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T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis

Malmstrom, Vivianne; Bäcklund, Johan LU ; Jansson, Liselotte LU ; Kihlberg, J and Holmdahl, Rikard LU (2000) In Arthritis Research 2(4). p.315-326
Abstract
The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 256-270 epitope in cartilage, the CII-specific T cells are characterized by a partially tolerant state with low proliferative activity in vitro, but with maintained effector functions, such as IFN-gamma secretion and ability to provide B cell help. These mice were still susceptible to CIA. The response was mainly directed to the glycosylated form of the CII 256-270 peptide, rather than to the nonglycosylated peptide. Tolerance induction was rapid; transferred T cells encountered CII within a few days. CII immunization several weeks... (More)
The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 256-270 epitope in cartilage, the CII-specific T cells are characterized by a partially tolerant state with low proliferative activity in vitro, but with maintained effector functions, such as IFN-gamma secretion and ability to provide B cell help. These mice were still susceptible to CIA. The response was mainly directed to the glycosylated form of the CII 256-270 peptide, rather than to the nonglycosylated peptide. Tolerance induction was rapid; transferred T cells encountered CII within a few days. CII immunization several weeks after thymectomy of the mice did not change their susceptibility to arthritis or the induction of partial T-cell tolerance, excluding a role for recent thymic emigrants. Thus, partially tolerant CII autoreactive T cells are maintained and are crucial for the development of CIA. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
autoimmunity, rheumatoid arthritis, T lymphocytes, tolerance, transgenic
in
Arthritis Research
volume
2
issue
4
pages
315 - 326
publisher
BioMed Central
external identifiers
  • pmid:11056672
  • scopus:0034468364
ISSN
1465-9905
DOI
10.1186/ar106
language
English
LU publication?
yes
id
8ed32a6e-0388-406f-8a45-0adb98ef011f (old id 1116573)
date added to LUP
2008-07-02 08:39:27
date last changed
2017-08-13 04:21:33
@article{8ed32a6e-0388-406f-8a45-0adb98ef011f,
  abstract     = {The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 256-270 epitope in cartilage, the CII-specific T cells are characterized by a partially tolerant state with low proliferative activity in vitro, but with maintained effector functions, such as IFN-gamma secretion and ability to provide B cell help. These mice were still susceptible to CIA. The response was mainly directed to the glycosylated form of the CII 256-270 peptide, rather than to the nonglycosylated peptide. Tolerance induction was rapid; transferred T cells encountered CII within a few days. CII immunization several weeks after thymectomy of the mice did not change their susceptibility to arthritis or the induction of partial T-cell tolerance, excluding a role for recent thymic emigrants. Thus, partially tolerant CII autoreactive T cells are maintained and are crucial for the development of CIA.},
  author       = {Malmstrom, Vivianne and Bäcklund, Johan and Jansson, Liselotte and Kihlberg, J and Holmdahl, Rikard},
  issn         = {1465-9905},
  keyword      = {autoimmunity,rheumatoid arthritis,T lymphocytes,tolerance,transgenic},
  language     = {eng},
  number       = {4},
  pages        = {315--326},
  publisher    = {BioMed Central},
  series       = {Arthritis Research},
  title        = {T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis},
  url          = {http://dx.doi.org/10.1186/ar106},
  volume       = {2},
  year         = {2000},
}