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Nocturnal application of transdermal estradiol patches produces levels of estradiol that mimic those seen at the onset of spontaneous puberty in girls

Ankarberg-Lindgren, Carina; Elfving, Maria LU ; Albertsson Wikland, Kerstin and Norjavaara, Ensio (2001) In Journal of Clinical Endocrinology and Metabolism 86(7). p.3039-3044
Abstract
The objective of pubertal induction in children with hypogonadism is to mimic spontaneous puberty in terms of physical and psychological development. In a clinical observation study, we induced puberty in 15 girls with hyper- or hypogonadotropic hypogonadism using low doses of transdermal estradiol patches attached only during the night and compared the estradiol concentrations obtained with those in healthy girls. Pubertal induction was started between the ages of 12.3 and 18.1 yr. A transdermal matrix patch of 17 beta -estradiol (25 mug/24 h; Evorel, Janssen Pharmaceuticals-Cilag) was cut into pieces corresponding to 3.1, 4.2, or 6.2 mug/24 h initially and attached to the buttock. After 4-14 months, the dose was increased gradually.... (More)
The objective of pubertal induction in children with hypogonadism is to mimic spontaneous puberty in terms of physical and psychological development. In a clinical observation study, we induced puberty in 15 girls with hyper- or hypogonadotropic hypogonadism using low doses of transdermal estradiol patches attached only during the night and compared the estradiol concentrations obtained with those in healthy girls. Pubertal induction was started between the ages of 12.3 and 18.1 yr. A transdermal matrix patch of 17 beta -estradiol (25 mug/24 h; Evorel, Janssen Pharmaceuticals-Cilag) was cut into pieces corresponding to 3.1, 4.2, or 6.2 mug/24 h initially and attached to the buttock. After 4-14 months, the dose was increased gradually. Serum 17 beta -estradiol concentrations were measured every 2 h by RIA (detection limit, 6.0 pmol/L; 1.6 pg/mL). The results show that it is possible to mimic the spontaneous levels as well as the diurnal pattern of serum 17 beta -estradiol in early puberty, by cutting a transdermal 17 beta -estradiol matrix patch and attaching a part of it, corresponding to 0.08-0.12 pg estradiol/kg BW, to the buttock nocturnally. In most of the girls, breast development occurred within 3- 6 months of the start of treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
86
issue
7
pages
3039 - 3044
publisher
The Endocrine Society
external identifiers
  • wos:000169838300023
  • pmid:11443165
  • scopus:0034919022
ISSN
1945-7197
language
English
LU publication?
yes
id
3172d86a-f1dd-4e61-ab4f-5d31b2f93392 (old id 1119086)
date added to LUP
2008-06-23 16:34:26
date last changed
2018-04-08 04:16:45
@article{3172d86a-f1dd-4e61-ab4f-5d31b2f93392,
  abstract     = {The objective of pubertal induction in children with hypogonadism is to mimic spontaneous puberty in terms of physical and psychological development. In a clinical observation study, we induced puberty in 15 girls with hyper- or hypogonadotropic hypogonadism using low doses of transdermal estradiol patches attached only during the night and compared the estradiol concentrations obtained with those in healthy girls. Pubertal induction was started between the ages of 12.3 and 18.1 yr. A transdermal matrix patch of 17 beta -estradiol (25 mug/24 h; Evorel, Janssen Pharmaceuticals-Cilag) was cut into pieces corresponding to 3.1, 4.2, or 6.2 mug/24 h initially and attached to the buttock. After 4-14 months, the dose was increased gradually. Serum 17 beta -estradiol concentrations were measured every 2 h by RIA (detection limit, 6.0 pmol/L; 1.6 pg/mL). The results show that it is possible to mimic the spontaneous levels as well as the diurnal pattern of serum 17 beta -estradiol in early puberty, by cutting a transdermal 17 beta -estradiol matrix patch and attaching a part of it, corresponding to 0.08-0.12 pg estradiol/kg BW, to the buttock nocturnally. In most of the girls, breast development occurred within 3- 6 months of the start of treatment.},
  author       = {Ankarberg-Lindgren, Carina and Elfving, Maria and Albertsson Wikland, Kerstin and Norjavaara, Ensio},
  issn         = {1945-7197},
  language     = {eng},
  number       = {7},
  pages        = {3039--3044},
  publisher    = {The Endocrine Society},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {Nocturnal application of transdermal estradiol patches produces levels of estradiol that mimic those seen at the onset of spontaneous puberty in girls},
  volume       = {86},
  year         = {2001},
}