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Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14

Nilsson, Niclas LU ; Tryselius, Ylva LU and Owman, Christer LU (2000) In Biochemical and Biophysical Research Communications 274(2). p.383-388
Abstract
The genomic region containing the genes encoding the first leukotriene B(4) receptor, BLTR, as well as the recently cloned second leukotriene B(4)-activated receptor, BLTR2, was mapped by (a) sequence analysis of a human bacterial artificial chromosome (BAC) library containing a 15-kb segment corresponding to chromosome 14q11. 2-12 where the BLTR/BLTR2 genes were previously shown to be located, together with (b) sequence analysis of 83 expressed sequence tags (ESTs) from this region. The BLTR gene includes four different 5' untranslated regions (UTRs) and a mutual acceptor site for the exon containing the intronless open reading frame. The BLTR2 gene is intronless and overlapped by a 5' UTR splice version of BLTR and, on the reverse... (More)
The genomic region containing the genes encoding the first leukotriene B(4) receptor, BLTR, as well as the recently cloned second leukotriene B(4)-activated receptor, BLTR2, was mapped by (a) sequence analysis of a human bacterial artificial chromosome (BAC) library containing a 15-kb segment corresponding to chromosome 14q11. 2-12 where the BLTR/BLTR2 genes were previously shown to be located, together with (b) sequence analysis of 83 expressed sequence tags (ESTs) from this region. The BLTR gene includes four different 5' untranslated regions (UTRs) and a mutual acceptor site for the exon containing the intronless open reading frame. The BLTR2 gene is intronless and overlapped by a 5' UTR splice version of BLTR and, on the reverse strand, of the apoptosis-related CIDE-B gene. This indicates a complex posttranscriptional gene regulation. Further adding to the complexity of the region is evidence of a fourth putative and novel gene, most homologous to the rat adenylyl cyclase IV gene. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical and Biophysical Research Communications
volume
274
issue
2
pages
383 - 388
publisher
Elsevier
external identifiers
  • pmid:10913347
  • scopus:0034596256
ISSN
1090-2104
DOI
10.1006/bbrc.2000.3153
language
English
LU publication?
yes
id
abf5bb4a-1665-4ce2-a7fb-51d5cfc35f68 (old id 1117807)
date added to LUP
2008-06-25 08:31:40
date last changed
2017-01-01 07:14:26
@article{abf5bb4a-1665-4ce2-a7fb-51d5cfc35f68,
  abstract     = {The genomic region containing the genes encoding the first leukotriene B(4) receptor, BLTR, as well as the recently cloned second leukotriene B(4)-activated receptor, BLTR2, was mapped by (a) sequence analysis of a human bacterial artificial chromosome (BAC) library containing a 15-kb segment corresponding to chromosome 14q11. 2-12 where the BLTR/BLTR2 genes were previously shown to be located, together with (b) sequence analysis of 83 expressed sequence tags (ESTs) from this region. The BLTR gene includes four different 5' untranslated regions (UTRs) and a mutual acceptor site for the exon containing the intronless open reading frame. The BLTR2 gene is intronless and overlapped by a 5' UTR splice version of BLTR and, on the reverse strand, of the apoptosis-related CIDE-B gene. This indicates a complex posttranscriptional gene regulation. Further adding to the complexity of the region is evidence of a fourth putative and novel gene, most homologous to the rat adenylyl cyclase IV gene.},
  author       = {Nilsson, Niclas and Tryselius, Ylva and Owman, Christer},
  issn         = {1090-2104},
  language     = {eng},
  number       = {2},
  pages        = {383--388},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14},
  url          = {http://dx.doi.org/10.1006/bbrc.2000.3153},
  volume       = {274},
  year         = {2000},
}