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Prognostic implications of cytogenetic aberrations in diffuse large B-cell lymphomas

Jerkeman, Mats LU ; Johansson, Bertil LU ; Åkerman, Måns LU ; Cavallin-Ståhl, Eva LU ; Kristoffersson, Ulf LU and Mitelman, Felix LU (1999) In European Journal of Haematology 62(3). p.184-190
Abstract
A single institution series of 81 consecutive, cytogenetically analyzed, diffuse large B-cell lymphomas (DLBL), the majority of which treated with anthracycline-containing combination chemotherapy, were reviewed retrospectively to investigate whether the karyotypic pattern or certain abnormalities correlate with survival. Clonal chromosome changes were found in 79 of the 81 cases. The prognostic impact of the following aberrations, all suggested in previous studies to be associated with either shorter or longer survival, were tested: 1q21-23 breakpoints, +2/dup(2p), +3/dup(3p), +5, +6, 6q21-25 breakpoints, monosomy 7/der(7p)/i(7q), trisomy 7, 14q11-12 breakpoints, monosomy 17/der(17p)/i(17q), trisomy 18, > 4 marker chromosomes, > 4... (More)
A single institution series of 81 consecutive, cytogenetically analyzed, diffuse large B-cell lymphomas (DLBL), the majority of which treated with anthracycline-containing combination chemotherapy, were reviewed retrospectively to investigate whether the karyotypic pattern or certain abnormalities correlate with survival. Clonal chromosome changes were found in 79 of the 81 cases. The prognostic impact of the following aberrations, all suggested in previous studies to be associated with either shorter or longer survival, were tested: 1q21-23 breakpoints, +2/dup(2p), +3/dup(3p), +5, +6, 6q21-25 breakpoints, monosomy 7/der(7p)/i(7q), trisomy 7, 14q11-12 breakpoints, monosomy 17/der(17p)/i(17q), trisomy 18, > 4 marker chromosomes, > 4 breakpoints, and > or = 10 abnormalities. Univariate analysis showed that a breakpoint at 1q21-23 or trisomy 6 was associated with a shorter survival. However, when adjusted for age, stage, performance status and lactate dehydrogenase level, none of the cytogenetic aberrations had an independent prognostic value. Thus, the present investigation provides no support for any of the above-mentioned abnormalities being of prognostic importance in DLBL. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
B-Lymphocyte, Large cell lymphoma, Chromosomal aberration, Cytogenetics, Prognosis, Human, Non Hodgkin lymphoma, Lymphoproliferative syndrome, Malignant hemopathy, Genetics
in
European Journal of Haematology
volume
62
issue
3
pages
184 - 190
publisher
Wiley-Blackwell
external identifiers
  • pmid:10089896
  • scopus:0032988154
ISSN
1600-0609
language
English
LU publication?
yes
id
4f17039e-913e-4a70-bc87-c5ae64e39f94 (old id 1116066)
date added to LUP
2008-07-09 14:43:23
date last changed
2017-01-01 04:53:59
@article{4f17039e-913e-4a70-bc87-c5ae64e39f94,
  abstract     = {A single institution series of 81 consecutive, cytogenetically analyzed, diffuse large B-cell lymphomas (DLBL), the majority of which treated with anthracycline-containing combination chemotherapy, were reviewed retrospectively to investigate whether the karyotypic pattern or certain abnormalities correlate with survival. Clonal chromosome changes were found in 79 of the 81 cases. The prognostic impact of the following aberrations, all suggested in previous studies to be associated with either shorter or longer survival, were tested: 1q21-23 breakpoints, +2/dup(2p), +3/dup(3p), +5, +6, 6q21-25 breakpoints, monosomy 7/der(7p)/i(7q), trisomy 7, 14q11-12 breakpoints, monosomy 17/der(17p)/i(17q), trisomy 18, > 4 marker chromosomes, > 4 breakpoints, and > or = 10 abnormalities. Univariate analysis showed that a breakpoint at 1q21-23 or trisomy 6 was associated with a shorter survival. However, when adjusted for age, stage, performance status and lactate dehydrogenase level, none of the cytogenetic aberrations had an independent prognostic value. Thus, the present investigation provides no support for any of the above-mentioned abnormalities being of prognostic importance in DLBL.},
  author       = {Jerkeman, Mats and Johansson, Bertil and Åkerman, Måns and Cavallin-Ståhl, Eva and Kristoffersson, Ulf and Mitelman, Felix},
  issn         = {1600-0609},
  keyword      = {B-Lymphocyte,Large cell lymphoma,Chromosomal aberration,Cytogenetics,Prognosis,Human,Non Hodgkin lymphoma,Lymphoproliferative syndrome,Malignant hemopathy,Genetics},
  language     = {eng},
  number       = {3},
  pages        = {184--190},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology},
  title        = {Prognostic implications of cytogenetic aberrations in diffuse large B-cell lymphomas},
  volume       = {62},
  year         = {1999},
}