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Periarticular tissue levels of cytokine- and endothelin-1-like immunoreactivity during the course of antigen-induced arthritis in the rat

Andersson, Sven LU ; Lexmuller, K; Alving, K and Ekstrom, G M (1999) In Inflammation Research 48(9). p.491-496
Abstract
OBJECTIVE AND DESIGN: To correlate the changes in periarticular tissue levels of pro-inflammatory cytokines and endothelin-1 (ET-1) to local pathophysiology in rats with antigen-induced arthritis (AIA). MATERIALS: The periarticular soft tissue was excised from sixty-six rats at different stages of AIA. METHODS: The samples were homogenized and the levels of immune like (LI) reactivities were determined. The levels in the arthritic joints were compared to those in non-arthritic tissue. Statistical significance was determined by ANOVA followed by Fisher PLSD. RESULTS: Compatible with a role in an early alarm reaction some mediators (tumor necrosis factor alpha-LI, interleukin-2-LI and interferon-gamma-LI) were elevated prior to the vascular... (More)
OBJECTIVE AND DESIGN: To correlate the changes in periarticular tissue levels of pro-inflammatory cytokines and endothelin-1 (ET-1) to local pathophysiology in rats with antigen-induced arthritis (AIA). MATERIALS: The periarticular soft tissue was excised from sixty-six rats at different stages of AIA. METHODS: The samples were homogenized and the levels of immune like (LI) reactivities were determined. The levels in the arthritic joints were compared to those in non-arthritic tissue. Statistical significance was determined by ANOVA followed by Fisher PLSD. RESULTS: Compatible with a role in an early alarm reaction some mediators (tumor necrosis factor alpha-LI, interleukin-2-LI and interferon-gamma-LI) were elevated prior to the vascular inflammatory activity. The curve for ET-1-LI closely followed the intensity of the inflammation whereas these parameters preceeded the elevation of interleukin-1beta-LI. CONCLUSIONS: Transient waves of different mediators appear during the course of the arthritis. This indicates the presence of active downregulatory mechanisms. Here the model could differ from human rheumatoid arthritis. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arthritis, Cytokine, Endothelin, Pannus, Rat
in
Inflammation Research
volume
48
issue
9
pages
491 - 496
publisher
Birkhaüser
external identifiers
  • pmid:10522804
  • scopus:0032842292
ISSN
1420-908X
DOI
10.1007/s000110050492
language
English
LU publication?
no
id
0fa9997b-1c30-4bf0-bd68-2eaa8e7686e7 (old id 1116048)
date added to LUP
2008-07-09 14:30:29
date last changed
2017-11-19 03:36:06
@article{0fa9997b-1c30-4bf0-bd68-2eaa8e7686e7,
  abstract     = {OBJECTIVE AND DESIGN: To correlate the changes in periarticular tissue levels of pro-inflammatory cytokines and endothelin-1 (ET-1) to local pathophysiology in rats with antigen-induced arthritis (AIA). MATERIALS: The periarticular soft tissue was excised from sixty-six rats at different stages of AIA. METHODS: The samples were homogenized and the levels of immune like (LI) reactivities were determined. The levels in the arthritic joints were compared to those in non-arthritic tissue. Statistical significance was determined by ANOVA followed by Fisher PLSD. RESULTS: Compatible with a role in an early alarm reaction some mediators (tumor necrosis factor alpha-LI, interleukin-2-LI and interferon-gamma-LI) were elevated prior to the vascular inflammatory activity. The curve for ET-1-LI closely followed the intensity of the inflammation whereas these parameters preceeded the elevation of interleukin-1beta-LI. CONCLUSIONS: Transient waves of different mediators appear during the course of the arthritis. This indicates the presence of active downregulatory mechanisms. Here the model could differ from human rheumatoid arthritis.},
  author       = {Andersson, Sven and Lexmuller, K and Alving, K and Ekstrom, G M},
  issn         = {1420-908X},
  keyword      = {Arthritis,Cytokine,Endothelin,Pannus,Rat},
  language     = {eng},
  number       = {9},
  pages        = {491--496},
  publisher    = {Birkhaüser},
  series       = {Inflammation Research},
  title        = {Periarticular tissue levels of cytokine- and endothelin-1-like immunoreactivity during the course of antigen-induced arthritis in the rat},
  url          = {http://dx.doi.org/10.1007/s000110050492},
  volume       = {48},
  year         = {1999},
}