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Residual mass in aggressive lymphoma--does size, measured by computed tomography, influence clinical outcome?

Rodriguez-Catarino, M; Jerkeman, Mats LU ; Ahlstrom, H; Glimelius, B and Hagberg, H (2000) In Acta Oncologica 39(4). p.485-489
Abstract
Residual masses are frequently found in patients with aggressive lymphomas, following therapy. A study was undertaken to determine whether initial tumour size, changes during treatment, or size of the residual mass could provide prognostic information. Computed tomography (CT) examinations were carried out before, midway and after completion of chemotherapy in 37 patients with aggressive lymphoma with residual mass after treatment. The tumours were measured for both the greatest diameter sizes and area. The size of the residual mass correlated with the tumour size at diagnosis. Neither a large tumour size before treatment nor a large residual mass after treatment correlated with an increase in rate of relapse. The initial tumour reduction... (More)
Residual masses are frequently found in patients with aggressive lymphomas, following therapy. A study was undertaken to determine whether initial tumour size, changes during treatment, or size of the residual mass could provide prognostic information. Computed tomography (CT) examinations were carried out before, midway and after completion of chemotherapy in 37 patients with aggressive lymphoma with residual mass after treatment. The tumours were measured for both the greatest diameter sizes and area. The size of the residual mass correlated with the tumour size at diagnosis. Neither a large tumour size before treatment nor a large residual mass after treatment correlated with an increase in rate of relapse. The initial tumour reduction (measured after completion of half of the planned chemotherapy) was less pronounced in relapsing patients compared to relapse-free patients. Using a cut-off level of 70% tumour reduction (measured after completion of half of the planned chemotherapy), 66% of patients with a tumour reduction of < 70% relapsed, compared with 22% (p < 0.05) in those with more marked tumour regression. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
39
issue
4
pages
485 - 489
publisher
Taylor & Francis
external identifiers
  • pmid:11041110
  • scopus:0033799606
ISSN
1651-226X
DOI
10.1080/028418600750013393
language
English
LU publication?
no
id
cb5ae9e4-241c-42d2-92a3-6de21333a4d6 (old id 1118401)
date added to LUP
2008-06-16 14:47:10
date last changed
2017-01-01 06:52:17
@article{cb5ae9e4-241c-42d2-92a3-6de21333a4d6,
  abstract     = {Residual masses are frequently found in patients with aggressive lymphomas, following therapy. A study was undertaken to determine whether initial tumour size, changes during treatment, or size of the residual mass could provide prognostic information. Computed tomography (CT) examinations were carried out before, midway and after completion of chemotherapy in 37 patients with aggressive lymphoma with residual mass after treatment. The tumours were measured for both the greatest diameter sizes and area. The size of the residual mass correlated with the tumour size at diagnosis. Neither a large tumour size before treatment nor a large residual mass after treatment correlated with an increase in rate of relapse. The initial tumour reduction (measured after completion of half of the planned chemotherapy) was less pronounced in relapsing patients compared to relapse-free patients. Using a cut-off level of 70% tumour reduction (measured after completion of half of the planned chemotherapy), 66% of patients with a tumour reduction of &lt; 70% relapsed, compared with 22% (p &lt; 0.05) in those with more marked tumour regression.},
  author       = {Rodriguez-Catarino, M and Jerkeman, Mats and Ahlstrom, H and Glimelius, B and Hagberg, H},
  issn         = {1651-226X},
  language     = {eng},
  number       = {4},
  pages        = {485--489},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Residual mass in aggressive lymphoma--does size, measured by computed tomography, influence clinical outcome?},
  url          = {http://dx.doi.org/10.1080/028418600750013393},
  volume       = {39},
  year         = {2000},
}