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Global repolarization sequence of the ventricular endocardium: Monophasic action potential mapping in swine and humans

Yuan, Shiwen LU ; Kongstad Rasmussen, Ole LU ; Hertervig, Eva LU ; Holm, Magnus; Grins, Edgar and Olsson, Bertil LU (2001) In PACE 24(10). p.1479-1488
Abstract
The aim of this study was to evaluate the global sequence of repolarization over the ventricular endocardium. Disturbances in myocardial repolarization are associated with the genesis of arrhythmias. However, little is known about the global sequence of repolarization. Monophasic action potentials (MAPs) were recorded from 61 +/- 18 LV and/or RV sites in ten healthy pigs and from 43 +/- 15 LV or RV sites in eight patients using the CARTO system. Local activation time (AT), end-of-repolarization (EOR) time, and MAP duration were calculated and three-dimensional global maps of AT, EOR, and MAP duration constructed. LV maps were obtained from all ten pigs and RV maps from three pigs. Five RV maps and five LV maps were obtained from the eight... (More)
The aim of this study was to evaluate the global sequence of repolarization over the ventricular endocardium. Disturbances in myocardial repolarization are associated with the genesis of arrhythmias. However, little is known about the global sequence of repolarization. Monophasic action potentials (MAPs) were recorded from 61 +/- 18 LV and/or RV sites in ten healthy pigs and from 43 +/- 15 LV or RV sites in eight patients using the CARTO system. Local activation time (AT), end-of-repolarization (EOR) time, and MAP duration were calculated and three-dimensional global maps of AT, EOR, and MAP duration constructed. LV maps were obtained from all ten pigs and RV maps from three pigs. Five RV maps and five LV maps were obtained from the eight patients. (1) EOR sequence was recognizable in 12 of 13 pig maps and in all the patient maps. (2) EOR followed the sequence of activation in 12 of 13 pig maps and 8 of 10 patient maps. (3) The longest MAPs were recorded in or near the earliest activation area, and the shortest ones in or near the latest activation area in all the pig maps and in nine of ten and eight of ten patient maps, respectively. (4) In all maps, MAP duration and AT were negatively correlated, and EOR and AT positively correlated. In conclusion, repolarization gradients exist over the pig and the human ventricular endocardium. The activation sequence is a determinant for the repolarization sequence. The magnitude of the progressive MAP shortening with progressively later activation, relative to local AT, is a critical factor governing the direction and pattern of the EOR. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
monophasic action potential, mapping, repolarization, activation sequence
in
PACE
volume
24
issue
10
pages
1479 - 1488
publisher
Wiley-Blackwell
external identifiers
  • wos:000171700700005
  • scopus:0034780539
ISSN
1540-8159
DOI
10.1046/j.1460-9592.2001.01479.x
language
English
LU publication?
yes
id
7e610d55-829c-4f17-81fd-9a3619534164 (old id 1118768)
date added to LUP
2008-07-18 16:13:02
date last changed
2018-01-07 08:33:11
@article{7e610d55-829c-4f17-81fd-9a3619534164,
  abstract     = {The aim of this study was to evaluate the global sequence of repolarization over the ventricular endocardium. Disturbances in myocardial repolarization are associated with the genesis of arrhythmias. However, little is known about the global sequence of repolarization. Monophasic action potentials (MAPs) were recorded from 61 +/- 18 LV and/or RV sites in ten healthy pigs and from 43 +/- 15 LV or RV sites in eight patients using the CARTO system. Local activation time (AT), end-of-repolarization (EOR) time, and MAP duration were calculated and three-dimensional global maps of AT, EOR, and MAP duration constructed. LV maps were obtained from all ten pigs and RV maps from three pigs. Five RV maps and five LV maps were obtained from the eight patients. (1) EOR sequence was recognizable in 12 of 13 pig maps and in all the patient maps. (2) EOR followed the sequence of activation in 12 of 13 pig maps and 8 of 10 patient maps. (3) The longest MAPs were recorded in or near the earliest activation area, and the shortest ones in or near the latest activation area in all the pig maps and in nine of ten and eight of ten patient maps, respectively. (4) In all maps, MAP duration and AT were negatively correlated, and EOR and AT positively correlated. In conclusion, repolarization gradients exist over the pig and the human ventricular endocardium. The activation sequence is a determinant for the repolarization sequence. The magnitude of the progressive MAP shortening with progressively later activation, relative to local AT, is a critical factor governing the direction and pattern of the EOR.},
  author       = {Yuan, Shiwen and Kongstad Rasmussen, Ole and Hertervig, Eva and Holm, Magnus and Grins, Edgar and Olsson, Bertil},
  issn         = {1540-8159},
  keyword      = {monophasic action potential,mapping,repolarization,activation sequence},
  language     = {eng},
  number       = {10},
  pages        = {1479--1488},
  publisher    = {Wiley-Blackwell},
  series       = {PACE},
  title        = {Global repolarization sequence of the ventricular endocardium: Monophasic action potential mapping in swine and humans},
  url          = {http://dx.doi.org/10.1046/j.1460-9592.2001.01479.x},
  volume       = {24},
  year         = {2001},
}