Advanced

Cytogenetic findings and clinical course in a consecutive series of Wilms tumors

Kullendorff, Carl Magnus LU ; Soller, Maria LU ; Wiebe, Thomas LU and Mertens, Fredrik LU (2003) In Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00 140(1). p.82-87
Abstract

Wilms tumor (WT) is characterized by a nonrandom pattern of chromosome aberrations, but the clinical significance of different cytogenetic patterns is unknown. The present study describes the cytogenetic findings and the clinical course in a cohort of 39 children with WT. Samples for short-term culturing and cytogenetic analysis were obtained during a 15-year period. Clonal chromosome aberrations were detected in 23 samples from 19 patients. Tumors that relapsed more often showed clonal aberrations than did tumors that did not. However, this association my have been due to sampling bias. Among the cases with karyotypically abnormal samples, the modal chromosome number was in the near-diploid range in 10, hyperdiploid/hypotriploid in 8,... (More)

Wilms tumor (WT) is characterized by a nonrandom pattern of chromosome aberrations, but the clinical significance of different cytogenetic patterns is unknown. The present study describes the cytogenetic findings and the clinical course in a cohort of 39 children with WT. Samples for short-term culturing and cytogenetic analysis were obtained during a 15-year period. Clonal chromosome aberrations were detected in 23 samples from 19 patients. Tumors that relapsed more often showed clonal aberrations than did tumors that did not. However, this association my have been due to sampling bias. Among the cases with karyotypically abnormal samples, the modal chromosome number was in the near-diploid range in 10, hyperdiploid/hypotriploid in 8, and hypodiploid in 1. The most common changes were trisomy 12 and gain of 1q material (8 cases each), trisomy/tetrasomy 8 (7 cases), and trisomy 13 (5 cases). None of these frequently occurring abnormalities, or the ploidy level, showed any association with clinical outcome, using tumor relapse as an end-point. Nor could any relationship between cytogenetic features and histopathologic subtype be discerned. Although the number of informative cases was too small for proper evaluation, the present study did not contradict the previous notion that loss of material from the long arm of chromosome 16 is associated with poor clinical outcome. All three patients with deletion of 16q developed metastases.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Aneuploidy, Child, Child, Preschool, Chromosome Aberrations, Chromosomes, Human, Cohort Studies, Disease Progression, Female, Humans, Infant, Karyotyping, Kidney Neoplasms, Male, Sweden, Trisomy, Tumor Cells, Cultured, Wilms Tumor, Journal Article, Research Support, Non-U.S. Gov't
in
Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00
volume
140
issue
1
pages
6 pages
publisher
Elsevier
external identifiers
  • wos:000180401900016
  • pmid:12550766
  • scopus:0037242770
ISSN
0165-4608
DOI
10.1016/S0165-4608(02)00635-0
language
English
LU publication?
yes
id
0501c057-9726-4bd3-b138-0e668281513e (old id 111840)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12550766&dopt=Abstract
date added to LUP
2007-07-19 12:21:42
date last changed
2017-04-09 04:21:20
@article{0501c057-9726-4bd3-b138-0e668281513e,
  abstract     = {<p>Wilms tumor (WT) is characterized by a nonrandom pattern of chromosome aberrations, but the clinical significance of different cytogenetic patterns is unknown. The present study describes the cytogenetic findings and the clinical course in a cohort of 39 children with WT. Samples for short-term culturing and cytogenetic analysis were obtained during a 15-year period. Clonal chromosome aberrations were detected in 23 samples from 19 patients. Tumors that relapsed more often showed clonal aberrations than did tumors that did not. However, this association my have been due to sampling bias. Among the cases with karyotypically abnormal samples, the modal chromosome number was in the near-diploid range in 10, hyperdiploid/hypotriploid in 8, and hypodiploid in 1. The most common changes were trisomy 12 and gain of 1q material (8 cases each), trisomy/tetrasomy 8 (7 cases), and trisomy 13 (5 cases). None of these frequently occurring abnormalities, or the ploidy level, showed any association with clinical outcome, using tumor relapse as an end-point. Nor could any relationship between cytogenetic features and histopathologic subtype be discerned. Although the number of informative cases was too small for proper evaluation, the present study did not contradict the previous notion that loss of material from the long arm of chromosome 16 is associated with poor clinical outcome. All three patients with deletion of 16q developed metastases.</p>},
  author       = {Kullendorff, Carl Magnus and Soller, Maria and Wiebe, Thomas and Mertens, Fredrik},
  issn         = {0165-4608},
  keyword      = {Adolescent,Aneuploidy,Child,Child, Preschool,Chromosome Aberrations,Chromosomes, Human,Cohort Studies,Disease Progression,Female,Humans,Infant,Karyotyping,Kidney Neoplasms,Male,Sweden,Trisomy,Tumor Cells, Cultured,Wilms Tumor,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {82--87},
  publisher    = {Elsevier},
  series       = {Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00},
  title        = {Cytogenetic findings and clinical course in a consecutive series of Wilms tumors},
  url          = {http://dx.doi.org/10.1016/S0165-4608(02)00635-0},
  volume       = {140},
  year         = {2003},
}