Advanced

Female gender increases stiffness of elastic but not of muscular arteries in type I diabetic patients.

Rydén Ahlgren, Åsa LU ; Sundkvist, Göran LU ; Sandgren, T and Länne, T (2002) In Clinical Physiology and Functional Imaging 22(6). p.409-415
Abstract
The reason for the particularly increased risk for cardiovascular complications in diabetic women is still unclear. We have previously found decreased distensibility of elastic arteries in type I diabetic women, indicating increased cardiac load, not seen in type I diabetic men, which might be one contributing factor. Whether the effect of gender is different in muscular arteries in type I diabetic patients has not been assessed. As estimates of arterial distensibility we measured stiffness (beta) and pressure strain elastic modulus (Ep) in the muscular common femoral artery using echo-tracking sonography in 30 women (mean age 34 years, range 20-61) and 26 men (mean age 38 years, range 22-56) with type I diabetes. The results were compared... (More)
The reason for the particularly increased risk for cardiovascular complications in diabetic women is still unclear. We have previously found decreased distensibility of elastic arteries in type I diabetic women, indicating increased cardiac load, not seen in type I diabetic men, which might be one contributing factor. Whether the effect of gender is different in muscular arteries in type I diabetic patients has not been assessed. As estimates of arterial distensibility we measured stiffness (beta) and pressure strain elastic modulus (Ep) in the muscular common femoral artery using echo-tracking sonography in 30 women (mean age 34 years, range 20-61) and 26 men (mean age 38 years, range 22-56) with type I diabetes. The results were compared with those of 89 healthy individuals of corresponding age and gender and with previously published results from elastic arteries in these patients obtained at the same occasion. The internal common femoral diameter was significantly decreased in both diabetic men and women. In sharp contrast to the highly significant decreased distensibility of the elastic abdominal aorta and common carotid artery in the type I diabetic women, the distensibility of the common femoral artery did not clearly differ between patients and controls, neither for women nor for men. Thus, the gender difference in changes of arterial distensibility found in elastic arteries was absent or far less obvious in the femoral artery. In conclusion, female gender seems to affect the mechanical properties of elastic, but not of large muscular arteries in type I diabetic patients. Thus, putative gender differences in arterial changes in type I diabetes are to be sought in elastic rather than muscular arteries. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging
volume
22
issue
6
pages
409 - 415
publisher
John Wiley and Sons
external identifiers
  • wos:000179881900009
  • pmid:12464146
  • scopus:1842869267
ISSN
1475-0961
DOI
10.1046/j.1475-097X.2002.00451.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Physiology (013242300), Endocrinology (013241500), Diabetes Epidemiology and Neuropathy (013241560)
id
470ad517-46c1-44cf-8c48-f8ff263e65cb (old id 111609)
date added to LUP
2016-04-01 12:04:09
date last changed
2021-01-06 01:08:18
@article{470ad517-46c1-44cf-8c48-f8ff263e65cb,
  abstract     = {The reason for the particularly increased risk for cardiovascular complications in diabetic women is still unclear. We have previously found decreased distensibility of elastic arteries in type I diabetic women, indicating increased cardiac load, not seen in type I diabetic men, which might be one contributing factor. Whether the effect of gender is different in muscular arteries in type I diabetic patients has not been assessed. As estimates of arterial distensibility we measured stiffness (beta) and pressure strain elastic modulus (Ep) in the muscular common femoral artery using echo-tracking sonography in 30 women (mean age 34 years, range 20-61) and 26 men (mean age 38 years, range 22-56) with type I diabetes. The results were compared with those of 89 healthy individuals of corresponding age and gender and with previously published results from elastic arteries in these patients obtained at the same occasion. The internal common femoral diameter was significantly decreased in both diabetic men and women. In sharp contrast to the highly significant decreased distensibility of the elastic abdominal aorta and common carotid artery in the type I diabetic women, the distensibility of the common femoral artery did not clearly differ between patients and controls, neither for women nor for men. Thus, the gender difference in changes of arterial distensibility found in elastic arteries was absent or far less obvious in the femoral artery. In conclusion, female gender seems to affect the mechanical properties of elastic, but not of large muscular arteries in type I diabetic patients. Thus, putative gender differences in arterial changes in type I diabetes are to be sought in elastic rather than muscular arteries.},
  author       = {Rydén Ahlgren, Åsa and Sundkvist, Göran and Sandgren, T and Länne, T},
  issn         = {1475-0961},
  language     = {eng},
  number       = {6},
  pages        = {409--415},
  publisher    = {John Wiley and Sons},
  series       = {Clinical Physiology and Functional Imaging},
  title        = {Female gender increases stiffness of elastic but not of muscular arteries in type I diabetic patients.},
  url          = {https://lup.lub.lu.se/search/ws/files/2767845/623689.pdf},
  doi          = {10.1046/j.1475-097X.2002.00451.x},
  volume       = {22},
  year         = {2002},
}