Advanced

alpha(1)-Microglobulin: a yellow-brown lipocalin

Åkerström, Bo LU ; Logdberg, L; Berggård, Tord LU ; Osmark, Peter LU and Lindqvist, A (2000) In Biochimica et Biophysica Acta 1482(1-2). p.172-184
Abstract
alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the alpha(1)-microglobulin-bikunin precursor, which is... (More)
alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alpha1-Microglobulin, Protein HC, Bikunin, Plasma protein, Chromophore, Free sulfhydryl, Immunosuppression
in
Biochimica et Biophysica Acta
volume
1482
issue
1-2
pages
172 - 184
publisher
Elsevier
external identifiers
  • pmid:11058759
  • scopus:0034684198
ISSN
0006-3002
DOI
10.1016/S0167-4838(00)00157-6
language
English
LU publication?
yes
id
5e930f54-aa40-4d65-b018-da936c0e3cd6 (old id 1116508)
date added to LUP
2008-07-01 13:59:40
date last changed
2017-10-22 04:32:16
@article{5e930f54-aa40-4d65-b018-da936c0e3cd6,
  abstract     = {alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo.},
  author       = {Åkerström, Bo and Logdberg, L and Berggård, Tord and Osmark, Peter and Lindqvist, A},
  issn         = {0006-3002},
  keyword      = {alpha1-Microglobulin,Protein HC,Bikunin,Plasma protein,Chromophore,Free sulfhydryl,Immunosuppression},
  language     = {eng},
  number       = {1-2},
  pages        = {172--184},
  publisher    = {Elsevier},
  series       = {Biochimica et Biophysica Acta},
  title        = {alpha(1)-Microglobulin: a yellow-brown lipocalin},
  url          = {http://dx.doi.org/10.1016/S0167-4838(00)00157-6},
  volume       = {1482},
  year         = {2000},
}