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Emphysematous lesions and lung function in healthy smokers 60 years of age

Tylen, U; Boijsen, M; Ekberg-Jansson, A; Bake, B and Löfdahl, Claes-Göran LU (2000) In Respiratory Medicine 94(1). p.38-43
Abstract
We aimed to study the occurrence of emphysematous lesions in symptom free smoking men of about 60 years of age and in a matching group of never-smoking men and the relationship between pulmonary changes at high resolution computed tomography (HRCT) and lung function tests. Our investigation included 57 smoking and 32 never-smoking healthy men from a randomized epidemiological study. HRCT was performed at full inspiration with a 1.5 mm slice thickness and a 3 cm inter-slice distance. Evaluation was made by two radiologists unaware of smoking history. Emphysematous lesions were scored visually. Pulmonary function tests were performed including spirometry and diffusion capacity test (DLCO). Emphysematous changes were demonstrated in 25 of 57... (More)
We aimed to study the occurrence of emphysematous lesions in symptom free smoking men of about 60 years of age and in a matching group of never-smoking men and the relationship between pulmonary changes at high resolution computed tomography (HRCT) and lung function tests. Our investigation included 57 smoking and 32 never-smoking healthy men from a randomized epidemiological study. HRCT was performed at full inspiration with a 1.5 mm slice thickness and a 3 cm inter-slice distance. Evaluation was made by two radiologists unaware of smoking history. Emphysematous lesions were scored visually. Pulmonary function tests were performed including spirometry and diffusion capacity test (DLCO). Emphysematous changes were demonstrated in 25 of 57 smokers but in only one never-smoker. DLCO/VA was the most sensitive test for early emphysematous lesions. It also correlated with radiographical scoring. Emphysematous lesions were evident in 44% of the healthy symptom free smokers. HRCT may reveal early emphysematous lesions in smokers before clinical symptoms have developed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Respiratory Medicine
volume
94
issue
1
pages
38 - 43
publisher
Elsevier
external identifiers
  • pmid:10714477
  • scopus:0033996324
ISSN
1532-3064
DOI
10.1053/rmed.1999.0690
language
English
LU publication?
yes
id
580f38da-d6dc-435b-9c1b-ee4bdc8a51cf (old id 1117801)
date added to LUP
2008-06-25 08:29:00
date last changed
2017-01-01 07:06:53
@article{580f38da-d6dc-435b-9c1b-ee4bdc8a51cf,
  abstract     = {We aimed to study the occurrence of emphysematous lesions in symptom free smoking men of about 60 years of age and in a matching group of never-smoking men and the relationship between pulmonary changes at high resolution computed tomography (HRCT) and lung function tests. Our investigation included 57 smoking and 32 never-smoking healthy men from a randomized epidemiological study. HRCT was performed at full inspiration with a 1.5 mm slice thickness and a 3 cm inter-slice distance. Evaluation was made by two radiologists unaware of smoking history. Emphysematous lesions were scored visually. Pulmonary function tests were performed including spirometry and diffusion capacity test (DLCO). Emphysematous changes were demonstrated in 25 of 57 smokers but in only one never-smoker. DLCO/VA was the most sensitive test for early emphysematous lesions. It also correlated with radiographical scoring. Emphysematous lesions were evident in 44% of the healthy symptom free smokers. HRCT may reveal early emphysematous lesions in smokers before clinical symptoms have developed.},
  author       = {Tylen, U and Boijsen, M and Ekberg-Jansson, A and Bake, B and Löfdahl, Claes-Göran},
  issn         = {1532-3064},
  language     = {eng},
  number       = {1},
  pages        = {38--43},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Emphysematous lesions and lung function in healthy smokers 60 years of age},
  url          = {http://dx.doi.org/10.1053/rmed.1999.0690},
  volume       = {94},
  year         = {2000},
}