PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
(2000) In Nature Cell Biology 2(5). p.302-309- Abstract
- Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1117142
- author
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Platelet-Derived Growth Factor, Myocardium, Molecular Sequence Data, Mice, Mesoderm, Lymphokines, Ligands, Kidney, Insects, In Situ Hybridization, Humans, Developmental, Gene Expression Regulation, Gene Expression, Epithelial Cells, Endopeptidases, Animals, COS Cells, Protein Structure, Tertiary, RNA, Messenger, Rabbits, Receptor, Platelet-Derived Growth Factor alpha, Sequence Homology, Amino Acid, Transgenes
- in
- Nature Cell Biology
- volume
- 2
- issue
- 5
- pages
- 302 - 309
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:10806482
- scopus:0033776193
- ISSN
- 1465-7392
- DOI
- 10.1038/35010579
- language
- English
- LU publication?
- no
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012)
- id
- 55726e0a-464d-418e-bb30-8288256cfc37 (old id 1117142)
- alternative location
- http://dx.doi.org/10.1038/35010579
- http://www.ncbi.nlm.nih.gov/pubmed/10806482
- date added to LUP
- 2016-04-01 16:28:28
- date last changed
- 2022-04-15 04:50:13
@article{55726e0a-464d-418e-bb30-8288256cfc37, abstract = {{Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.}}, author = {{Li, X. and Pontén, A. and Aase, K. and Karlsson, L. and Abramsson, A. and Uutela, M. and Bäckström, G. and Hellström, M. and Ehrencrona, Hans and Li, H. and Soriano, P. and Betsholtz, C. and Heldin, C. H. and Alitalo, K. and Ostman, A. and Eriksson, U.}}, issn = {{1465-7392}}, keywords = {{Platelet-Derived Growth Factor; Myocardium; Molecular Sequence Data; Mice; Mesoderm; Lymphokines; Ligands; Kidney; Insects; In Situ Hybridization; Humans; Developmental; Gene Expression Regulation; Gene Expression; Epithelial Cells; Endopeptidases; Animals; COS Cells; Protein Structure; Tertiary; RNA; Messenger; Rabbits; Receptor; Platelet-Derived Growth Factor alpha; Sequence Homology; Amino Acid; Transgenes}}, language = {{eng}}, number = {{5}}, pages = {{302--309}}, publisher = {{Nature Publishing Group}}, series = {{Nature Cell Biology}}, title = {{PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.}}, url = {{http://dx.doi.org/10.1038/35010579}}, doi = {{10.1038/35010579}}, volume = {{2}}, year = {{2000}}, }