Advanced

Neurturin enhances the survival of intrastriatal fetal dopaminergic transplants

Rosenblad, Carl; Kirik, Deniz LU and Björklund, Anders LU (1999) In NeuroReport 10(8). p.1783-1887
Abstract
We investigated here the effect of the novel glial cell line-derived neurotrophic factor (GDNF)-family member neurturin (NTN) on transplanted fetal dopamine (DA) neurons. Three groups of rats with complete unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal DA system received intrastriatal grafts of embryonic ventral mesencephalic tissue. Following transplantation animals received repeated injections of vehicle or NTN (0.3 microg or 3.0 microg) over three weeks posttransplantation. NTN-treated animals had significantly (1.8-fold) more tyrosine hydroxylase-immunoreactive (TH-IR) neurons. Graft volume, TH-IR cell volume and overall dopaminergic host reinnervation remained unchanged. Amphetamine-induced rotation was rapidly... (More)
We investigated here the effect of the novel glial cell line-derived neurotrophic factor (GDNF)-family member neurturin (NTN) on transplanted fetal dopamine (DA) neurons. Three groups of rats with complete unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal DA system received intrastriatal grafts of embryonic ventral mesencephalic tissue. Following transplantation animals received repeated injections of vehicle or NTN (0.3 microg or 3.0 microg) over three weeks posttransplantation. NTN-treated animals had significantly (1.8-fold) more tyrosine hydroxylase-immunoreactive (TH-IR) neurons. Graft volume, TH-IR cell volume and overall dopaminergic host reinnervation remained unchanged. Amphetamine-induced rotation was rapidly compensated in all grafted rats. We conclude that administration of NTN may be a powerful way to increase survival of transplanted fetal DA neurons. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
10
issue
8
pages
1783 - 1887
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:10501575
  • scopus:0033519586
ISSN
1473-558X
language
English
LU publication?
yes
id
803efa1d-2654-4817-9d45-86e33874585c (old id 1115889)
date added to LUP
2008-07-08 15:50:24
date last changed
2017-01-01 05:03:41
@article{803efa1d-2654-4817-9d45-86e33874585c,
  abstract     = {We investigated here the effect of the novel glial cell line-derived neurotrophic factor (GDNF)-family member neurturin (NTN) on transplanted fetal dopamine (DA) neurons. Three groups of rats with complete unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal DA system received intrastriatal grafts of embryonic ventral mesencephalic tissue. Following transplantation animals received repeated injections of vehicle or NTN (0.3 microg or 3.0 microg) over three weeks posttransplantation. NTN-treated animals had significantly (1.8-fold) more tyrosine hydroxylase-immunoreactive (TH-IR) neurons. Graft volume, TH-IR cell volume and overall dopaminergic host reinnervation remained unchanged. Amphetamine-induced rotation was rapidly compensated in all grafted rats. We conclude that administration of NTN may be a powerful way to increase survival of transplanted fetal DA neurons.},
  author       = {Rosenblad, Carl and Kirik, Deniz and Björklund, Anders},
  issn         = {1473-558X},
  language     = {eng},
  number       = {8},
  pages        = {1783--1887},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Neurturin enhances the survival of intrastriatal fetal dopaminergic transplants},
  volume       = {10},
  year         = {1999},
}