Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Developing chicken oligodendrocytes express the type IV oligodendrocyte marker T4-O in situ, but not in vitro

Anderson, Emma S ; Bjartmar, Carl ; Eriksson Linsmeier, Cecilia LU ; Westermark, Gunilla and Hildebrand, Claes (2000) In Neuroscience Letters 284(1-2). p.21-24
Abstract
Accumulating data suggest that the oligodendrocyte population includes morphological and biochemical subtypes. We recently reported that a polyclonal antiserum against an unknown antigen, the T4-O molecule, labels a subpopulation of chicken oligodendrocytes, obviously representing the type IV variety of Del Rio Hortega. The present study examines the developmental expression of the T4-O molecule in situ and in vitro. The results show that T4-O immunoreactive cells first appear at E15 in the ventral funiculus. But, oligodendrocytes cultured in vitro with or without neurones do not develop a T4-O immunoreactivity. We conclude that oligodendrocytes in the spinal cord of chicken embryos first express the T4-O molecule some time after onset of... (More)
Accumulating data suggest that the oligodendrocyte population includes morphological and biochemical subtypes. We recently reported that a polyclonal antiserum against an unknown antigen, the T4-O molecule, labels a subpopulation of chicken oligodendrocytes, obviously representing the type IV variety of Del Rio Hortega. The present study examines the developmental expression of the T4-O molecule in situ and in vitro. The results show that T4-O immunoreactive cells first appear at E15 in the ventral funiculus. But, oligodendrocytes cultured in vitro with or without neurones do not develop a T4-O immunoreactivity. We conclude that oligodendrocytes in the spinal cord of chicken embryos first express the T4-O molecule some time after onset of myelination, and that the T4-O immunoreactive phenotype does not develop in vitro. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cell culture, T4-O, Myelination, Development, White matter, Spinal cord, Oligodendrocyte, Chicken
in
Neuroscience Letters
volume
284
issue
1-2
pages
21 - 24
publisher
Elsevier
external identifiers
  • pmid:10771152
  • scopus:0034697054
ISSN
0304-3940
DOI
10.1016/S0304-3940(00)00989-7
language
English
LU publication?
no
id
282f0983-8fc6-442f-90e7-39ac415d5cb6 (old id 1116917)
date added to LUP
2016-04-01 12:02:44
date last changed
2022-01-26 22:01:48
@article{282f0983-8fc6-442f-90e7-39ac415d5cb6,
  abstract     = {{Accumulating data suggest that the oligodendrocyte population includes morphological and biochemical subtypes. We recently reported that a polyclonal antiserum against an unknown antigen, the T4-O molecule, labels a subpopulation of chicken oligodendrocytes, obviously representing the type IV variety of Del Rio Hortega. The present study examines the developmental expression of the T4-O molecule in situ and in vitro. The results show that T4-O immunoreactive cells first appear at E15 in the ventral funiculus. But, oligodendrocytes cultured in vitro with or without neurones do not develop a T4-O immunoreactivity. We conclude that oligodendrocytes in the spinal cord of chicken embryos first express the T4-O molecule some time after onset of myelination, and that the T4-O immunoreactive phenotype does not develop in vitro.}},
  author       = {{Anderson, Emma S and Bjartmar, Carl and Eriksson Linsmeier, Cecilia and Westermark, Gunilla and Hildebrand, Claes}},
  issn         = {{0304-3940}},
  keywords     = {{Cell culture; T4-O; Myelination; Development; White matter; Spinal cord; Oligodendrocyte; Chicken}},
  language     = {{eng}},
  number       = {{1-2}},
  pages        = {{21--24}},
  publisher    = {{Elsevier}},
  series       = {{Neuroscience Letters}},
  title        = {{Developing chicken oligodendrocytes express the type IV oligodendrocyte marker T4-O in situ, but not in vitro}},
  url          = {{http://dx.doi.org/10.1016/S0304-3940(00)00989-7}},
  doi          = {{10.1016/S0304-3940(00)00989-7}},
  volume       = {{284}},
  year         = {{2000}},
}