Serum sialic acid and sialoglycoproteins in asymptomatic carotid artery atherosclerosis. ARIC Investigators. Atherosclerosis Risk in Communities
(1999) In Atherosclerosis 146(1). p.65-69- Abstract
- Serum total sialic acid (S-TSA) is a recently identified risk marker for atherosclerosis and cardiovascular mortality. The purpose of this study was to evaluate the influence of three sialic acid rich glycoproteins (orosomucoid, haptoglobin, and alpha1-antitrypsin) on the relationship between S-TSA and carotid atherosclerosis. The mean S-TSA was 0.045 g/l higher among cases than controls (P<0.001) in 310 45-64 year-old male and female pairs of carotid atherosclerosis cases and disease-free controls from the Atherosclerosis Risk in Communities (ARIC) Study. Also mean serum levels of the glycoproteins were significantly higher in cases compared to controls. In a conditional multiple logistic regression model with the glycoproteins as... (More)
- Serum total sialic acid (S-TSA) is a recently identified risk marker for atherosclerosis and cardiovascular mortality. The purpose of this study was to evaluate the influence of three sialic acid rich glycoproteins (orosomucoid, haptoglobin, and alpha1-antitrypsin) on the relationship between S-TSA and carotid atherosclerosis. The mean S-TSA was 0.045 g/l higher among cases than controls (P<0.001) in 310 45-64 year-old male and female pairs of carotid atherosclerosis cases and disease-free controls from the Atherosclerosis Risk in Communities (ARIC) Study. Also mean serum levels of the glycoproteins were significantly higher in cases compared to controls. In a conditional multiple logistic regression model with the glycoproteins as independent variables, orosomucoid was correlated most strongly with case control status. However, when incorporated into the mathematical model, S-TSA not only contributed additional information as to the risk of atherosclerosis; none of the three glycoproteins contributed further once S-TSA had been accounted for. Thus, some other source of serum sialic acid or variations in the degree of sialylation of glycoproteins may be essential for understanding the relation between S-TSA and atherosclerosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1115761
- author
- Lindberg, Gunnar LU ; Råstam, Lennart LU ; Nilsson-Ehle, Peter LU ; Lundblad, A ; Ranstam, Jonas LU ; Folsom, A R and Burke, G L
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Carotid atherosclerosis, Sialic acids, Orosomucoid, Haptoglobin, greek small letter alpha1-Antitrypsin, Human, Cross-sectional study
- in
- Atherosclerosis
- volume
- 146
- issue
- 1
- pages
- 65 - 69
- publisher
- Elsevier
- external identifiers
-
- pmid:10487488
- scopus:0344500690
- ISSN
- 1879-1484
- DOI
- 10.1016/S0021-9150(99)00130-6
- language
- English
- LU publication?
- yes
- id
- 27817129-eac5-4710-864f-5d9f3d370a59 (old id 1115761)
- date added to LUP
- 2016-04-01 12:31:49
- date last changed
- 2022-01-27 06:21:55
@article{27817129-eac5-4710-864f-5d9f3d370a59, abstract = {{Serum total sialic acid (S-TSA) is a recently identified risk marker for atherosclerosis and cardiovascular mortality. The purpose of this study was to evaluate the influence of three sialic acid rich glycoproteins (orosomucoid, haptoglobin, and alpha1-antitrypsin) on the relationship between S-TSA and carotid atherosclerosis. The mean S-TSA was 0.045 g/l higher among cases than controls (P<0.001) in 310 45-64 year-old male and female pairs of carotid atherosclerosis cases and disease-free controls from the Atherosclerosis Risk in Communities (ARIC) Study. Also mean serum levels of the glycoproteins were significantly higher in cases compared to controls. In a conditional multiple logistic regression model with the glycoproteins as independent variables, orosomucoid was correlated most strongly with case control status. However, when incorporated into the mathematical model, S-TSA not only contributed additional information as to the risk of atherosclerosis; none of the three glycoproteins contributed further once S-TSA had been accounted for. Thus, some other source of serum sialic acid or variations in the degree of sialylation of glycoproteins may be essential for understanding the relation between S-TSA and atherosclerosis.}}, author = {{Lindberg, Gunnar and Råstam, Lennart and Nilsson-Ehle, Peter and Lundblad, A and Ranstam, Jonas and Folsom, A R and Burke, G L}}, issn = {{1879-1484}}, keywords = {{Carotid atherosclerosis; Sialic acids; Orosomucoid; Haptoglobin; greek small letter alpha1-Antitrypsin; Human; Cross-sectional study}}, language = {{eng}}, number = {{1}}, pages = {{65--69}}, publisher = {{Elsevier}}, series = {{Atherosclerosis}}, title = {{Serum sialic acid and sialoglycoproteins in asymptomatic carotid artery atherosclerosis. ARIC Investigators. Atherosclerosis Risk in Communities}}, url = {{http://dx.doi.org/10.1016/S0021-9150(99)00130-6}}, doi = {{10.1016/S0021-9150(99)00130-6}}, volume = {{146}}, year = {{1999}}, }