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Activation and cross-reactivity pattern of a new allergen in adhesive plaster

Bergendorff, Ola LU and Hansson, Christer LU (2000) In Contact Dermatitis 42(1). p.11-17
Abstract
N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described.... (More)
N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described. Studies of the hydrolysis of the copper inhibitor at physiological pH showed rapid formation of 1,2-diaminopropane under biomimetic conditions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Contact Dermatitis
volume
42
issue
1
pages
11 - 17
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:10644019
  • scopus:0033984118
ISSN
0105-1873
DOI
10.1034/j.1600-0536.2000.042001011.x
language
English
LU publication?
yes
id
ee8dfa38-336f-4cbe-9716-17dad02fcac0 (old id 1117714)
date added to LUP
2008-06-25 09:30:22
date last changed
2017-01-01 04:47:08
@article{ee8dfa38-336f-4cbe-9716-17dad02fcac0,
  abstract     = {N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described. Studies of the hydrolysis of the copper inhibitor at physiological pH showed rapid formation of 1,2-diaminopropane under biomimetic conditions.},
  author       = {Bergendorff, Ola and Hansson, Christer},
  issn         = {0105-1873},
  language     = {eng},
  number       = {1},
  pages        = {11--17},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Activation and cross-reactivity pattern of a new allergen in adhesive plaster},
  url          = {http://dx.doi.org/10.1034/j.1600-0536.2000.042001011.x},
  volume       = {42},
  year         = {2000},
}