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Acute myeloid leukemia and clonal chromosome aberrations in relation to past exposure to organic solvents

Albin, Maria LU ; Björk, Jonas LU ; Welinder, H; Tinnerberg, H; Mauritzson, N; Johansson, B; Billstrom, R; Stromberg, U; Mikoczy, Z and Ahlgren, T, et al. (2000) In Scandinavian Journal of Work, Environment and Health 26(6). p.482-491
Abstract
OBJECTIVES: The effects of occupational and leisure-time exposures on the risk of acute myeloid leukemia (AML) were investigated with emphasis on clonal chromosome aberrations (CCA) and morphological subtypes. METHODS: Consecutively diagnosed cases of AML (N=333) and 1 population referent per case were retrospectively included in the study. Information on worktasks, companies, and leisure-time activities was obtained with telephone interviews. Exposure probability and intensity were assessed by occupational hygienists. Associations were evaluated with logistic regression. RESULTS: Exposure to organic solvents was associated with an increased risk of AML [low exposure: OR 1.5 (95% confidence interval (95% CI) 1.0-2.3, moderate-high... (More)
OBJECTIVES: The effects of occupational and leisure-time exposures on the risk of acute myeloid leukemia (AML) were investigated with emphasis on clonal chromosome aberrations (CCA) and morphological subtypes. METHODS: Consecutively diagnosed cases of AML (N=333) and 1 population referent per case were retrospectively included in the study. Information on worktasks, companies, and leisure-time activities was obtained with telephone interviews. Exposure probability and intensity were assessed by occupational hygienists. Associations were evaluated with logistic regression. RESULTS: Exposure to organic solvents was associated with an increased risk of AML [low exposure: OR 1.5 (95% confidence interval (95% CI) 1.0-2.3, moderate-high exposure: OR 2.3 (95% CI 1.0-5.0)]. For exposure to solvents, but not to benzene, the OR was 1.2 (95% CI 0.69-2.0) for "low" and 2.7 (95% CI 1.0-7.3) for "moderate-high" exposure. The observed effects increased with intensity and duration of exposure. The estimated effects were higher for patients >60 years of age at the time of diagnosis. The effect of exposure to organic solvents was not differential with regard to morphology [except possibly erythroleukemia: OR 4.2, 95% CI 1.0-17 or the presence of CCA in general]. No increased risk for AML with complex CCA or with total or partial losses of chromosomes 5 or 7 were observed, but a higher risk was found for AML with trisomy 8 (OR 11, 95% CI 2.7-42) as the sole aberration. CONCLUSIONS: Exposure to organic solvents was associated with an increased risk of AML. This association was not due to benzene exposure alone and may be modified by age. Furthermore, specific associations with trisomy 8, and possibly also erythroleukemia, were suggested. (Less)
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published
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keywords
cytogenetic, case-referent study, benzene, age, effect modification, erythroleukemia, occupational limit value, population attributable risk, trisomy 8
in
Scandinavian Journal of Work, Environment and Health
volume
26
issue
6
pages
482 - 491
publisher
Finnish Institute of Occupational Health
external identifiers
  • pmid:11201395
  • scopus:0034522597
ISSN
0355-3140
language
English
LU publication?
yes
id
7bd8262e-80fd-4eae-a192-37b7b128655b (old id 1117202)
date added to LUP
2008-07-03 09:27:36
date last changed
2017-07-30 03:39:20
@article{7bd8262e-80fd-4eae-a192-37b7b128655b,
  abstract     = {OBJECTIVES: The effects of occupational and leisure-time exposures on the risk of acute myeloid leukemia (AML) were investigated with emphasis on clonal chromosome aberrations (CCA) and morphological subtypes. METHODS: Consecutively diagnosed cases of AML (N=333) and 1 population referent per case were retrospectively included in the study. Information on worktasks, companies, and leisure-time activities was obtained with telephone interviews. Exposure probability and intensity were assessed by occupational hygienists. Associations were evaluated with logistic regression. RESULTS: Exposure to organic solvents was associated with an increased risk of AML [low exposure: OR 1.5 (95% confidence interval (95% CI) 1.0-2.3, moderate-high exposure: OR 2.3 (95% CI 1.0-5.0)]. For exposure to solvents, but not to benzene, the OR was 1.2 (95% CI 0.69-2.0) for "low" and 2.7 (95% CI 1.0-7.3) for "moderate-high" exposure. The observed effects increased with intensity and duration of exposure. The estimated effects were higher for patients >60 years of age at the time of diagnosis. The effect of exposure to organic solvents was not differential with regard to morphology [except possibly erythroleukemia: OR 4.2, 95% CI 1.0-17 or the presence of CCA in general]. No increased risk for AML with complex CCA or with total or partial losses of chromosomes 5 or 7 were observed, but a higher risk was found for AML with trisomy 8 (OR 11, 95% CI 2.7-42) as the sole aberration. CONCLUSIONS: Exposure to organic solvents was associated with an increased risk of AML. This association was not due to benzene exposure alone and may be modified by age. Furthermore, specific associations with trisomy 8, and possibly also erythroleukemia, were suggested.},
  author       = {Albin, Maria and Björk, Jonas and Welinder, H and Tinnerberg, H and Mauritzson, N and Johansson, B and Billstrom, R and Stromberg, U and Mikoczy, Z and Ahlgren, T and Nilsson, P G and Mitelman, F and Hagmar, L},
  issn         = {0355-3140},
  keyword      = {cytogenetic,case-referent study,benzene,age,effect modification,erythroleukemia,occupational limit value,population attributable risk,trisomy 8},
  language     = {eng},
  number       = {6},
  pages        = {482--491},
  publisher    = {Finnish Institute of Occupational Health},
  series       = {Scandinavian Journal of Work, Environment and Health},
  title        = {Acute myeloid leukemia and clonal chromosome aberrations in relation to past exposure to organic solvents},
  volume       = {26},
  year         = {2000},
}