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Serum IgE reactivity to Malassezia furfur extract and recombinant M-furfur allergens in patients with atopic dermatitis

Zargari, A.; Eshaghi, H.; Bäck, Ove LU ; Johansson, S. and Scheynius, A. (2001) In Acta Dermato-Venereologica 81(6). p.418-422
Abstract
IgE reactivity to the opportunistic yeast Malassezia furfur can be found in patients with atopic dermatitis (AD). We have previously cloned and expressed 6 recombinant allergens (rMal f 1. rMal f 5-9) from M. furfur. In the present study, we used ImmunoCAP to investigate whether these rMal f allergens can be useful in the diagnosis of M. furfur-associated AD compared with the M. furfur extract. A total of 156 adult patients with a clinical diagnosis of AD participated in the study. Sixty-four percent had increased total serum IgE levels, 79% had specific IgE antibodies to common inhalant allergens and 47% had IgE antibodies to M. furfur extract. IgE antibodies to any of the rMal f allergens were detected among 86 (55%) of the patients, 14... (More)
IgE reactivity to the opportunistic yeast Malassezia furfur can be found in patients with atopic dermatitis (AD). We have previously cloned and expressed 6 recombinant allergens (rMal f 1. rMal f 5-9) from M. furfur. In the present study, we used ImmunoCAP to investigate whether these rMal f allergens can be useful in the diagnosis of M. furfur-associated AD compared with the M. furfur extract. A total of 156 adult patients with a clinical diagnosis of AD participated in the study. Sixty-four percent had increased total serum IgE levels, 79% had specific IgE antibodies to common inhalant allergens and 47% had IgE antibodies to M. furfur extract. IgE antibodies to any of the rMal f allergens were detected among 86 (55%) of the patients, 14 (16%) of whom did not react to the M. furfur extract. Any individual rMal f allergen detected between 32% and 89% of the patients ImmunoCAP-positive to the M. fin fur extract, with the highest sensitivity for rMal f 9. Therefore, a couple of individual rMal f allergens can improve the diagnosis of M. furfur-associated I-E allergies in patients with AD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Dermato-Venereologica
volume
81
issue
6
pages
418 - 422
publisher
Medical Journals Limited
external identifiers
  • wos:000173698500009
  • scopus:0035699353
ISSN
1651-2057
DOI
10.1080/000155501317208363
language
English
LU publication?
yes
id
46b66748-f96e-49df-9ed3-b5c6e7792753 (old id 1118473)
date added to LUP
2008-07-18 16:25:46
date last changed
2018-07-22 04:02:52
@article{46b66748-f96e-49df-9ed3-b5c6e7792753,
  abstract     = {IgE reactivity to the opportunistic yeast Malassezia furfur can be found in patients with atopic dermatitis (AD). We have previously cloned and expressed 6 recombinant allergens (rMal f 1. rMal f 5-9) from M. furfur. In the present study, we used ImmunoCAP to investigate whether these rMal f allergens can be useful in the diagnosis of M. furfur-associated AD compared with the M. furfur extract. A total of 156 adult patients with a clinical diagnosis of AD participated in the study. Sixty-four percent had increased total serum IgE levels, 79% had specific IgE antibodies to common inhalant allergens and 47% had IgE antibodies to M. furfur extract. IgE antibodies to any of the rMal f allergens were detected among 86 (55%) of the patients, 14 (16%) of whom did not react to the M. furfur extract. Any individual rMal f allergen detected between 32% and 89% of the patients ImmunoCAP-positive to the M. fin fur extract, with the highest sensitivity for rMal f 9. Therefore, a couple of individual rMal f allergens can improve the diagnosis of M. furfur-associated I-E allergies in patients with AD.},
  author       = {Zargari, A. and Eshaghi, H. and Bäck, Ove and Johansson, S. and Scheynius, A.},
  issn         = {1651-2057},
  language     = {eng},
  number       = {6},
  pages        = {418--422},
  publisher    = {Medical Journals Limited},
  series       = {Acta Dermato-Venereologica},
  title        = {Serum IgE reactivity to Malassezia furfur extract and recombinant M-furfur allergens in patients with atopic dermatitis},
  url          = {http://dx.doi.org/10.1080/000155501317208363},
  volume       = {81},
  year         = {2001},
}