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Hepatocellular carcinoma in Sweden: its association with viral hepatitis, especially with hepatitis C viral genotypes

Widell, Anders LU ; Verbaan, Hans LU ; Wejstal, Rune; Kaczynski, Jer; Kidd-Ljunggren, Karin LU and Wallerstedt, Sven (2000) In Scandinavian Journal of Infectious Diseases 32(2). p.147-152
Abstract
Viral markers of chronic hepatitis were tested for in 95 frozen serum samples from 299 patients from Malmo, Sweden, with hepatocellular carcinoma (HCC), diagnosed between 1977 and 1994. Hepatitis B analysis included anti-HBc, HBsAg and, if anti-HBc positive, HBV DNA. Hepatitis C infection analysis included anti-HCV screening, RIBA, HCV RNA and HCV genotyping. HCV genotyping was also carried out in 9 HCV-viraemic HCC-patients from Gothenburg. HCV genotype distribution in HCC cases was compared with Swedish HCV-infected blood donors. Among the 95 patients from Malmo, 28 (29%) had anti-HBc, but only 5 (5%) were chronic HBV carriers, compared with 16 (17%) with chronic hepatitis C (p = 0.021). HCV-related HCC was more common among immigrants... (More)
Viral markers of chronic hepatitis were tested for in 95 frozen serum samples from 299 patients from Malmo, Sweden, with hepatocellular carcinoma (HCC), diagnosed between 1977 and 1994. Hepatitis B analysis included anti-HBc, HBsAg and, if anti-HBc positive, HBV DNA. Hepatitis C infection analysis included anti-HCV screening, RIBA, HCV RNA and HCV genotyping. HCV genotyping was also carried out in 9 HCV-viraemic HCC-patients from Gothenburg. HCV genotype distribution in HCC cases was compared with Swedish HCV-infected blood donors. Among the 95 patients from Malmo, 28 (29%) had anti-HBc, but only 5 (5%) were chronic HBV carriers, compared with 16 (17%) with chronic hepatitis C (p = 0.021). HCV-related HCC was more common among immigrants (8/16 vs. 8/79; p < 0.001). Genotyping of 25 HCV-infected cases showed genotype 1a in 6 (24%), genotype 1b in 13 (52%), genotype 2b in 4 (16%), and genotype 3a in 2 (8.0%) patients. Genotype 1b was more common among HCC patients than among blood donors (p < 0.001), but 8 of 13 genotype 1b-infected patients were from countries where genotype 1b is predominant. Among native Swedes there was no difference between the HCV genotypes infecting blood donors and those found in HCC patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
32
issue
2
pages
147 - 152
publisher
Informa Healthcare
external identifiers
  • pmid:10826899
  • scopus:0033887470
ISSN
1651-1980
DOI
10.1080/003655400750045240
language
English
LU publication?
yes
id
2a3e1c71-d1d8-4975-8ea3-ddf266982160 (old id 1116439)
date added to LUP
2008-07-01 13:10:40
date last changed
2017-01-01 07:15:42
@article{2a3e1c71-d1d8-4975-8ea3-ddf266982160,
  abstract     = {Viral markers of chronic hepatitis were tested for in 95 frozen serum samples from 299 patients from Malmo, Sweden, with hepatocellular carcinoma (HCC), diagnosed between 1977 and 1994. Hepatitis B analysis included anti-HBc, HBsAg and, if anti-HBc positive, HBV DNA. Hepatitis C infection analysis included anti-HCV screening, RIBA, HCV RNA and HCV genotyping. HCV genotyping was also carried out in 9 HCV-viraemic HCC-patients from Gothenburg. HCV genotype distribution in HCC cases was compared with Swedish HCV-infected blood donors. Among the 95 patients from Malmo, 28 (29%) had anti-HBc, but only 5 (5%) were chronic HBV carriers, compared with 16 (17%) with chronic hepatitis C (p = 0.021). HCV-related HCC was more common among immigrants (8/16 vs. 8/79; p &lt; 0.001). Genotyping of 25 HCV-infected cases showed genotype 1a in 6 (24%), genotype 1b in 13 (52%), genotype 2b in 4 (16%), and genotype 3a in 2 (8.0%) patients. Genotype 1b was more common among HCC patients than among blood donors (p &lt; 0.001), but 8 of 13 genotype 1b-infected patients were from countries where genotype 1b is predominant. Among native Swedes there was no difference between the HCV genotypes infecting blood donors and those found in HCC patients.},
  author       = {Widell, Anders and Verbaan, Hans and Wejstal, Rune and Kaczynski, Jer and Kidd-Ljunggren, Karin and Wallerstedt, Sven},
  issn         = {1651-1980},
  language     = {eng},
  number       = {2},
  pages        = {147--152},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Hepatocellular carcinoma in Sweden: its association with viral hepatitis, especially with hepatitis C viral genotypes},
  url          = {http://dx.doi.org/10.1080/003655400750045240},
  volume       = {32},
  year         = {2000},
}