Activation and cross-reactivity pattern of a new allergen in adhesive plaster
(2000) In Contact Dermatitis 42(1). p.11-17- Abstract
- N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described.... (More)
- N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described. Studies of the hydrolysis of the copper inhibitor at physiological pH showed rapid formation of 1,2-diaminopropane under biomimetic conditions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1117714
- author
- Bergendorff, Ola LU and Hansson, Christer LU
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Contact Dermatitis
- volume
- 42
- issue
- 1
- pages
- 11 - 17
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:10644019
- scopus:0033984118
- ISSN
- 0105-1873
- DOI
- 10.1034/j.1600-0536.2000.042001011.x
- language
- English
- LU publication?
- yes
- id
- ee8dfa38-336f-4cbe-9716-17dad02fcac0 (old id 1117714)
- date added to LUP
- 2016-04-01 12:02:46
- date last changed
- 2022-08-13 18:23:40
@article{ee8dfa38-336f-4cbe-9716-17dad02fcac0,
abstract = {{N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described. Studies of the hydrolysis of the copper inhibitor at physiological pH showed rapid formation of 1,2-diaminopropane under biomimetic conditions.}},
author = {{Bergendorff, Ola and Hansson, Christer}},
issn = {{0105-1873}},
language = {{eng}},
number = {{1}},
pages = {{11--17}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Activation and cross-reactivity pattern of a new allergen in adhesive plaster}},
url = {{http://dx.doi.org/10.1034/j.1600-0536.2000.042001011.x}},
doi = {{10.1034/j.1600-0536.2000.042001011.x}},
volume = {{42}},
year = {{2000}},
}