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Histologic grading in breast cancer--reproducibility between seven pathologic departments. South Sweden Breast Cancer Group

Boiesen, P; Bendahl, Pär-Ola LU ; Anagnostaki, Lola; Domanski, H; Holm, E; Idvall, Ingrid LU ; Johansson, S; Ljungberg, O; Ringberg, Anita LU and Ostberg, G, et al. (2000) In Acta Oncologica 39(1). p.41-45
Abstract
Histologic grade, including tubular formations, nuclear grade, and mitotic activity, is a well-documented prognostic factor in breast cancer. In comparison with other prognostic parameters, the evaluation of histologic grade is cheap and can be performed, in principle, in all cases of breast cancer. One possible disadvantage is that the evaluation may vary between different pathological departments. The aim of the present work was therefore to study the reproducibility of the histologic grading system by distributing haematoxylin-erythrosin-stained slides from 93 invasive breast cancers to the seven pathology departments within the southern healthcare region of Sweden. The evaluation was performed blindly and without any knowledge of other... (More)
Histologic grade, including tubular formations, nuclear grade, and mitotic activity, is a well-documented prognostic factor in breast cancer. In comparison with other prognostic parameters, the evaluation of histologic grade is cheap and can be performed, in principle, in all cases of breast cancer. One possible disadvantage is that the evaluation may vary between different pathological departments. The aim of the present work was therefore to study the reproducibility of the histologic grading system by distributing haematoxylin-erythrosin-stained slides from 93 invasive breast cancers to the seven pathology departments within the southern healthcare region of Sweden. The evaluation was performed blindly and without any knowledge of other clinical parameters. In 31% of the cases the same histologic grade was obtained for all departments. The overall mean kappa was 0.54, indicating a moderate reproducibility. Of the three factors included in histologic grade, the agreement was best for tubular formations and poorest for nuclear grade and mitotic activity. The overall moderate reproducibility should be considered when the clinical usefulness of histologic grading is compared with other prognostic instruments. (Less)
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published
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Acta Oncologica
volume
39
issue
1
pages
41 - 45
publisher
Taylor & Francis
external identifiers
  • pmid:10752652
  • scopus:0033994180
ISSN
1651-226X
DOI
10.1080/028418600430950
language
English
LU publication?
yes
id
72abf2a1-d78d-43c8-82a8-e0d5a58a02b4 (old id 1116973)
date added to LUP
2008-07-02 14:26:25
date last changed
2017-08-06 04:34:06
@article{72abf2a1-d78d-43c8-82a8-e0d5a58a02b4,
  abstract     = {Histologic grade, including tubular formations, nuclear grade, and mitotic activity, is a well-documented prognostic factor in breast cancer. In comparison with other prognostic parameters, the evaluation of histologic grade is cheap and can be performed, in principle, in all cases of breast cancer. One possible disadvantage is that the evaluation may vary between different pathological departments. The aim of the present work was therefore to study the reproducibility of the histologic grading system by distributing haematoxylin-erythrosin-stained slides from 93 invasive breast cancers to the seven pathology departments within the southern healthcare region of Sweden. The evaluation was performed blindly and without any knowledge of other clinical parameters. In 31% of the cases the same histologic grade was obtained for all departments. The overall mean kappa was 0.54, indicating a moderate reproducibility. Of the three factors included in histologic grade, the agreement was best for tubular formations and poorest for nuclear grade and mitotic activity. The overall moderate reproducibility should be considered when the clinical usefulness of histologic grading is compared with other prognostic instruments.},
  author       = {Boiesen, P and Bendahl, Pär-Ola and Anagnostaki, Lola and Domanski, H and Holm, E and Idvall, Ingrid and Johansson, S and Ljungberg, O and Ringberg, Anita and Ostberg, G and Fernö, Mårten},
  issn         = {1651-226X},
  language     = {eng},
  number       = {1},
  pages        = {41--45},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Histologic grading in breast cancer--reproducibility between seven pathologic departments. South Sweden Breast Cancer Group},
  url          = {http://dx.doi.org/10.1080/028418600430950},
  volume       = {39},
  year         = {2000},
}