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PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

Li, X.; Pontén, A.; Aase, K.; Karlsson, L.; Abramsson, A.; Uutela, M.; Bäckström, G.; Hellström, M.; Ehrencrona, Hans LU and Li, H., et al. (2000) In Nature Cell Biology 2(5). p.302-309
Abstract
Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.
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keywords
Platelet-Derived Growth Factor, Myocardium, Molecular Sequence Data, Mice, Mesoderm, Lymphokines, Ligands, Kidney, Insects, In Situ Hybridization, Humans, Developmental, Gene Expression Regulation, Gene Expression, Epithelial Cells, Endopeptidases, Animals, COS Cells, Protein Structure, Tertiary, RNA, Messenger, Rabbits, Receptor, Platelet-Derived Growth Factor alpha, Sequence Homology, Amino Acid, Transgenes
in
Nature Cell Biology
volume
2
issue
5
pages
302 - 309
publisher
Nature Publishing Group
external identifiers
  • pmid:10806482
  • scopus:0033776193
ISSN
1465-7392
DOI
10.1038/35010579
language
English
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55726e0a-464d-418e-bb30-8288256cfc37 (old id 1117142)
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http://dx.doi.org/10.1038/35010579
http://www.ncbi.nlm.nih.gov/pubmed/10806482
date added to LUP
2013-10-21 10:52:52
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2017-11-12 03:59:23
@article{55726e0a-464d-418e-bb30-8288256cfc37,
  abstract     = {Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.},
  author       = {Li, X. and Pontén, A. and Aase, K. and Karlsson, L. and Abramsson, A. and Uutela, M. and Bäckström, G. and Hellström, M. and Ehrencrona, Hans and Li, H. and Soriano, P. and Betsholtz, C. and Heldin, C. H. and Alitalo, K. and Ostman, A. and Eriksson, U.},
  issn         = {1465-7392},
  keyword      = {Platelet-Derived Growth Factor,Myocardium,Molecular Sequence Data,Mice,Mesoderm,Lymphokines,Ligands,Kidney,Insects,In Situ Hybridization,Humans,Developmental,Gene Expression Regulation,Gene Expression,Epithelial Cells,Endopeptidases,Animals,COS Cells,Protein Structure,Tertiary,RNA,Messenger,Rabbits,Receptor,Platelet-Derived Growth Factor alpha,Sequence Homology,Amino Acid,Transgenes},
  language     = {eng},
  number       = {5},
  pages        = {302--309},
  publisher    = {Nature Publishing Group},
  series       = {Nature Cell Biology},
  title        = {PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.},
  url          = {http://dx.doi.org/10.1038/35010579},
  volume       = {2},
  year         = {2000},
}