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Cytokine responses during mucosal infections: role in disease pathogenesis and host defence

Svanborg, Catharina LU ; Godaly, Gabriela LU and Hedlund, Maria LU (1999) In Current Opinion in Microbiology 2(1). p.99-103
Abstract
Mucosal pathogens use diverse and highly specific molecular mechanisms to activate mucosal inflammation. It may even be argued that their virulence depends on the inflammatory response that they induce. Some bacteria target epithelial cells and trigger them to produce inflammatory mediators but others cross the mucosa and activate macrophages or dendritic cells. Although systemic release of inflammatory mediators causes many symptoms and signs of infection, local chemokine production leads to the recruitment of inflammatory cells and lymphocytes that participate directly in the clearance of bacteria from mucosal sites. In this way, mucosal inflammation is a two-edged sword responsible for disease associated tissue destruction and crucial... (More)
Mucosal pathogens use diverse and highly specific molecular mechanisms to activate mucosal inflammation. It may even be argued that their virulence depends on the inflammatory response that they induce. Some bacteria target epithelial cells and trigger them to produce inflammatory mediators but others cross the mucosa and activate macrophages or dendritic cells. Although systemic release of inflammatory mediators causes many symptoms and signs of infection, local chemokine production leads to the recruitment of inflammatory cells and lymphocytes that participate directly in the clearance of bacteria from mucosal sites. In this way, mucosal inflammation is a two-edged sword responsible for disease associated tissue destruction and crucial for the antimicrobial defence. Understanding of these pathways should create tools to enhance the defence and interfere with disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Microbiology
volume
2
issue
1
pages
99 - 103
publisher
Elsevier
external identifiers
  • pmid:10047563
  • scopus:0033036459
ISSN
1879-0364
DOI
10.1016/S1369-5274(99)80017-4
language
English
LU publication?
yes
id
e107ad39-7c68-47e1-9763-fda92040f758 (old id 1115686)
date added to LUP
2008-07-08 11:33:54
date last changed
2017-10-01 03:52:50
@article{e107ad39-7c68-47e1-9763-fda92040f758,
  abstract     = {Mucosal pathogens use diverse and highly specific molecular mechanisms to activate mucosal inflammation. It may even be argued that their virulence depends on the inflammatory response that they induce. Some bacteria target epithelial cells and trigger them to produce inflammatory mediators but others cross the mucosa and activate macrophages or dendritic cells. Although systemic release of inflammatory mediators causes many symptoms and signs of infection, local chemokine production leads to the recruitment of inflammatory cells and lymphocytes that participate directly in the clearance of bacteria from mucosal sites. In this way, mucosal inflammation is a two-edged sword responsible for disease associated tissue destruction and crucial for the antimicrobial defence. Understanding of these pathways should create tools to enhance the defence and interfere with disease.},
  author       = {Svanborg, Catharina and Godaly, Gabriela and Hedlund, Maria},
  issn         = {1879-0364},
  language     = {eng},
  number       = {1},
  pages        = {99--103},
  publisher    = {Elsevier},
  series       = {Current Opinion in Microbiology},
  title        = {Cytokine responses during mucosal infections: role in disease pathogenesis and host defence},
  url          = {http://dx.doi.org/10.1016/S1369-5274(99)80017-4},
  volume       = {2},
  year         = {1999},
}