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TT virus infections among blood donors in Iceland: prevalence, genotypes, and lack of relationship to serum ALT levels

Love, A; Stanzeit, B; Li, L; Olafsdottir, E; Gudmundsson, S; Briem, H and Widell, Anders LU (2000) In Transfusion 40(3). p.306-309
Abstract
BACKGROUND: The TT virus (TTV) is a newly identified blood-borne virus. Its association with disease is still unknown, and screening of blood donors has not been implemented. Several genotypes of the TTV have been identified. STUDY DESIGN AND METHODS: Three hundred seventy healthy blood donors were randomly selected and tested for TTV by the PCR method. Sequencing of a part of the genome was performed to identify various genotypes of the virus. ALT levels were determined in both infected and uninfected individuals. RESULTS: The TT virus (TTV), was detected in the sera of 23 (6.2%) of 370 healthy Icelandic blood donors; this prevalence is lower than that reported in Japan but higher than that in Scotland. The virus was found in all groups... (More)
BACKGROUND: The TT virus (TTV) is a newly identified blood-borne virus. Its association with disease is still unknown, and screening of blood donors has not been implemented. Several genotypes of the TTV have been identified. STUDY DESIGN AND METHODS: Three hundred seventy healthy blood donors were randomly selected and tested for TTV by the PCR method. Sequencing of a part of the genome was performed to identify various genotypes of the virus. ALT levels were determined in both infected and uninfected individuals. RESULTS: The TT virus (TTV), was detected in the sera of 23 (6.2%) of 370 healthy Icelandic blood donors; this prevalence is lower than that reported in Japan but higher than that in Scotland. The virus was found in all groups over the age of 19. Sequencing and phylogenetic analysis of 202 bp from open reading frame 1 demonstrated genotypes 1b and 2b 2c and genotype 4 isolates, with the latter bearing 89-percent nucleotide homology with other genotype 4 sequences deposited at GenBank. One sample showed a mixed genotype 1b/2c infection. Serum ALT levels were within normal limits in all infected individuals. CONCLUSION: The TTV carrier state does not cause significant liver injury. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ORF = open reading frame, TTV = TT virus
in
Transfusion
volume
40
issue
3
pages
306 - 309
publisher
Wiley-Blackwell
external identifiers
  • pmid:10738031
  • scopus:0034107993
ISSN
1537-2995
DOI
10.1046/j.1537-2995.2000.40030306.x
language
English
LU publication?
yes
id
f6ddac94-72a8-423d-b784-9f3538388071 (old id 1116445)
date added to LUP
2008-07-01 13:13:52
date last changed
2017-01-01 06:56:52
@article{f6ddac94-72a8-423d-b784-9f3538388071,
  abstract     = {BACKGROUND: The TT virus (TTV) is a newly identified blood-borne virus. Its association with disease is still unknown, and screening of blood donors has not been implemented. Several genotypes of the TTV have been identified. STUDY DESIGN AND METHODS: Three hundred seventy healthy blood donors were randomly selected and tested for TTV by the PCR method. Sequencing of a part of the genome was performed to identify various genotypes of the virus. ALT levels were determined in both infected and uninfected individuals. RESULTS: The TT virus (TTV), was detected in the sera of 23 (6.2%) of 370 healthy Icelandic blood donors; this prevalence is lower than that reported in Japan but higher than that in Scotland. The virus was found in all groups over the age of 19. Sequencing and phylogenetic analysis of 202 bp from open reading frame 1 demonstrated genotypes 1b and 2b 2c and genotype 4 isolates, with the latter bearing 89-percent nucleotide homology with other genotype 4 sequences deposited at GenBank. One sample showed a mixed genotype 1b/2c infection. Serum ALT levels were within normal limits in all infected individuals. CONCLUSION: The TTV carrier state does not cause significant liver injury.},
  author       = {Love, A and Stanzeit, B and Li, L and Olafsdottir, E and Gudmundsson, S and Briem, H and Widell, Anders},
  issn         = {1537-2995},
  keyword      = {ORF = open reading frame,TTV = TT virus},
  language     = {eng},
  number       = {3},
  pages        = {306--309},
  publisher    = {Wiley-Blackwell},
  series       = {Transfusion},
  title        = {TT virus infections among blood donors in Iceland: prevalence, genotypes, and lack of relationship to serum ALT levels},
  url          = {http://dx.doi.org/10.1046/j.1537-2995.2000.40030306.x},
  volume       = {40},
  year         = {2000},
}