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Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein.

Lotharius, Julie LU and Brundin, Patrik LU (2002) In Nature Reviews Neuroscience 3(12). p.932-942
Abstract
Parkinson's disease is a devastating neurological condition that affects at least four million people. A striking feature of this disorder is the preferential loss of dopamine-producing neurons in the midbrain. Several aetiological triggers have been linked to Parkinson's disease, including genetic mutations and environmental toxins, but the pathway that leads to cell death is unknown. Recent developments have shed light on the pathogenic mechanisms that underlie the degeneration of these cells. We propose that defective sequestration of dopamine into vesicles, leading to the generation of reactive oxygen species in the cytoplasm, is a key event in the demise of dopaminergic neurons in Parkinson's disease, and might represent a common... (More)
Parkinson's disease is a devastating neurological condition that affects at least four million people. A striking feature of this disorder is the preferential loss of dopamine-producing neurons in the midbrain. Several aetiological triggers have been linked to Parkinson's disease, including genetic mutations and environmental toxins, but the pathway that leads to cell death is unknown. Recent developments have shed light on the pathogenic mechanisms that underlie the degeneration of these cells. We propose that defective sequestration of dopamine into vesicles, leading to the generation of reactive oxygen species in the cytoplasm, is a key event in the demise of dopaminergic neurons in Parkinson's disease, and might represent a common pathway that underlies both genetic and sporadic forms of the disorder. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews Neuroscience
volume
3
issue
12
pages
932 - 942
publisher
Nature Publishing Group
external identifiers
  • wos:000179600100012
  • pmid:12461550
  • scopus:0036884733
ISSN
1471-003X
DOI
10.1038/nrn983
language
English
LU publication?
yes
id
331fbd01-d253-4e09-9ece-21660fb82e70 (old id 111645)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12461550&dopt=Abstract
date added to LUP
2007-06-26 11:05:48
date last changed
2017-12-10 04:37:52
@article{331fbd01-d253-4e09-9ece-21660fb82e70,
  abstract     = {Parkinson's disease is a devastating neurological condition that affects at least four million people. A striking feature of this disorder is the preferential loss of dopamine-producing neurons in the midbrain. Several aetiological triggers have been linked to Parkinson's disease, including genetic mutations and environmental toxins, but the pathway that leads to cell death is unknown. Recent developments have shed light on the pathogenic mechanisms that underlie the degeneration of these cells. We propose that defective sequestration of dopamine into vesicles, leading to the generation of reactive oxygen species in the cytoplasm, is a key event in the demise of dopaminergic neurons in Parkinson's disease, and might represent a common pathway that underlies both genetic and sporadic forms of the disorder.},
  author       = {Lotharius, Julie and Brundin, Patrik},
  issn         = {1471-003X},
  language     = {eng},
  number       = {12},
  pages        = {932--942},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews Neuroscience},
  title        = {Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein.},
  url          = {http://dx.doi.org/10.1038/nrn983},
  volume       = {3},
  year         = {2002},
}