Advanced

Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins - An idea whose time for testing is coming, Part II

Shah, Prediman K.; Kaul, Sanjay; Nilsson, Jan LU and Cercek, Bojan (2001) In Circulation 104(20). p.2498-2502
Abstract
Despite the benefits of currently available preventative and therapeutic interventions, atherosclerotic vascular disease continues to be a major cause of morbidity and mortality in much of the Western World. This emphasize,,, the need for additional preventive and therapeutic interventions exploiting new targets to compliment and augment the results of LDL lowering and other current strategies. One such potential target is HDL and its apolipoproteins, A large body of experimental evidence suggests that augmenting the levels and/or function of HDL and its apolipoproteins can have major vascular protective effects ranging from prevention to stabilization and regression, independent of total or non-HDL cholesterol levels. Therefore, we think... (More)
Despite the benefits of currently available preventative and therapeutic interventions, atherosclerotic vascular disease continues to be a major cause of morbidity and mortality in much of the Western World. This emphasize,,, the need for additional preventive and therapeutic interventions exploiting new targets to compliment and augment the results of LDL lowering and other current strategies. One such potential target is HDL and its apolipoproteins, A large body of experimental evidence suggests that augmenting the levels and/or function of HDL and its apolipoproteins can have major vascular protective effects ranging from prevention to stabilization and regression, independent of total or non-HDL cholesterol levels. Therefore, we think that the time is ripe for the development and clinical testing of this new frontier in antiatherogenic strategy. In the present article, We will review the structure/function of HDL and explore means of enhancing the levels and/or function of HDL and its apolipoproteins for vascular protection. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
apolipoproteins, lipoproteins, atherosclerosis
in
Circulation
volume
104
issue
20
pages
2498 - 2502
publisher
Lippincott Williams and Wilkins
external identifiers
  • wos:000172260600030
  • scopus:0035856555
ISSN
1524-4539
DOI
10.1161/hc4501.098468
language
English
LU publication?
yes
id
c6101adf-a317-4387-b76d-64c26baf0dc5 (old id 1118666)
date added to LUP
2008-07-14 11:20:09
date last changed
2018-01-28 04:08:40
@article{c6101adf-a317-4387-b76d-64c26baf0dc5,
  abstract     = {Despite the benefits of currently available preventative and therapeutic interventions, atherosclerotic vascular disease continues to be a major cause of morbidity and mortality in much of the Western World. This emphasize,,, the need for additional preventive and therapeutic interventions exploiting new targets to compliment and augment the results of LDL lowering and other current strategies. One such potential target is HDL and its apolipoproteins, A large body of experimental evidence suggests that augmenting the levels and/or function of HDL and its apolipoproteins can have major vascular protective effects ranging from prevention to stabilization and regression, independent of total or non-HDL cholesterol levels. Therefore, we think that the time is ripe for the development and clinical testing of this new frontier in antiatherogenic strategy. In the present article, We will review the structure/function of HDL and explore means of enhancing the levels and/or function of HDL and its apolipoproteins for vascular protection.},
  author       = {Shah, Prediman K. and Kaul, Sanjay and Nilsson, Jan and Cercek, Bojan},
  issn         = {1524-4539},
  keyword      = {apolipoproteins,lipoproteins,atherosclerosis},
  language     = {eng},
  number       = {20},
  pages        = {2498--2502},
  publisher    = {Lippincott Williams and Wilkins},
  series       = {Circulation},
  title        = {Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins - An idea whose time for testing is coming, Part II},
  url          = {http://dx.doi.org/10.1161/hc4501.098468},
  volume       = {104},
  year         = {2001},
}