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Carcinoma in situ of the breast: correlation of histopathology to immunohistochemical markers and DNA ploidy

Ottesen, G L; Christensen, I J; Larsen, J K; Larsen, J; Baldetorp, Bo LU ; Linden, Thomas; Hansen, B and Andersen, J (2000) In Breast Cancer Research and Treatment 60(3). p.219-226
Abstract
In a consecutive and unselected series of 178 cases of carcinoma in situ of the breast (CIS), comprising both ductal (DCIS) and lobular type (LCIS), and a series of 48 cases of invasive carcinoma (IC) with predominance of DCIS, the association between histopathology, immunohistochemical markers (ER, PgR, MIB-1, c-erbB-2, and p53), and DNA ploidy was investigated, in order to discriminate biologically different groups. In DCIS, significant correlation was shown between large nuclear size and comedonecrosis, both of which showed also strong association to DNA aneuploidy, high proliferation activity, low steroid receptor content, and overexpression of c-erbB-2 and p53 factors that may indicate an aggressive behavior. Small nuclear CIS,... (More)
In a consecutive and unselected series of 178 cases of carcinoma in situ of the breast (CIS), comprising both ductal (DCIS) and lobular type (LCIS), and a series of 48 cases of invasive carcinoma (IC) with predominance of DCIS, the association between histopathology, immunohistochemical markers (ER, PgR, MIB-1, c-erbB-2, and p53), and DNA ploidy was investigated, in order to discriminate biologically different groups. In DCIS, significant correlation was shown between large nuclear size and comedonecrosis, both of which showed also strong association to DNA aneuploidy, high proliferation activity, low steroid receptor content, and overexpression of c-erbB-2 and p53 factors that may indicate an aggressive behavior. Small nuclear CIS, whether LCIS or DCIS, on the contrary, were DNA diploid with low proliferation, and no cases showed overexpression of c-erbB-2 and p53. Heterogeneity with respect to the investigated parameters was also a frequent finding that may reflect a development complexity. In IC, comparison of the DCIS and the invasive component showed similar patterns. No significant differences were shown between DCIS without and with invasion. This may indicate that none of the investigated parameters on its own are essential for the event of invasion. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DNA ploidy, carcinoma in situ, breast, histopathology, immunohistochemistry, invasive carcinoma
in
Breast Cancer Research and Treatment
volume
60
issue
3
pages
219 - 226
publisher
Springer
external identifiers
  • pmid:10930109
  • scopus:0033935483
ISSN
1573-7217
DOI
10.1023/A:1006453420088
language
English
LU publication?
yes
id
581ed26c-29ce-4df6-8b3c-a56b49da4c5f (old id 1116614)
date added to LUP
2008-07-02 09:17:01
date last changed
2017-01-01 06:45:18
@article{581ed26c-29ce-4df6-8b3c-a56b49da4c5f,
  abstract     = {In a consecutive and unselected series of 178 cases of carcinoma in situ of the breast (CIS), comprising both ductal (DCIS) and lobular type (LCIS), and a series of 48 cases of invasive carcinoma (IC) with predominance of DCIS, the association between histopathology, immunohistochemical markers (ER, PgR, MIB-1, c-erbB-2, and p53), and DNA ploidy was investigated, in order to discriminate biologically different groups. In DCIS, significant correlation was shown between large nuclear size and comedonecrosis, both of which showed also strong association to DNA aneuploidy, high proliferation activity, low steroid receptor content, and overexpression of c-erbB-2 and p53 factors that may indicate an aggressive behavior. Small nuclear CIS, whether LCIS or DCIS, on the contrary, were DNA diploid with low proliferation, and no cases showed overexpression of c-erbB-2 and p53. Heterogeneity with respect to the investigated parameters was also a frequent finding that may reflect a development complexity. In IC, comparison of the DCIS and the invasive component showed similar patterns. No significant differences were shown between DCIS without and with invasion. This may indicate that none of the investigated parameters on its own are essential for the event of invasion.},
  author       = {Ottesen, G L and Christensen, I J and Larsen, J K and Larsen, J and Baldetorp, Bo and Linden, Thomas and Hansen, B and Andersen, J},
  issn         = {1573-7217},
  keyword      = {DNA ploidy,carcinoma in situ,breast,histopathology,immunohistochemistry,invasive carcinoma},
  language     = {eng},
  number       = {3},
  pages        = {219--226},
  publisher    = {Springer},
  series       = {Breast Cancer Research and Treatment},
  title        = {Carcinoma in situ of the breast: correlation of histopathology to immunohistochemical markers and DNA ploidy},
  url          = {http://dx.doi.org/10.1023/A:1006453420088},
  volume       = {60},
  year         = {2000},
}