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In vitro effect of fibrinogen on Candida albicans germ tube formation

Rodrigues, A; Vaz, C P; Mårdh, Per-Anders LU ; da Fonseca, A F and de Oliveira, J M (1999) In Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 107(11). p.1020-1022
Abstract
Pseudohyphae formation by Candida albicans blastoconidia, as seen in vaginal smears, is a phenotypical change commonly assumed to mean fungal invasiveness, i.e. not mere colonization. C. albicans forms germ tubes in vitro in the presence of serum. In our search for inhibitory components of germ tube formation, we decided to study fibrinogen. The inhibition of germ tube formation by clinical isolates of C. albicans was evaluated in the presence of serial concentrations of fraction I, type IV and fraction I, type Is of fibrinogen from bovine plasma. Fibrinogen showed a dose-dependent, pH-independent inhibitory effect on the germ tube formation by C. albicans.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)
volume
107
issue
11
pages
1020 - 1022
publisher
John Wiley & Sons
external identifiers
  • pmid:10598874
  • scopus:0032731463
ISSN
1600-0463
language
English
LU publication?
yes
id
53d0e784-910a-4271-897e-105420604037 (old id 1115840)
date added to LUP
2008-07-08 14:50:56
date last changed
2017-01-01 04:33:28
@article{53d0e784-910a-4271-897e-105420604037,
  abstract     = {Pseudohyphae formation by Candida albicans blastoconidia, as seen in vaginal smears, is a phenotypical change commonly assumed to mean fungal invasiveness, i.e. not mere colonization. C. albicans forms germ tubes in vitro in the presence of serum. In our search for inhibitory components of germ tube formation, we decided to study fibrinogen. The inhibition of germ tube formation by clinical isolates of C. albicans was evaluated in the presence of serial concentrations of fraction I, type IV and fraction I, type Is of fibrinogen from bovine plasma. Fibrinogen showed a dose-dependent, pH-independent inhibitory effect on the germ tube formation by C. albicans.},
  author       = {Rodrigues, A and Vaz, C P and Mårdh, Per-Anders and da Fonseca, A F and de Oliveira, J M},
  issn         = {1600-0463},
  language     = {eng},
  number       = {11},
  pages        = {1020--1022},
  publisher    = {John Wiley & Sons},
  series       = {Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)},
  title        = {In vitro effect of fibrinogen on Candida albicans germ tube formation},
  volume       = {107},
  year         = {1999},
}