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Arrhythmia as a result of poor intercellular coupling in the sinus node: A simulation study

Östborn, Per LU ; Wohlfart, Björn LU and Ohlén, Gunnar LU (2001) In Journal of Theoretical Biology 211(3). p.201-217
Abstract
The effects of reduced intercellular coupling in the sinus node were investigated by means of simulations. Coupling was reduced both uniformly, and by introducing localized interaction blocks. In either case, model sinus node element networks typically splitted into frequency domains. These were defined as groups of neighbour elements which all attained the same mean firing frequency. In systems, simulating the vicinity of an impulse outlet to the atrium, the sinus node elements often splitted into two domains, one slowly firing just inside the outlet, and one normally firing large domain in the sinus node interior. This two-domain situation was analysed using a two-element system. Wenckebach conduction and advanced (m:1) exit blocks were... (More)
The effects of reduced intercellular coupling in the sinus node were investigated by means of simulations. Coupling was reduced both uniformly, and by introducing localized interaction blocks. In either case, model sinus node element networks typically splitted into frequency domains. These were defined as groups of neighbour elements which all attained the same mean firing frequency. In systems, simulating the vicinity of an impulse outlet to the atrium, the sinus node elements often splitted into two domains, one slowly firing just inside the outlet, and one normally firing large domain in the sinus node interior. This two-domain situation was analysed using a two-element system. Wenckebach conduction and advanced (m:1) exit blocks were seen, together with more odd block patterns and slow chaotic rhythms. The two-domain situation appeared also when two discrete outlets were considered. The slow domains around each outlet synchronized via the atrium. However, if there were some degree of exit block through one of the outlets only, brady-tachy like rhythms could be simulated due to a re-entrant circuit including both sinus node and atrial tissue. In conclusion, poor coupling in the sinus node seems to be sufficient to produce most arrhythmias in the sick sinus syndrome. (Less)
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type
Contribution to journal
publication status
published
subject
in
Journal of Theoretical Biology
volume
211
issue
3
pages
201 - 217
publisher
Academic Press
external identifiers
  • wos:000169984000002
  • scopus:0035822714
ISSN
1095-8541
DOI
10.1006/jtbi.2001.2339
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Clinical Physiology (Lund) (013013000), Mathematical Physics (Faculty of Technology) (011040002), Classical archaeology and ancient history (015004001)
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6bc7bce9-ee92-4ddd-9511-cc56bfb2ab4a (old id 1119076)
date added to LUP
2016-04-01 17:06:11
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2020-12-08 04:47:26
@article{6bc7bce9-ee92-4ddd-9511-cc56bfb2ab4a,
  abstract     = {The effects of reduced intercellular coupling in the sinus node were investigated by means of simulations. Coupling was reduced both uniformly, and by introducing localized interaction blocks. In either case, model sinus node element networks typically splitted into frequency domains. These were defined as groups of neighbour elements which all attained the same mean firing frequency. In systems, simulating the vicinity of an impulse outlet to the atrium, the sinus node elements often splitted into two domains, one slowly firing just inside the outlet, and one normally firing large domain in the sinus node interior. This two-domain situation was analysed using a two-element system. Wenckebach conduction and advanced (m:1) exit blocks were seen, together with more odd block patterns and slow chaotic rhythms. The two-domain situation appeared also when two discrete outlets were considered. The slow domains around each outlet synchronized via the atrium. However, if there were some degree of exit block through one of the outlets only, brady-tachy like rhythms could be simulated due to a re-entrant circuit including both sinus node and atrial tissue. In conclusion, poor coupling in the sinus node seems to be sufficient to produce most arrhythmias in the sick sinus syndrome.},
  author       = {Östborn, Per and Wohlfart, Björn and Ohlén, Gunnar},
  issn         = {1095-8541},
  language     = {eng},
  number       = {3},
  pages        = {201--217},
  publisher    = {Academic Press},
  series       = {Journal of Theoretical Biology},
  title        = {Arrhythmia as a result of poor intercellular coupling in the sinus node: A simulation study},
  url          = {http://dx.doi.org/10.1006/jtbi.2001.2339},
  doi          = {10.1006/jtbi.2001.2339},
  volume       = {211},
  year         = {2001},
}