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The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke

Carlsson, Martin; Orho-Melander, Marju LU ; Hedenbro, Jan LU ; Almgren, Peter LU and Groop, Leif LU (2000) In Journal of Clinical Endocrinology and Metabolism 85(8). p.2801-2804
Abstract
To test the hypothesis that the A/T polymorphism of the fatty acid-binding protein 2 gene (FABP2) is associated with impaired lipid metabolism and cardiovascular disease, we compared clinical characteristics and a parental history of cardiovascular disease between 213 sibling pairs discordant for the polymorphism. Siblings with an excess of the T54 allele had higher triglyceride (P = 0.002) and cholesterol (P = 0.019) concentrations than siblings with the A54 allele. Parents of offspring with the T54T and T54A genotypes reported an increased prevalence of stroke compared to parents of offspring with the A54A genotype (P = 0.007). In summary, we have confirmed the association of the FABP2 T54 allele with increased concentrations of... (More)
To test the hypothesis that the A/T polymorphism of the fatty acid-binding protein 2 gene (FABP2) is associated with impaired lipid metabolism and cardiovascular disease, we compared clinical characteristics and a parental history of cardiovascular disease between 213 sibling pairs discordant for the polymorphism. Siblings with an excess of the T54 allele had higher triglyceride (P = 0.002) and cholesterol (P = 0.019) concentrations than siblings with the A54 allele. Parents of offspring with the T54T and T54A genotypes reported an increased prevalence of stroke compared to parents of offspring with the A54A genotype (P = 0.007). In summary, we have confirmed the association of the FABP2 T54 allele with increased concentrations of cholesterol and triglycerides in genotype-discordant sibling pairs. We also present novel evidence that genetic variation in the FABP2 gene may increase susceptibility to stroke. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
85
issue
8
pages
2801 - 2804
publisher
The Endocrine Society
external identifiers
  • pmid:10946885
  • scopus:0034457056
ISSN
1945-7197
language
English
LU publication?
yes
id
e8e4ce49-d05d-433e-a0a8-49c19ea2f53d (old id 1118063)
alternative location
http://jcem.endojournals.org/cgi/content/abstract/85/8/2801
date added to LUP
2008-06-24 14:04:20
date last changed
2017-01-01 06:46:52
@article{e8e4ce49-d05d-433e-a0a8-49c19ea2f53d,
  abstract     = {To test the hypothesis that the A/T polymorphism of the fatty acid-binding protein 2 gene (FABP2) is associated with impaired lipid metabolism and cardiovascular disease, we compared clinical characteristics and a parental history of cardiovascular disease between 213 sibling pairs discordant for the polymorphism. Siblings with an excess of the T54 allele had higher triglyceride (P = 0.002) and cholesterol (P = 0.019) concentrations than siblings with the A54 allele. Parents of offspring with the T54T and T54A genotypes reported an increased prevalence of stroke compared to parents of offspring with the A54A genotype (P = 0.007). In summary, we have confirmed the association of the FABP2 T54 allele with increased concentrations of cholesterol and triglycerides in genotype-discordant sibling pairs. We also present novel evidence that genetic variation in the FABP2 gene may increase susceptibility to stroke.},
  author       = {Carlsson, Martin and Orho-Melander, Marju and Hedenbro, Jan and Almgren, Peter and Groop, Leif},
  issn         = {1945-7197},
  language     = {eng},
  number       = {8},
  pages        = {2801--2804},
  publisher    = {The Endocrine Society},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke},
  volume       = {85},
  year         = {2000},
}