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Effects of a vasopressin antagonist in women with dysmenorrhea

Valentin, Lil LU ; Sladkevicius, Povilas LU ; Kindahl, H.; Broeders, A.; Marsal, Karel LU and Melin, P. (2000) In Gynecologic and Obstetric Investigation 50(3). p.170-177
Abstract
We compared menstrual pain, uterine contractility and blood circulation, and plasma concentrations of vasopressin and prostaglandin F(2alpha) metabolite in women with versus without primary dysmenorrhea, and determined the effects of a vasopressin antagonist, 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-oxytocin (Atosiban), on these parameters. Our results do not support the contention that vasopressin is involved in the etiology of dysmenorrhea, plasma concentrations of vasopressin being similar in dysmenorrheic women and controls, and the vasopressin antagonist Atosiban having no effect on menstrual pain, intrauterine pressure or uterine artery pulsatility index in dysmenorrheic women.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Gynecologic and Obstetric Investigation
volume
50
issue
3
pages
170 - 177
publisher
Karger
external identifiers
  • scopus:0033803386
ISSN
1423-002X
DOI
10.1159/000010319
language
English
LU publication?
yes
id
09df03e5-43a1-4d3e-895f-64a0c60ea48a (old id 1117924)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11014949
date added to LUP
2008-06-24 15:11:18
date last changed
2017-01-01 05:17:11
@article{09df03e5-43a1-4d3e-895f-64a0c60ea48a,
  abstract     = {We compared menstrual pain, uterine contractility and blood circulation, and plasma concentrations of vasopressin and prostaglandin F(2alpha) metabolite in women with versus without primary dysmenorrhea, and determined the effects of a vasopressin antagonist, 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-oxytocin (Atosiban), on these parameters. Our results do not support the contention that vasopressin is involved in the etiology of dysmenorrhea, plasma concentrations of vasopressin being similar in dysmenorrheic women and controls, and the vasopressin antagonist Atosiban having no effect on menstrual pain, intrauterine pressure or uterine artery pulsatility index in dysmenorrheic women.},
  author       = {Valentin, Lil and Sladkevicius, Povilas and Kindahl, H. and Broeders, A. and Marsal, Karel and Melin, P.},
  issn         = {1423-002X},
  language     = {eng},
  number       = {3},
  pages        = {170--177},
  publisher    = {Karger},
  series       = {Gynecologic and Obstetric Investigation},
  title        = {Effects of a vasopressin antagonist in women with dysmenorrhea},
  url          = {http://dx.doi.org/10.1159/000010319},
  volume       = {50},
  year         = {2000},
}