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Evaluation of heterogeneity of DNA ploidy in early gastric cancers

Osterheld, M C; Laurini, Ricardo LU ; Saraga, E and Bosman, F T (1999) In Analytical Cellular Pathology 19(2). p.67-72
Abstract
DNA ploidy has been shown to be a predictive parameter for prognosis in various solid tumours. The prognostic value of DNA-ploidy in gastric cancers is still a matter of controversy. A possible explanation for the discrepant results reported in the literature could be sampling error in tumours with multiple stemlines differing in DNA-ploidy. In order to determine whether or not such heterogeneity exists in early gastric carcinoma, we have performed DNA cytophotometry on multiple samples of a group of 17 early gastric carcinomas, of which 8 were pure intramucosal and 9 were infiltrating into the submucosa. We found an aneuploid DNA-stemline in 8 (47%) early gastric cancers, more often in tumours invading into the submucosa (5/9) than in... (More)
DNA ploidy has been shown to be a predictive parameter for prognosis in various solid tumours. The prognostic value of DNA-ploidy in gastric cancers is still a matter of controversy. A possible explanation for the discrepant results reported in the literature could be sampling error in tumours with multiple stemlines differing in DNA-ploidy. In order to determine whether or not such heterogeneity exists in early gastric carcinoma, we have performed DNA cytophotometry on multiple samples of a group of 17 early gastric carcinomas, of which 8 were pure intramucosal and 9 were infiltrating into the submucosa. We found an aneuploid DNA-stemline in 8 (47%) early gastric cancers, more often in tumours invading into the submucosa (5/9) than in purely mucosal tumours (3/8). Multiple DNA-stemlines were found more frequently in submucosally infiltrating tumours (4/5). These results confirm the presence of DNA-aneuploid early gastric carcinoma which are frequently heterogeneous and suggest that heterogeneity occurs more frequently in tumours invading the submucosa. This heterogeneity is best detected by analysing multiple samples of tumours for DNA-ploidy. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical Cellular Pathology
volume
19
issue
2
pages
67 - 72
publisher
IOS Press
external identifiers
  • pmid:10746436
  • scopus:0033493619
ISSN
0921-8912
language
English
LU publication?
no
id
9f879e6f-baf3-4319-a612-6c8df744a630 (old id 1116028)
alternative location
http://iospress.metapress.com/content/75e13v68q87wm6l3/fulltext.pdf
date added to LUP
2008-07-09 14:11:17
date last changed
2017-01-01 06:49:30
@article{9f879e6f-baf3-4319-a612-6c8df744a630,
  abstract     = {DNA ploidy has been shown to be a predictive parameter for prognosis in various solid tumours. The prognostic value of DNA-ploidy in gastric cancers is still a matter of controversy. A possible explanation for the discrepant results reported in the literature could be sampling error in tumours with multiple stemlines differing in DNA-ploidy. In order to determine whether or not such heterogeneity exists in early gastric carcinoma, we have performed DNA cytophotometry on multiple samples of a group of 17 early gastric carcinomas, of which 8 were pure intramucosal and 9 were infiltrating into the submucosa. We found an aneuploid DNA-stemline in 8 (47%) early gastric cancers, more often in tumours invading into the submucosa (5/9) than in purely mucosal tumours (3/8). Multiple DNA-stemlines were found more frequently in submucosally infiltrating tumours (4/5). These results confirm the presence of DNA-aneuploid early gastric carcinoma which are frequently heterogeneous and suggest that heterogeneity occurs more frequently in tumours invading the submucosa. This heterogeneity is best detected by analysing multiple samples of tumours for DNA-ploidy.},
  author       = {Osterheld, M C and Laurini, Ricardo and Saraga, E and Bosman, F T},
  issn         = {0921-8912},
  language     = {eng},
  number       = {2},
  pages        = {67--72},
  publisher    = {IOS Press},
  series       = {Analytical Cellular Pathology},
  title        = {Evaluation of heterogeneity of DNA ploidy in early gastric cancers},
  volume       = {19},
  year         = {1999},
}