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Interferon-alpha and ribavirin treatment of hepatitis C in children with malignancy in remission

Christensson, Bertil LU ; Wiebe, Thomas LU ; Akesson, Ann and Widell, Anders LU (2000) In Clinical Infectious Diseases 30(3). p.585-586
Abstract
Twenty-eight cases of hepatitis C virus (HCV) infection were identified in children in a pediatric oncology ward during 2 nosocomial outbreaks. HCV infection spontaneously cleared in 6 patients (21%). Eleven patients with persistent HCV viremia who had malignant diseases in remission after treatment were given a 48-week course of combined therapy with interferon-alpha (5x106 U 3 times weekly) and oral ribavirin (15 mg/kg/d). Seven (64%) of the 11 patients had sustained virological responses 6 and 12 months after cessation of therapy. Side effects were common but generally were mild or moderate.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Infectious Diseases
volume
30
issue
3
pages
585 - 586
publisher
The Infectious Diseases Society of America
external identifiers
  • pmid:10722449
  • scopus:0034035431
ISSN
1537-6591
DOI
10.1086/313709
language
English
LU publication?
yes
id
d0feb989-5115-4ee1-8e81-784762b8a12e (old id 1117827)
date added to LUP
2008-06-25 08:53:04
date last changed
2017-05-14 03:32:50
@article{d0feb989-5115-4ee1-8e81-784762b8a12e,
  abstract     = {Twenty-eight cases of hepatitis C virus (HCV) infection were identified in children in a pediatric oncology ward during 2 nosocomial outbreaks. HCV infection spontaneously cleared in 6 patients (21%). Eleven patients with persistent HCV viremia who had malignant diseases in remission after treatment were given a 48-week course of combined therapy with interferon-alpha (5x106 U 3 times weekly) and oral ribavirin (15 mg/kg/d). Seven (64%) of the 11 patients had sustained virological responses 6 and 12 months after cessation of therapy. Side effects were common but generally were mild or moderate.},
  author       = {Christensson, Bertil and Wiebe, Thomas and Akesson, Ann and Widell, Anders},
  issn         = {1537-6591},
  language     = {eng},
  number       = {3},
  pages        = {585--586},
  publisher    = {The Infectious Diseases Society of America},
  series       = {Clinical Infectious Diseases},
  title        = {Interferon-alpha and ribavirin treatment of hepatitis C in children with malignancy in remission},
  url          = {http://dx.doi.org/10.1086/313709},
  volume       = {30},
  year         = {2000},
}