptiometry and measurement of the plasma clearance of iohexol were used to measure lean tissue mass and GFR, respectively. Serum creatinine was significantly correlated to lean tissue mass (r=0.65; p < 0.0001) but not to GFR (1/creatinine vs. GFR: r=0.11; p=0.106). In contrast, serum cystatin C correlated with GFR (1/cystatin C vs. GFR: r=0.32; p=0.0387), especially in men (1/cystatin C vs. GFR: r=0.64; p=0.0055), but not to lean tissue mass. These results might explain previous observations that serum cystatin C seems to be a better marker for GFR than serum creatinine, particularly for individuals with small to moderate decreases in GFR. However, the results also show that the serum concentrations of both creatinine and cystatin C are determined not only by GFR, but also by other factors. Since these additional factors differ for cystatin C and creatinine, it seems justified to use serum creatinine and cystatin C in conjunction to estimate GFR, at least until it is known in what situations serum creatinine or cystatin C is the preferable marker. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Sex characteristics
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
59
issue
8
pages
587 - 592
publisher
Informa Healthcare
external identifiers
  • pmid:10691049
  • scopus:0033367864
ISSN
1502-7686
DOI
10.1080/00365519950185076
language
English
LU publication?
yes
id
672e3a75-c02f-44e1-948e-72acd3b10206 (old id 1115505)
date added to LUP
2008-07-08 10:25:48
date last changed
2017-11-05 04:31:00
@article{672e3a75-c02f-44e1-948e-72acd3b10206,
  abstract     = {In an effort to increase our knowledge of the optimal use of serum cystatin C and creatinine as glomerular filtration rate (GFR) markers, these variables, as well as lean tissue mass and GFR, were determined in a population of 42 healthy young adults (men and women with normal GFR). Dual-energy X-ray absorptiometry and measurement of the plasma clearance of iohexol were used to measure lean tissue mass and GFR, respectively. Serum creatinine was significantly correlated to lean tissue mass (r=0.65; p &lt; 0.0001) but not to GFR (1/creatinine vs. GFR: r=0.11; p=0.106). In contrast, serum cystatin C correlated with GFR (1/cystatin C vs. GFR: r=0.32; p=0.0387), especially in men (1/cystatin C vs. GFR: r=0.64; p=0.0055), but not to lean tissue mass. These results might explain previous observations that serum cystatin C seems to be a better marker for GFR than serum creatinine, particularly for individuals with small to moderate decreases in GFR. However, the results also show that the serum concentrations of both creatinine and cystatin C are determined not only by GFR, but also by other factors. Since these additional factors differ for cystatin C and creatinine, it seems justified to use serum creatinine and cystatin C in conjunction to estimate GFR, at least until it is known in what situations serum creatinine or cystatin C is the preferable marker.},
  author       = {Vinge, Ellen and Lindergård, Birger and Nilsson-Ehle, Peter and Grubb, Anders},
  issn         = {1502-7686},
  keyword      = {Sex characteristics},
  language     = {eng},
  number       = {8},
  pages        = {587--592},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults},
  url          = {http://dx.doi.org/10.1080/00365519950185076},
  volume       = {59},
  year         = {1999},
}