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Results of two or five years of adjuvant tamoxifen correlated to steroid receptor and S-phase levels

Fernö, Mårten LU ; Stal, O; Baldetorp, Bo LU ; Hatschek, T; Kallstrom, A C; Malmström, Per LU ; Nordenskjold, B and Ryden, S (2000) In Breast Cancer Research and Treatment 59(1). p.69-76
Abstract
A Swedish cooperative trial demonstrated that 5 years of adjuvant tamoxifen was more beneficial than 2 years of tamoxifen in the treatment of postmenopausal women with estrogen receptor (ER) positive, early stage, invasive breast cancer. The main aim of the present study was to investigate the importance of progesterone receptor (PgR) and ER concentration levels for patients participating in the trial and still distant recurrence free two years after the primary operation. Subgroup analyses revealed that only patients with ER positive and PgR positive breast cancer had improved distant recurrence free survival (DRFS) by prolonged tamoxifen therapy (p = 0.0016). Patients with ER negative and PgR negative as well as ER positive and PgR... (More)
A Swedish cooperative trial demonstrated that 5 years of adjuvant tamoxifen was more beneficial than 2 years of tamoxifen in the treatment of postmenopausal women with estrogen receptor (ER) positive, early stage, invasive breast cancer. The main aim of the present study was to investigate the importance of progesterone receptor (PgR) and ER concentration levels for patients participating in the trial and still distant recurrence free two years after the primary operation. Subgroup analyses revealed that only patients with ER positive and PgR positive breast cancer had improved distant recurrence free survival (DRFS) by prolonged tamoxifen therapy (p = 0.0016). Patients with ER negative and PgR negative as well as ER positive and PgR negative tumors showed no significant effect of prolonged tamoxifen (p = 0.53 and p = 0.80, respectively). The percentage of ER negative and PgR positive breast cancers was too small (2.2%) for any meaningful subgroup analysis. There was a significant positive trend that the concentration level of PgR (high positive vs. low positive vs. negative) decreased the recurrence rate for those with prolonged therapy. No corresponding pattern was found for the ER content. S-phase fraction did not correlate to the recurrence rate of PgR positive breast cancers. Patients recurring during tamoxifen therapy had receptor negative tumors to a greater extent than those recurring after tamoxifen treatment. In conclusion, prolonged tamoxifen therapy for 5 years instead of 2 years was found to be beneficial for patients with ER positive and PgR positive breast cancer, whereas three extra years of tamoxifen had little or no effect for patients with ER positive but PgR negative tumors as well as for steroid receptor negative patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
estrogen and progesterone receptor, S-phase fraction, tamoxifen, breast cancer
in
Breast Cancer Research and Treatment
volume
59
issue
1
pages
69 - 76
publisher
Springer
external identifiers
  • pmid:10752681
  • scopus:0034017798
ISSN
1573-7217
DOI
10.1023/A:1006332423620
language
English
LU publication?
yes
id
5b049b3a-29eb-4e0e-b1fa-7808101e8711 (old id 1116622)
date added to LUP
2008-07-02 09:19:19
date last changed
2017-07-09 04:24:31
@article{5b049b3a-29eb-4e0e-b1fa-7808101e8711,
  abstract     = {A Swedish cooperative trial demonstrated that 5 years of adjuvant tamoxifen was more beneficial than 2 years of tamoxifen in the treatment of postmenopausal women with estrogen receptor (ER) positive, early stage, invasive breast cancer. The main aim of the present study was to investigate the importance of progesterone receptor (PgR) and ER concentration levels for patients participating in the trial and still distant recurrence free two years after the primary operation. Subgroup analyses revealed that only patients with ER positive and PgR positive breast cancer had improved distant recurrence free survival (DRFS) by prolonged tamoxifen therapy (p = 0.0016). Patients with ER negative and PgR negative as well as ER positive and PgR negative tumors showed no significant effect of prolonged tamoxifen (p = 0.53 and p = 0.80, respectively). The percentage of ER negative and PgR positive breast cancers was too small (2.2%) for any meaningful subgroup analysis. There was a significant positive trend that the concentration level of PgR (high positive vs. low positive vs. negative) decreased the recurrence rate for those with prolonged therapy. No corresponding pattern was found for the ER content. S-phase fraction did not correlate to the recurrence rate of PgR positive breast cancers. Patients recurring during tamoxifen therapy had receptor negative tumors to a greater extent than those recurring after tamoxifen treatment. In conclusion, prolonged tamoxifen therapy for 5 years instead of 2 years was found to be beneficial for patients with ER positive and PgR positive breast cancer, whereas three extra years of tamoxifen had little or no effect for patients with ER positive but PgR negative tumors as well as for steroid receptor negative patients.},
  author       = {Fernö, Mårten and Stal, O and Baldetorp, Bo and Hatschek, T and Kallstrom, A C and Malmström, Per and Nordenskjold, B and Ryden, S},
  issn         = {1573-7217},
  keyword      = {estrogen and progesterone receptor,S-phase fraction,tamoxifen,breast cancer},
  language     = {eng},
  number       = {1},
  pages        = {69--76},
  publisher    = {Springer},
  series       = {Breast Cancer Research and Treatment},
  title        = {Results of two or five years of adjuvant tamoxifen correlated to steroid receptor and S-phase levels},
  url          = {http://dx.doi.org/10.1023/A:1006332423620},
  volume       = {59},
  year         = {2000},
}