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Attenuation of electrical remodelling in chronic atrial fibrillation following oral treatment with verapamil

Meurling, Carl LU ; Ingemansson, Max LU ; Roijer, Anders LU ; Carlson, Jonas LU ; Lindholm, Carl-Johan LU ; Smideberg, Birgit LU ; Sörnmo, Leif LU ; Stridh, Martin LU and Olsson, Bertil LU (1999) In Europace 1(4). p.234-241
Abstract
AIMS: Electrical remodelling with shortening of the atrial refractory period and increased fibrillatory rate occurs after onset of atrial fibrillation and can be attenuated by pre-treatment with intravenous verapamil. The aim of the present study was to investigate whether already established fibrillatory-induced shortening of atrial fibrillatory cycle length could be reversed with oral verapamil. METHODS AND RESULTS: Thirteen patients (nine men; mean age 67 years) with chronic atrial fibrillation (CAF) were studied. The dominant atrial cycle length (DACL) was estimated non-invasively using the frequency analysis of fibrillatory ECG (FAF-ECG) method. Measurements were repeated following treatment with slow release oral verapamil. DACL... (More)
AIMS: Electrical remodelling with shortening of the atrial refractory period and increased fibrillatory rate occurs after onset of atrial fibrillation and can be attenuated by pre-treatment with intravenous verapamil. The aim of the present study was to investigate whether already established fibrillatory-induced shortening of atrial fibrillatory cycle length could be reversed with oral verapamil. METHODS AND RESULTS: Thirteen patients (nine men; mean age 67 years) with chronic atrial fibrillation (CAF) were studied. The dominant atrial cycle length (DACL) was estimated non-invasively using the frequency analysis of fibrillatory ECG (FAF-ECG) method. Measurements were repeated following treatment with slow release oral verapamil. DACL increased from 147 +/- 13 ms to 156 +/- 21 ms after 1 day (P=0.02), to 164 +/- 18 ms after 5 days (P=0.005) and finally to 160 +/- 16 ms after 6 weeks (P=0.008). CONCLUSION: Long-term oral treatment with verapamil increases the DACL significantly in patients with CAF. The prolongation is evident after 1 day and is further developed during the first 5 days of treatment. Since DACL is believed to be an index of refractoriness, the findings of the present study suggest that this treatment increases the atrial refractory period in patients with CAF. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
arrhythmia, verapamil, Atrial fibrillation, remodelling, Ca-channel
in
Europace
volume
1
issue
4
pages
234 - 241
publisher
Oxford University Press
external identifiers
  • pmid:11220560
  • scopus:0033206908
ISSN
1532-2092
DOI
10.1053/eupc.1999.0055
language
English
LU publication?
yes
id
41f9a263-3840-462e-8ef2-83186c645847 (old id 1116098)
date added to LUP
2008-07-09 15:34:00
date last changed
2017-01-01 04:56:56
@article{41f9a263-3840-462e-8ef2-83186c645847,
  abstract     = {AIMS: Electrical remodelling with shortening of the atrial refractory period and increased fibrillatory rate occurs after onset of atrial fibrillation and can be attenuated by pre-treatment with intravenous verapamil. The aim of the present study was to investigate whether already established fibrillatory-induced shortening of atrial fibrillatory cycle length could be reversed with oral verapamil. METHODS AND RESULTS: Thirteen patients (nine men; mean age 67 years) with chronic atrial fibrillation (CAF) were studied. The dominant atrial cycle length (DACL) was estimated non-invasively using the frequency analysis of fibrillatory ECG (FAF-ECG) method. Measurements were repeated following treatment with slow release oral verapamil. DACL increased from 147 +/- 13 ms to 156 +/- 21 ms after 1 day (P=0.02), to 164 +/- 18 ms after 5 days (P=0.005) and finally to 160 +/- 16 ms after 6 weeks (P=0.008). CONCLUSION: Long-term oral treatment with verapamil increases the DACL significantly in patients with CAF. The prolongation is evident after 1 day and is further developed during the first 5 days of treatment. Since DACL is believed to be an index of refractoriness, the findings of the present study suggest that this treatment increases the atrial refractory period in patients with CAF.},
  author       = {Meurling, Carl and Ingemansson, Max and Roijer, Anders and Carlson, Jonas and Lindholm, Carl-Johan and Smideberg, Birgit and Sörnmo, Leif and Stridh, Martin and Olsson, Bertil},
  issn         = {1532-2092},
  keyword      = {arrhythmia,verapamil,Atrial fibrillation,remodelling,Ca-channel},
  language     = {eng},
  number       = {4},
  pages        = {234--241},
  publisher    = {Oxford University Press},
  series       = {Europace},
  title        = {Attenuation of electrical remodelling in chronic atrial fibrillation following oral treatment with verapamil},
  url          = {http://dx.doi.org/10.1053/eupc.1999.0055},
  volume       = {1},
  year         = {1999},
}