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The prognosis for type 2 diabetic patients with heart disease. A 10-year observation study of 385 patients

Torffvit, Ole LU and Agardh, Carl-David LU (2000) In Journal of Diabetes and its Complications 14(6). p.301-306
Abstract
The objective was to study the development and progression of heart disease in type 2 diabetic patients and to evaluate the influence of revascularisation procedures on its outcome. A 10-year observation study in 385 patients attending a hospital-based outpatient clinic was performed. A total of 156/385 patients developed myocardial infarction (n=68), angina (n=44), heart failure (n=34) or died (n=109). A high mortality was seen in patients with myocardial infarction (73%) and heart failure (71%), in contrast, to patients with angina (25%). Thirty patients had a coronary angiography because of angina, out of which 23 were revascularised. Four (17%) of patients with bypass surgery or angioplasty died compared with 57 (67%) of the patients... (More)
The objective was to study the development and progression of heart disease in type 2 diabetic patients and to evaluate the influence of revascularisation procedures on its outcome. A 10-year observation study in 385 patients attending a hospital-based outpatient clinic was performed. A total of 156/385 patients developed myocardial infarction (n=68), angina (n=44), heart failure (n=34) or died (n=109). A high mortality was seen in patients with myocardial infarction (73%) and heart failure (71%), in contrast, to patients with angina (25%). Thirty patients had a coronary angiography because of angina, out of which 23 were revascularised. Four (17%) of patients with bypass surgery or angioplasty died compared with 57 (67%) of the patients with no intervention (p<0.001). The occurrence of myocardial infarction was associated with age (p<0.0001), and mean systolic (p<0.05) and diastolic (p<0.05) blood pressure and degree of albuminuria at entry (p<0.05). Heart failure was associated with age (p<0.0001), and mean HbA(1c) levels (p<0.05), while angina was associated with age only (p<0.05). Death was associated with age (p<0.0001), diabetes duration (p<0.05), mean diastolic blood pressure (p<0.05), and degree of albuminuria at entry (p<0.0001). This study shows a high incidence of heart disease in patients with type 2 diabetes. The prognosis was better in patients who had had a revascularisation procedure. Thus, a more active attitude towards revascularisation may potentially improve the prognosis for type 2 diabetic patients with atherosclerotic heart disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Angina pectoris, Myocardial infarction, Heart failure, Angioplasty, Bypass surgery, Type 2 diabetes mellitus
in
Journal of Diabetes and its Complications
volume
14
issue
6
pages
301 - 306
publisher
Elsevier
external identifiers
  • pmid:11120453
  • scopus:0033673728
ISSN
1873-460X
DOI
10.1016/S1056-8727(00)00117-3
language
English
LU publication?
yes
id
78d67889-d48c-481d-b643-fa0c88716c16 (old id 1116194)
date added to LUP
2008-07-01 09:49:23
date last changed
2017-01-01 07:15:26
@article{78d67889-d48c-481d-b643-fa0c88716c16,
  abstract     = {The objective was to study the development and progression of heart disease in type 2 diabetic patients and to evaluate the influence of revascularisation procedures on its outcome. A 10-year observation study in 385 patients attending a hospital-based outpatient clinic was performed. A total of 156/385 patients developed myocardial infarction (n=68), angina (n=44), heart failure (n=34) or died (n=109). A high mortality was seen in patients with myocardial infarction (73%) and heart failure (71%), in contrast, to patients with angina (25%). Thirty patients had a coronary angiography because of angina, out of which 23 were revascularised. Four (17%) of patients with bypass surgery or angioplasty died compared with 57 (67%) of the patients with no intervention (p&lt;0.001). The occurrence of myocardial infarction was associated with age (p&lt;0.0001), and mean systolic (p&lt;0.05) and diastolic (p&lt;0.05) blood pressure and degree of albuminuria at entry (p&lt;0.05). Heart failure was associated with age (p&lt;0.0001), and mean HbA(1c) levels (p&lt;0.05), while angina was associated with age only (p&lt;0.05). Death was associated with age (p&lt;0.0001), diabetes duration (p&lt;0.05), mean diastolic blood pressure (p&lt;0.05), and degree of albuminuria at entry (p&lt;0.0001). This study shows a high incidence of heart disease in patients with type 2 diabetes. The prognosis was better in patients who had had a revascularisation procedure. Thus, a more active attitude towards revascularisation may potentially improve the prognosis for type 2 diabetic patients with atherosclerotic heart disease.},
  author       = {Torffvit, Ole and Agardh, Carl-David},
  issn         = {1873-460X},
  keyword      = {Angina pectoris,Myocardial infarction,Heart failure,Angioplasty,Bypass surgery,Type 2 diabetes mellitus},
  language     = {eng},
  number       = {6},
  pages        = {301--306},
  publisher    = {Elsevier},
  series       = {Journal of Diabetes and its Complications},
  title        = {The prognosis for type 2 diabetic patients with heart disease. A 10-year observation study of 385 patients},
  url          = {http://dx.doi.org/10.1016/S1056-8727(00)00117-3},
  volume       = {14},
  year         = {2000},
}