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Serum sialic acid and sialoglycoproteins in asymptomatic carotid artery atherosclerosis. ARIC Investigators. Atherosclerosis Risk in Communities

Lindberg, Gunnar LU ; Råstam, Lennart LU ; Nilsson-Ehle, Peter LU ; Lundblad, A; Ranstam, Jonas LU ; Folsom, A R and Burke, G L (1999) In Atherosclerosis 146(1). p.65-69
Abstract
Serum total sialic acid (S-TSA) is a recently identified risk marker for atherosclerosis and cardiovascular mortality. The purpose of this study was to evaluate the influence of three sialic acid rich glycoproteins (orosomucoid, haptoglobin, and alpha1-antitrypsin) on the relationship between S-TSA and carotid atherosclerosis. The mean S-TSA was 0.045 g/l higher among cases than controls (P<0.001) in 310 45-64 year-old male and female pairs of carotid atherosclerosis cases and disease-free controls from the Atherosclerosis Risk in Communities (ARIC) Study. Also mean serum levels of the glycoproteins were significantly higher in cases compared to controls. In a conditional multiple logistic regression model with the glycoproteins as... (More)
Serum total sialic acid (S-TSA) is a recently identified risk marker for atherosclerosis and cardiovascular mortality. The purpose of this study was to evaluate the influence of three sialic acid rich glycoproteins (orosomucoid, haptoglobin, and alpha1-antitrypsin) on the relationship between S-TSA and carotid atherosclerosis. The mean S-TSA was 0.045 g/l higher among cases than controls (P<0.001) in 310 45-64 year-old male and female pairs of carotid atherosclerosis cases and disease-free controls from the Atherosclerosis Risk in Communities (ARIC) Study. Also mean serum levels of the glycoproteins were significantly higher in cases compared to controls. In a conditional multiple logistic regression model with the glycoproteins as independent variables, orosomucoid was correlated most strongly with case control status. However, when incorporated into the mathematical model, S-TSA not only contributed additional information as to the risk of atherosclerosis; none of the three glycoproteins contributed further once S-TSA had been accounted for. Thus, some other source of serum sialic acid or variations in the degree of sialylation of glycoproteins may be essential for understanding the relation between S-TSA and atherosclerosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Carotid atherosclerosis, Sialic acids, Orosomucoid, Haptoglobin, greek small letter alpha1-Antitrypsin, Human, Cross-sectional study
in
Atherosclerosis
volume
146
issue
1
pages
65 - 69
publisher
Elsevier
external identifiers
  • pmid:10487488
  • scopus:0344500690
ISSN
1879-1484
DOI
10.1016/S0021-9150(99)00130-6
language
English
LU publication?
yes
id
27817129-eac5-4710-864f-5d9f3d370a59 (old id 1115761)
date added to LUP
2008-07-08 13:41:33
date last changed
2017-01-08 04:12:53
@article{27817129-eac5-4710-864f-5d9f3d370a59,
  abstract     = {Serum total sialic acid (S-TSA) is a recently identified risk marker for atherosclerosis and cardiovascular mortality. The purpose of this study was to evaluate the influence of three sialic acid rich glycoproteins (orosomucoid, haptoglobin, and alpha1-antitrypsin) on the relationship between S-TSA and carotid atherosclerosis. The mean S-TSA was 0.045 g/l higher among cases than controls (P&lt;0.001) in 310 45-64 year-old male and female pairs of carotid atherosclerosis cases and disease-free controls from the Atherosclerosis Risk in Communities (ARIC) Study. Also mean serum levels of the glycoproteins were significantly higher in cases compared to controls. In a conditional multiple logistic regression model with the glycoproteins as independent variables, orosomucoid was correlated most strongly with case control status. However, when incorporated into the mathematical model, S-TSA not only contributed additional information as to the risk of atherosclerosis; none of the three glycoproteins contributed further once S-TSA had been accounted for. Thus, some other source of serum sialic acid or variations in the degree of sialylation of glycoproteins may be essential for understanding the relation between S-TSA and atherosclerosis.},
  author       = {Lindberg, Gunnar and Råstam, Lennart and Nilsson-Ehle, Peter and Lundblad, A and Ranstam, Jonas and Folsom, A R and Burke, G L},
  issn         = {1879-1484},
  keyword      = {Carotid atherosclerosis,Sialic acids,Orosomucoid,Haptoglobin,greek small letter alpha1-Antitrypsin,Human,Cross-sectional study},
  language     = {eng},
  number       = {1},
  pages        = {65--69},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Serum sialic acid and sialoglycoproteins in asymptomatic carotid artery atherosclerosis. ARIC Investigators. Atherosclerosis Risk in Communities},
  url          = {http://dx.doi.org/10.1016/S0021-9150(99)00130-6},
  volume       = {146},
  year         = {1999},
}