EGF infusion stimulates the proliferation and migration of embryonic progenitor cells transplanted in the adult rat striatum
Fricker-Gates, R A ; Winkler, Christian LU ; Kirik, Deniz LU ; Rosenblad, C ; Carpenter, M K and Björklund, Anders LU
(2000)
In Experimental Neurology
165(2).
p.237-247
- Abstract
- Immature progenitor cells (generated by in vitro propagation) may provide a useful alternative to primary cells (from dissected embryonic tissue) for transplantation if their migratory and proliferative and differentiation properties can be controlled and directed in vivo. In this study E15 murine EGF-responsive progenitor cells were transplanted to the striatum of adult rats. Simultaneously, these animals received continuous infusion of either epidermal growth factor (EGF) or vehicle, to the lateral ventricle, for 8 days. In animals that received EGF, the transplanted progenitors migrated toward the lateral ventricle and proliferated, as evidenced by bromodeoxyuridine incorporation. Progenitor cells transplanted to rats that received... (More)
- Immature progenitor cells (generated by in vitro propagation) may provide a useful alternative to primary cells (from dissected embryonic tissue) for transplantation if their migratory and proliferative and differentiation properties can be controlled and directed in vivo. In this study E15 murine EGF-responsive progenitor cells were transplanted to the striatum of adult rats. Simultaneously, these animals received continuous infusion of either epidermal growth factor (EGF) or vehicle, to the lateral ventricle, for 8 days. In animals that received EGF, the transplanted progenitors migrated toward the lateral ventricle and proliferated, as evidenced by bromodeoxyuridine incorporation. Progenitor cells transplanted to rats that received vehicle infusions showed neither of these responses. In all animals, transplanted progenitors expressed an immature astrocyte or oligodendrocyte phenotype, the majority of cells being astrocytes. We conclude that EGF stimulates the migration and proliferation of murine progenitor cells in vivo, either directly or indirectly, but does not influence their phenotypic differentiation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1118210
- author
- Fricker-Gates, R A
; Winkler, Christian
LU
; Kirik, Deniz
LU
; Rosenblad, C
; Carpenter, M K
and Björklund, Anders
LU
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Experimental Neurology
- volume
- 165
- issue
- 2
- pages
- 237 - 247
- publisher
- Elsevier
- external identifiers
-
- pmid:10993684
- scopus:0033803201
- pmid:10993684
- ISSN
- 0014-4886
- DOI
- 10.1006/exnr.2000.7482
- language
- English
- LU publication?
- yes
- id
- 4a48ab7e-de20-4dda-81f7-40ce621b1932 (old id 1118210)
- date added to LUP
- 2016-04-01 11:44:27
- date last changed
- 2022-01-26 17:34:20
@article{4a48ab7e-de20-4dda-81f7-40ce621b1932,
abstract = {{Immature progenitor cells (generated by in vitro propagation) may provide a useful alternative to primary cells (from dissected embryonic tissue) for transplantation if their migratory and proliferative and differentiation properties can be controlled and directed in vivo. In this study E15 murine EGF-responsive progenitor cells were transplanted to the striatum of adult rats. Simultaneously, these animals received continuous infusion of either epidermal growth factor (EGF) or vehicle, to the lateral ventricle, for 8 days. In animals that received EGF, the transplanted progenitors migrated toward the lateral ventricle and proliferated, as evidenced by bromodeoxyuridine incorporation. Progenitor cells transplanted to rats that received vehicle infusions showed neither of these responses. In all animals, transplanted progenitors expressed an immature astrocyte or oligodendrocyte phenotype, the majority of cells being astrocytes. We conclude that EGF stimulates the migration and proliferation of murine progenitor cells in vivo, either directly or indirectly, but does not influence their phenotypic differentiation.}},
author = {{Fricker-Gates, R A and Winkler, Christian and Kirik, Deniz and Rosenblad, C and Carpenter, M K and Björklund, Anders}},
issn = {{0014-4886}},
language = {{eng}},
number = {{2}},
pages = {{237--247}},
publisher = {{Elsevier}},
series = {{Experimental Neurology}},
title = {{EGF infusion stimulates the proliferation and migration of embryonic progenitor cells transplanted in the adult rat striatum}},
url = {{http://dx.doi.org/10.1006/exnr.2000.7482}},
doi = {{10.1006/exnr.2000.7482}},
volume = {{165}},
year = {{2000}},
}